Mark V Horton1, Jeniel E Nett1. 1. University of Wisconsin-Madison, Departments of Medicine and Medical Microbiology & Immunology, Wisconsin, United States of America.
Abstract
PURPOSE OF REVIEW: Emergent fungal pathogen C. auris is spreading in hospitals throughout the world and mortality rates for patients with invasive disease approach 60%. This species exhibits a heightened capacity to colonize skin, persist on hospital surfaces, rapidly disseminate in healthcare settings, and resist antifungal therapy. RECENT FINDINGS: Current investigations show that C. auris produces biofilms, surface-adherent communities that resist antifungals and withstand desiccation. These biofilms form when C. auris is growing on skin or in conditions expected in the hospital environment and on implanted medical devices. SUMMARY: Here we will highlight the topic of biofilm formation by C. auris. We illustrate how this process influences resistance to antimicrobials and promotes nosocomial transmission.
PURPOSE OF REVIEW: Emergent fungal pathogen C. auris is spreading in hospitals throughout the world and mortality rates for patients with invasive disease approach 60%. This species exhibits a heightened capacity to colonize skin, persist on hospital surfaces, rapidly disseminate in healthcare settings, and resist antifungal therapy. RECENT FINDINGS: Current investigations show that C. auris produces biofilms, surface-adherent communities that resist antifungals and withstand desiccation. These biofilms form when C. auris is growing on skin or in conditions expected in the hospital environment and on implanted medical devices. SUMMARY: Here we will highlight the topic of biofilm formation by C. auris. We illustrate how this process influences resistance to antimicrobials and promotes nosocomial transmission.
Authors: Fruzsina Nagy; Zoltán Tóth; Lajos Daróczi; Adrien Székely; Andrew M Borman; László Majoros; Renátó Kovács Journal: Med Mycol Date: 2020-04-01 Impact factor: 4.076
Authors: Shawn R Lockhart; Kizee A Etienne; Snigdha Vallabhaneni; Joveria Farooqi; Anuradha Chowdhary; Nelesh P Govender; Arnaldo Lopes Colombo; Belinda Calvo; Christina A Cuomo; Christopher A Desjardins; Elizabeth L Berkow; Mariana Castanheira; Rindidzani E Magobo; Kauser Jabeen; Rana J Asghar; Jacques F Meis; Brendan Jackson; Tom Chiller; Anastasia P Litvintseva Journal: Clin Infect Dis Date: 2016-10-20 Impact factor: 9.079
Authors: Michael A Pfaller; Daniel J Diekema; John D Turnidge; Mariana Castanheira; Ronald N Jones Journal: Open Forum Infect Dis Date: 2019-03-15 Impact factor: 3.835
Authors: Mark V Horton; Chad J Johnson; John F Kernien; Tarika D Patel; Brandon C Lam; J Z Alex Cheong; Jennifer J Meudt; Dhanansayan Shanmuganayagam; Lindsay R Kalan; Jeniel E Nett Journal: mSphere Date: 2020-01-22 Impact factor: 4.389
Authors: Fruzsina Nagy; Zoltán Tóth; Fanni Nyikos; Lajos Forgács; Ágnes Jakab; Andrew M Borman; László Majoros; Renátó Kovács Journal: Med Mycol Date: 2021-10-04 Impact factor: 4.076
Authors: Iara Baldim; Mario H Paziani; Patrícia H Grizante Barião; Marcia R von Zeska Kress; Wanderley P Oliveira Journal: Pharmaceutics Date: 2022-01-13 Impact factor: 6.321