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Literature DB >> 31127836

Farnesol increases the activity of echinocandins against Candida auris biofilms.

Fruzsina Nagy¹, Zoltán Tóth¹, Lajos Daróczi², Adrien Székely³, Andrew M Borman³, László Majoros¹, Renátó Kovács^1,4.

Abstract

Candida auris biofilms exhibit decreased susceptibility to echinocandins, which is associated with poorer clinical outcomes. Farnesol is a quorum-sensing molecule enhancing the activity of antifungals; therefore, we evaluated the in vitro effect of farnesol with anidulafungin, caspofungin, or micafungin against biofilms using fractional inhibitory concentration indexes (FICI), Bliss independence model, LIVE/DEAD-assay and scanning electron microscopy. Based on mathematical models, farnesol caused synergism in eleven out of twelve cases (FICIs range 0.133-0.507; Bliss synergy volume range 70.39-204.6 μM2%). This was confirmed by microscope images of combination-exposed biofilms. Our study showed the prominent effect of farnesol with echinocandins against C. auris biofilms.

Entities: Chemical Disease Species

Keywords: Candida auris; biofilm; farnesol; lock therapy; synergy

Year: 2020 PMID： 31127836 DOI： 10.1093/mmy/myz057

Source DB: PubMed Journal: Med Mycol ISSN： 1369-3786 Impact factor: 4.076

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Cited

12 in total

Review 1. Emerging and future strategies in the management of recalcitrant Candida auris.

Authors: Nihal Bandara; Lakshman Samaranayake
Journal: Med Mycol Date: 2022-03-17 Impact factor: 4.076

Review 2. Candida auris, a singular emergent pathogenic yeast: its resistance and new therapeutic alternatives.

Authors: Liliana Fernandes; Rita Ribeiro; Mariana Henriques; Maria Elisa Rodrigues
Journal: Eur J Clin Microbiol Infect Dis Date: 2022-10-06 Impact factor: 5.103

3. In vitro and in vivo interaction of caspofungin with isavuconazole against Candida auris planktonic cells and biofilms.

Authors: Fruzsina Nagy; Zoltán Tóth; Fanni Nyikos; Lajos Forgács; Ágnes Jakab; Andrew M Borman; László Majoros; Renátó Kovács
Journal: Med Mycol Date: 2021-10-04 Impact factor: 4.076

Review 4. Farnesol and Tyrosol: Secondary Metabolites with a Crucial quorum-sensing Role in Candida Biofilm Development.

Authors: Célia F Rodrigues; Lucia Černáková
Journal: Genes (Basel) Date: 2020-04-18 Impact factor: 4.096

5. Transcriptional Profiling of the Candida auris Response to Exogenous Farnesol Exposure.

Authors: Ágnes Jakab; Noémi Balla; Ágota Ragyák; Fruzsina Nagy; Fruzsina Kovács; Zsófi Sajtos; Zoltán Tóth; Andrew M Borman; István Pócsi; Edina Baranyai; László Majoros; Renátó Kovács
Journal: mSphere Date: 2021-10-13 Impact factor: 4.389

Review 6. Echinocandins - structure, mechanism of action and use in antifungal therapy.

Authors: Mateusz Szymański; Sandra Chmielewska; Urszula Czyżewska; Marta Malinowska; Adam Tylicki
Journal: J Enzyme Inhib Med Chem Date: 2022-12 Impact factor: 5.051

7. Evaluation of the Antimicrobial and Antivirulent Potential of Essential Oils Isolated from Juniperus oxycedrus L. ssp. macrocarpa Aerial Parts.

Authors: Gabriella Spengler; Márió Gajdács; Matthew Gavino Donadu; Marianna Usai; Mauro Marchetti; Marco Ferrari; Vittorio Mazzarello; Stefania Zanetti; Fruzsina Nagy; Renátó Kovács
Journal: Microorganisms Date: 2022-03-31