Yili Jin1, Colm McAlinden1,2, Yong Sun3, Daizong Wen1, Yiran Wang1, Jinjin Yu1, Ke Feng1, Benhao Song1, Qinmei Wang1,4, Shihao Chen5,6,7, Jinhai Huang8,9,10. 1. School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. 2. Department of Ophthalmology, Singleton Hospital, Swansea Bay University Health Board, Swansea, UK. 3. Shenzhen Hospital of Integrated Traditional and Western Medicine, Shenzhen, China. 4. Key Laboratory of Vision Science, Ministry of Health P.R. China, Wenzhou, Zhejiang, China. 5. School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. chenle@rocketmail.com. 6. Key Laboratory of Vision Science, Ministry of Health P.R. China, Wenzhou, Zhejiang, China. chenle@rocketmail.com. 7. Eye Hospital of Wenzhou Medical University, 270 West Xueyuan Road, Wenzhou, 325027, Zhejiang, China. chenle@rocketmail.com. 8. School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. vip999vip@163.com. 9. Key Laboratory of Vision Science, Ministry of Health P.R. China, Wenzhou, Zhejiang, China. vip999vip@163.com. 10. Eye Hospital of Wenzhou Medical University, 270 West Xueyuan Road, Wenzhou, 325027, Zhejiang, China. vip999vip@163.com.
Abstract
BACKGROUND: To compare the difference in central corneal thickness (CCT) measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer (Sirius, CSO, Italy) and ultrasound pachymetry (USP). METHODS: A systematic literature search was conducted for relevant studies published on PubMed, Medline, EMBASE, and the Cochrane Library and ClinicalTrials.gov from inception to August 1st, 2019. Primary outcome measures were CCT measurements between Sirius and USP. A random effects model was used to pool CCT measurements. RESULTS: A total of twelve studies involving 862 eyes were included in this meta-analysis. The meta-analysis found CCT measurements between Sirius and USP to be statistically significantly different (P < 0.0001). The mean difference between Sirius and USP was -11.26 μm with a 95% confidence interval (CI) (-16.92 μm, -5.60 μm). The heterogeneity was I2 = 60% (P = 0.004). CONCLUSION: CCT measurements with the Sirius Scheimpflug-Placido topographer were statistically significantly lower than USP. However, it may be argued that the mean difference of 11.26 μm is not a clinically significant difference.
BACKGROUND: To compare the difference in central corneal thickness (CCT) measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer (Sirius, CSO, Italy) and ultrasound pachymetry (USP). METHODS: A systematic literature search was conducted for relevant studies published on PubMed, Medline, EMBASE, and the Cochrane Library and ClinicalTrials.gov from inception to August 1st, 2019. Primary outcome measures were CCT measurements between Sirius and USP. A random effects model was used to pool CCT measurements. RESULTS: A total of twelve studies involving 862 eyes were included in this meta-analysis. The meta-analysis found CCT measurements between Sirius and USP to be statistically significantly different (P < 0.0001). The mean difference between Sirius and USP was -11.26 μm with a 95% confidence interval (CI) (-16.92 μm, -5.60 μm). The heterogeneity was I2 = 60% (P = 0.004). CONCLUSION:CCT measurements with the Sirius Scheimpflug-Placido topographer were statistically significantly lower than USP. However, it may be argued that the mean difference of 11.26 μm is not a clinically significant difference.
Entities:
Keywords:
Central corneal thickness; Meta-analysis; Scheimpflug-Placido topographer; Ultrasound Pachymetry
Authors: Ali Şimşek; Şemsettin Bilak; Mete Güler; Musa Çapkin; Burak Bilgin; Ali Hakim Reyhan Journal: Semin Ophthalmol Date: 2014-11-20 Impact factor: 1.975