Literature DB >> 20516280

Role of Fks1p and matrix glucan in Candida albicans biofilm resistance to an echinocandin, pyrimidine, and polyene.

Jeniel E Nett1, Kyler Crawford, Karen Marchillo, David R Andes.   

Abstract

Candida infections frequently involve drug-resistant biofilm growth on device surfaces. Glucan synthase gene FKS1 has been linked to triazole resistance in Candida biofilms. We tested the impact of FKS1 modulation on susceptibility to additional antifungal classes. Reduction of FKS1 expression rendered biofilms more susceptible to amphotericin B, anidulafungin, and flucytosine. Increased resistance to anidulafungin and amphotericin B was observed for biofilms overexpressing FKS1. These findings suggest that Candida biofilm glucan sequestration is a multidrug resistance mechanism.

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Year:  2010        PMID： 20516280      PMCID： PMC2916329          DOI： 10.1128/AAC.00227-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

Review 1.  Biofilm formation: a clinically relevant microbiological process.

Authors:  R M Donlan
Journal:  Clin Infect Dis       Date:  2001-09-20       Impact factor: 9.079

2.  To build a biofilm.

Authors:  George A O'Toole
Journal:  J Bacteriol       Date:  2003-05       Impact factor: 3.490

Review 3.  Candida biofilms: antifungal resistance and emerging therapeutic options.

Authors:  Duncan M Kuhn; Mahmoud A Ghannoum
Journal:  Curr Opin Investig Drugs       Date:  2004-02

4.  In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies.

Authors:  Gordon Ramage; Kacy VandeWalle; Stefano P Bachmann; Brian L Wickes; José L López-Ribot
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

5.  Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance.

Authors:  J Chandra; D M Kuhn; P K Mukherjee; L L Hoyer; T McCormick; M A Ghannoum
Journal:  J Bacteriol       Date:  2001-09       Impact factor: 3.490

Review 6.  Candida infections of medical devices.

Authors:  Erna M Kojic; Rabih O Darouiche
Journal:  Clin Microbiol Rev       Date:  2004-04       Impact factor: 26.132

7.  Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery.

Authors:  Terry Roemer; Bo Jiang; John Davison; Troy Ketela; Karynn Veillette; Anouk Breton; Fatou Tandia; Annie Linteau; Susan Sillaots; Catarina Marta; Nick Martel; Steeve Veronneau; Sebastien Lemieux; Sarah Kauffman; Jeff Becker; Reginald Storms; Charles Boone; Howard Bussey
Journal:  Mol Microbiol       Date:  2003-10       Impact factor: 3.501

8.  Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols.

Authors:  Pranab K Mukherjee; Jyotsna Chandra; Duncan M Kuhn; Mahmoud A Ghannoum
Journal:  Infect Immun       Date:  2003-08       Impact factor: 3.441

Review 9.  Candida biofilms and their role in infection.

Authors:  L Julia Douglas
Journal:  Trends Microbiol       Date:  2003-01       Impact factor: 17.079

10.  A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance.

Authors:  Thien-Fah Mah; Betsey Pitts; Brett Pellock; Graham C Walker; Philip S Stewart; George A O'Toole
Journal:  Nature       Date:  2003-11-20       Impact factor: 49.962
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  78 in total

1.  Effects of fluconazole, amphotericin B, and caspofungin on Candida albicans biofilms under conditions of flow and on biofilm dispersion.

Authors:  Priya Uppuluri; Anand Srinivasan; Anand Ramasubramanian; Jose L Lopez-Ribot
Journal:  Antimicrob Agents Chemother       Date:  2011-04-25       Impact factor: 5.191

Review 2.  Candida albicans Biofilms and Human Disease.

Authors:  Clarissa J Nobile; Alexander D Johnson
Journal:  Annu Rev Microbiol       Date:  2015       Impact factor: 15.500

3.  Enhanced Efflux Pump Activity in Old Candida glabrata Cells.

Authors:  Somanon Bhattacharya; Bettina C Fries
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

4.  Topological and mutational analysis of Saccharomyces cerevisiae Fks1.

Authors:  Michael E Johnson; Thomas D Edlind
Journal:  Eukaryot Cell       Date:  2012-05-11

5.  Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo.

Authors:  Megan L Falsetta; Marlise I Klein; Punsiri M Colonne; Kathleen Scott-Anne; Stacy Gregoire; Chia-Hua Pai; Mireya Gonzalez-Begne; Gene Watson; Damian J Krysan; William H Bowen; Hyun Koo
Journal:  Infect Immun       Date:  2014-02-24       Impact factor: 3.441

Review 6.  Mechanisms of Antifungal Drug Resistance.

Authors:  Leah E Cowen; Dominique Sanglard; Susan J Howard; P David Rogers; David S Perlin
Journal:  Cold Spring Harb Perspect Med       Date:  2014-11-10       Impact factor: 6.915

7.  Candida albicans Biofilm Development and Its Genetic Control.

Authors:  Jigar V Desai; Aaron P Mitchell
Journal:  Microbiol Spectr       Date:  2015-06

8.  The Ca-loop in thymidylate kinase is critical for growth and contributes to pyrimidine drug sensitivity of Candida albicans.

Authors:  Chang-Yu Huang; Yee-Chun Chen; Betty A Wu-Hsieh; Jim-Min Fang; Zee-Fen Chang
Journal:  J Biol Chem       Date:  2019-05-31       Impact factor: 5.157

Review 9.  Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota.

Authors:  Sarah Höfs; Selene Mogavero; Bernhard Hube
Journal:  J Microbiol       Date:  2016-02-27       Impact factor: 3.422

Review 10.  Fungal biofilms, drug resistance, and recurrent infection.

Authors:  Jigar V Desai; Aaron P Mitchell; David R Andes
Journal:  Cold Spring Harb Perspect Med       Date:  2014-10-01       Impact factor: 6.915
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