Literature DB >> 3162348

Efficient computations in multilocus linkage analysis.

G M Lathrop1, J M Lalouel.   

Abstract

This paper describes efficient methods for likelihood calculations and maximum-likelihood estimation in multilocus linkage analysis of reference families and general disease pedigrees, and it documents their performance as implemented in the LINKAGE programs. This information should be of considerable value in determining computing needs for linkage investigations, and in evaluating the merits of alternative algorithms.

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Year:  1988        PMID： 3162348      PMCID： PMC1715153     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  18 in total

1.  A general model for the genetic analysis of pedigree data.

Authors:  R C Elston; J Stewart
Journal:  Hum Hered       Date:  1971       Impact factor: 0.444

2.  Extensions to pedigree analysis. V. Optimal calculation of Mendelian likelihoods.

Authors:  K Lange; M Boehnke
Journal:  Hum Hered       Date:  1983       Impact factor: 0.444

3.  A polymorphic DNA marker genetically linked to Huntington's disease.

Authors:  J F Gusella; N S Wexler; P M Conneally; S L Naylor; M A Anderson; R E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
Journal:  Nature       Date:  1983 Nov 17-23       Impact factor: 49.962

4.  Information gain in joint linkage analysis.

Authors:  E A Thompson
Journal:  IMA J Math Appl Med Biol       Date:  1984

5.  The genetic linkage map of the human X chromosome.

Authors:  D Drayna; R White
Journal:  Science       Date:  1985-11-15       Impact factor: 47.728

6.  An algorithm to improve the computational efficiency of genetic linkage analysis.

Authors:  M S Braverman
Journal:  Comput Biomed Res       Date:  1985-02

7.  Easy calculations of lod scores and genetic risks on small computers.

Authors:  G M Lathrop; J M Lalouel
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

8.  A closely linked genetic marker for cystic fibrosis.

Authors:  R White; S Woodward; M Leppert; P O'Connell; M Hoff; J Herbst; J M Lalouel; M Dean; G Vande Woude
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962

9.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

10.  Localization of cystic fibrosis locus to human chromosome 7cen-q22.

Authors:  B J Wainwright; P J Scambler; J Schmidtke; E A Watson; H Y Law; M Farrall; H J Cooke; H Eiberg; R Williamson
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962
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  40 in total

1.  An optimal algorithm for automatic genotype elimination.

Authors:  J R O'Connell; D E Weeks
Journal:  Am J Hum Genet       Date:  1999-12       Impact factor: 11.025

2.  Aristaless-Like Homeobox protein 1 (ALX1) variant associated with craniofacial structure and frontonasal dysplasia in Burmese cats.

Authors:  Leslie A Lyons; Carolyn A Erdman; Robert A Grahn; Michael J Hamilton; Michael J Carter; Christopher R Helps; Hasan Alhaddad; Barbara Gandolfi
Journal:  Dev Biol       Date:  2015-12-02       Impact factor: 3.582

3.  Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35.

Authors:  K D Mathews; K A Mills; E P Bosch; V V Ionasescu; K R Wiles; K H Buetow; J C Murray
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

4.  Linkage mapping of D21S171 to the distal long arm of human chromosome 21 using a polymorphic (AC)n dinucleotide repeat.

Authors:  M B Petersen; J L Weber; S A Slaugenhaupt; A E Kwitek; M G McInnis; A Chakravarti; S E Antonarakis
Journal:  Hum Genet       Date:  1991-08       Impact factor: 4.132

5.  Maximum-likelihood models for mapping genetic markers showing segregation distortion. 1. Backcross populations.

Authors:  M Lorieux; B Goffinet; X Perrier; D G de León; C Lanaud
Journal:  Theor Appl Genet       Date:  1995-01       Impact factor: 5.699

6.  Pedigree and sib-pair linkage analysis suggest the apolipoprotein B gene is not the major gene influencing plasma apolipoprotein B levels.

Authors:  J Coresh; T H Beaty; P O Kwiterovich; S E Antonarakis
Journal:  Am J Hum Genet       Date:  1992-05       Impact factor: 11.025

7.  Localization of a gene for partial epilepsy to chromosome 10q.

Authors:  R Ottman; N Risch; W A Hauser; T A Pedley; J H Lee; C Barker-Cummings; A Lustenberger; K J Nagle; K S Lee; M L Scheuer
Journal:  Nat Genet       Date:  1995-05       Impact factor: 38.330

8.  The first comprehensive genetic linkage map of a marsupial: the tammar wallaby (Macropus eugenii).

Authors:  Kyall R Zenger; Louise M McKenzie; Desmond W Cooper
Journal:  Genetics       Date:  2002-09       Impact factor: 4.562

9.  X-linked dominant cone-rod degeneration: linkage mapping of a new locus for retinitis pigmentosa (RP 15) to Xp22.13-p22.11.

Authors:  R E McGuire; L S Sullivan; S H Blanton; M W Church; J R Heckenlively; S P Daiger
Journal:  Am J Hum Genet       Date:  1995-07       Impact factor: 11.025

10.  In situ hybridization mapping of the growth hormone receptor (GHR) gene assigns a linkage group (C9, FS, GHR, and S0105) to chromosome 16 in pigs.

Authors:  B P Chowdhary; H Ellegren; M Johansson; L Andersson; I Gustavsson
Journal:  Mamm Genome       Date:  1994-03       Impact factor: 2.957
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