Literature DB >> 31463844

Stable Isotope-Resolved Metabolomics by NMR.

Penghui Lin1, Andrew N Lane2,3, Teresa W-M Fan1,4.   

Abstract

Stable isotopes enable the tracing of atoms from precursors to products via metabolic transformations in situ and in crude extracts. NMR has some unique capabilities that are especially suited for metabolic analysis, including atom position-resolved isotope analysis and isotope editing. In this chapter we describe NMR-based analysis of positional isotopomer distribution using metabolic tracers.

Entities:  

Keywords:  Isotopomers; Quantification; Spectral editing; Stable isotope-resolved metabolomics

Mesh：

Year:  2019        PMID： 31463844      PMCID： PMC7256830          DOI： 10.1007/978-1-4939-9690-2_9

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  15 in total

1.  Methods for the measurement of (1)J(NCalpha) and (2)J(NCalpha) from a simplified 2D (13)C(alpha)-coupled (15)N SE-HSQC spectrum.

Authors:  S Heikkinen; P Permi; I Kilpeläinen
Journal:  J Magn Reson       Date:  2001-01       Impact factor: 2.229

2.  Isotopomer-based metabolomic analysis by NMR and mass spectrometry.

Authors:  Andrew N Lane; Teresa W-M Fan; Richard M Higashi
Journal:  Methods Cell Biol       Date:  2008       Impact factor: 1.441

Review 3.  Heteronuclear filters in two-dimensional [1H,1H]-NMR spectroscopy: combined use with isotope labelling for studies of macromolecular conformation and intermolecular interactions.

Authors:  G Otting; K Wüthrich
Journal:  Q Rev Biophys       Date:  1990-02       Impact factor: 5.318

4.  NMR-based stable isotope resolved metabolomics in systems biochemistry.

Authors:  Teresa W-M Fan; Andrew N Lane
Journal:  J Biomol NMR       Date:  2011-02-26       Impact factor: 2.835

5.  Chemoselective detection and discrimination of carbonyl-containing compounds in metabolite mixtures by 1H-detected 15N nuclear magnetic resonance.

Authors:  Andrew N Lane; Sengodagounder Arumugam; Pawel K Lorkiewicz; Richard M Higashi; Sébastien Laulhé; Michael H Nantz; Hunter N B Moseley; Teresa W-M Fan
Journal:  Magn Reson Chem       Date:  2015-01-23       Impact factor: 2.447

6.  1H, 13C and 15N chemical shift referencing in biomolecular NMR.

Authors:  D S Wishart; C G Bigam; J Yao; F Abildgaard; H J Dyson; E Oldfield; J L Markley; B D Sykes
Journal:  J Biomol NMR       Date:  1995-09       Impact factor: 2.835

Review 7.  The use of 2H, 13C, 15N multidimensional NMR to study the structure and dynamics of proteins.

Authors:  K H Gardner; L E Kay
Journal:  Annu Rev Biophys Biomol Struct       Date:  1998

8.  15N-cholamine--a smart isotope tag for combining NMR- and MS-based metabolite profiling.

Authors:  Fariba Tayyari; G A Nagana Gowda; Haiwei Gu; Daniel Raftery
Journal:  Anal Chem       Date:  2013-08-26       Impact factor: 6.986

Review 9.  NMR structure determination of proteins and protein complexes larger than 20 kDa.

Authors:  G M Clore; A M Gronenborn
Journal:  Curr Opin Chem Biol       Date:  1998-10       Impact factor: 8.822

10.  Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small-cell lung cancer study.

Authors:  Teresa W-M Fan; Marc O Warmoes; Qiushi Sun; Huan Song; Jadwiga Turchan-Cholewo; Jeremiah T Martin; Angela Mahan; Richard M Higashi; Andrew N Lane
Journal:  Cold Spring Harb Mol Case Stud       Date:  2016-07
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  4 in total

Review 1.  NMR-based isotope editing, chemoselection and isotopomer distribution analysis in stable isotope resolved metabolomics.

Authors:  Penghui Lin; Teresa W-M Fan; Andrew N Lane
Journal:  Methods       Date:  2022-07-28       Impact factor: 4.647

2.  Evaluation of Fumaric Acid and Maleic Acid as Internal Standards for NMR Analysis of Protein Precipitated Plasma, Serum, and Whole Blood.

Authors:  G A Nagana Gowda; Natalie N Hong; Daniel Raftery
Journal:  Anal Chem       Date:  2021-02-04       Impact factor: 6.986

Review 3.  Quantitative flux analysis in mammals.

Authors:  Caroline R Bartman; Tara TeSlaa; Joshua D Rabinowitz
Journal:  Nat Metab       Date:  2021-07-01

4.  In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium.

Authors:  Kyle L Fulghum; Timothy N Audam; Pawel K Lorkiewicz; Yuting Zheng; Michael Merchant; Timothy D Cummins; William L Dean; Teresa A Cassel; Teresa W M Fan; Bradford G Hill
Journal:  J Mol Cell Cardiol       Date:  2021-09-03       Impact factor: 5.000
  4 in total

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