Literature DB >> 3754008

A computer programme to calculate risk in X linked disorders using multiple marker loci.

J F Clayton.   

Abstract

A computer programme package has been written which calculates the genetic risk (recurrence risk) for X linked disorders, incorporating data from multiple probes. The programme can allow new mutation and the incorporation of other predictors of the disease genotype of the subjects in the family.

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Year:  1986        PMID： 3754008      PMCID： PMC1049538          DOI： 10.1136/jmg.23.1.35

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  11 in total

1.  Construction of linkage maps with DNA markers for human chromosomes.

Authors:  R White; M Leppert; D T Bishop; D Barker; J Berkowitz; C Brown; P Callahan; T Holm; L Jerominski
Journal:  Nature       Date:  1985 Jan 10-18       Impact factor: 49.962

2.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

3.  The estimation of recurrence risks in monogenic disorders using flanking marker loci.

Authors:  R M Winter
Journal:  J Med Genet       Date:  1985-02       Impact factor: 6.318

4.  PEDIG--a computer program for calculation of genotype probabilities using phenotype information.

Authors:  I Heuch; F H Li
Journal:  Clin Genet       Date:  1972       Impact factor: 4.438

5.  Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.

Authors:  J M Murray; K E Davies; P S Harper; L Meredith; C R Mueller; R Williamson
Journal:  Nature       Date:  1982-11-04       Impact factor: 49.962

Review 6.  Duchenne muscular dystrophy. Genetic aspects, carrier detection and antenatal diagnosis.

Authors:  A E Emery
Journal:  Br Med Bull       Date:  1980-05       Impact factor: 4.291

7.  Easy calculations of lod scores and genetic risks on small computers.

Authors:  G M Lathrop; J M Lalouel
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

8.  Close genetic linkage between X-linked retinitis pigmentosa and a restriction fragment length polymorphism identified by recombinant DNA probe L1.28.

Authors:  S S Bhattacharya; A F Wright; J F Clayton; W H Price; C I Phillips; C M McKeown; M Jay; A C Bird; P L Pearson; E M Southern
Journal:  Nature       Date:  1984 May 17-23       Impact factor: 49.962

9.  A clinically useful DNA probe closely linked to haemophilia A.

Authors:  K Harper; R M Winter; M E Pembrey; D Hartley; K E Davies; E G Tuddenham
Journal:  Lancet       Date:  1984-07-07       Impact factor: 79.321

10.  Genetic linkage between Becker muscular dystrophy and a polymorphic DNA sequence on the short arm of the X chromosome.

Authors:  H M Kingston; N S Thomas; P L Pearson; M Sarfarazi; P S Harper
Journal:  J Med Genet       Date:  1983-08       Impact factor: 6.318
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  3 in total

1.  A multipoint linkage analysis program for X-linked disorders, with the example of Duchenne muscular dystrophy and seven DNA probes.

Authors:  J Clayton
Journal:  Hum Genet       Date:  1986-05       Impact factor: 4.132

2.  The population genetics of Duchenne: natural and artificial selection in Duchenne muscular dystrophy.

Authors:  J H Edwards
Journal:  J Med Genet       Date:  1986-12       Impact factor: 6.318

3.  A simple method for calculating risks before DNA analysis.

Authors:  M Jeanpierre
Journal:  J Med Genet       Date:  1988-10       Impact factor: 6.318
  3 in total

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