Martin Lyngby Lassen1, Jacek Kwiecinski1,2, Damini Dey1, Sebastien Cadet1, Guido Germano1, Daniel S Berman1, Philip D Adamson2, Alastair J Moss2, Marc R Dweck2, David E Newby2, Piotr J Slomka3. 1. Artificial Intelligence in Medicine Program, Cedars-Sinai Medical Center, 8700 Beverly Blvd Ste A047N, California, Los Angeles, 90048, USA. 2. British Heart Foundation Centre for Cardiovascular Science, Clinical Research Imaging Centre, Edinburgh Heart Centre, University of Edinburgh, Edinburgh, UK. 3. Artificial Intelligence in Medicine Program, Cedars-Sinai Medical Center, 8700 Beverly Blvd Ste A047N, California, Los Angeles, 90048, USA. piotr.slomka@cshs.org.
Abstract
PURPOSE: To improve the test-retest reproducibility of coronary plaque 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) uptake measurements. METHODS: We recruited 20 patients with coronary artery disease who underwent repeated hybrid PET/CT angiography (CTA) imaging within 3 weeks. All patients had 30-min PET acquisition and CTA during a single imaging session. Five PET image-sets with progressive motion correction were reconstructed: (i) a static dataset (no-MC), (ii) end-diastolic PET (standard), (iii) cardiac motion corrected (MC), (iv) combined cardiac and gross patient motion corrected (2 × MC) and, (v) cardiorespiratory and gross patient motion corrected (3 × MC). In addition to motion correction, all datasets were corrected for variations in the background activities which are introduced by variations in the injection-to-scan delays (background blood pool clearance correction, BC). Test-retest reproducibility of PET target-to-background ratio (TBR) was assessed by Bland-Altman analysis and coefficient of reproducibility. RESULTS: A total of 47 unique coronary lesions were identified on CTA. Motion correction in combination with BC improved the PET TBR test-retest reproducibility for all lesions (coefficient of reproducibility: standard = 0.437, no-MC = 0.345 (27% improvement), standard + BC = 0.365 (20% improvement), no-MC + BC = 0.341 (27% improvement), MC + BC = 0.288 (52% improvement), 2 × MC + BC = 0.278 (57% improvement) and 3 × C + BC = 0.254 (72% improvement), all p < 0.001). Importantly, in a sub-analysis of 18F-NaF-avid lesions with gross patient motion > 10 mm following corrections, reproducibility was improved by 133% (coefficient of reproducibility: standard = 0.745, 3 × MC = 0.320). CONCLUSION: Joint corrections for cardiac, respiratory, and gross patient motion in combination with background blood pool corrections markedly improve test-retest reproducibility of coronary 18F-NaF PET.
PURPOSE: To improve the test-retest reproducibility of coronary plaque 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) uptake measurements. METHODS: We recruited 20 patients with coronary artery disease who underwent repeated hybrid PET/CT angiography (CTA) imaging within 3 weeks. All patients had 30-min PET acquisition and CTA during a single imaging session. Five PET image-sets with progressive motion correction were reconstructed: (i) a static dataset (no-MC), (ii) end-diastolic PET (standard), (iii) cardiac motion corrected (MC), (iv) combined cardiac and gross patient motion corrected (2 × MC) and, (v) cardiorespiratory and gross patient motion corrected (3 × MC). In addition to motion correction, all datasets were corrected for variations in the background activities which are introduced by variations in the injection-to-scan delays (background blood pool clearance correction, BC). Test-retest reproducibility of PET target-to-background ratio (TBR) was assessed by Bland-Altman analysis and coefficient of reproducibility. RESULTS: A total of 47 unique coronary lesions were identified on CTA. Motion correction in combination with BC improved the PET TBR test-retest reproducibility for all lesions (coefficient of reproducibility: standard = 0.437, no-MC = 0.345 (27% improvement), standard + BC = 0.365 (20% improvement), no-MC + BC = 0.341 (27% improvement), MC + BC = 0.288 (52% improvement), 2 × MC + BC = 0.278 (57% improvement) and 3 × C + BC = 0.254 (72% improvement), all p < 0.001). Importantly, in a sub-analysis of 18F-NaF-avid lesions with gross patient motion > 10 mm following corrections, reproducibility was improved by 133% (coefficient of reproducibility: standard = 0.745, 3 × MC = 0.320). CONCLUSION: Joint corrections for cardiac, respiratory, and gross patient motion in combination with background blood pool corrections markedly improve test-retest reproducibility of coronary 18F-NaF PET.
Authors: Jacek Kwiecinski; Daniel S Berman; Sang-Eun Lee; Damini Dey; Sebastien Cadet; Martin L Lassen; Guido Germano; Maurits A Jansen; Marc R Dweck; David E Newby; Hyuk-Jae Chang; Mijin Yun; Piotr J Slomka Journal: J Nucl Med Date: 2018-09-13 Impact factor: 10.057
Authors: Marc R Dweck; Marcus W L Chow; Nikhil V Joshi; Michelle C Williams; Charlotte Jones; Alison M Fletcher; Hamish Richardson; Audrey White; Graham McKillop; Edwin J R van Beek; Nicholas A Boon; James H F Rudd; David E Newby Journal: J Am Coll Cardiol Date: 2012-04-24 Impact factor: 24.094
Authors: Mathieu Rubeaux; Nikhil V Joshi; Marc R Dweck; Alison Fletcher; Manish Motwani; Louise E Thomson; Guido Germano; Damini Dey; Debiao Li; Daniel S Berman; David E Newby; Piotr J Slomka Journal: J Nucl Med Date: 2015-10-15 Impact factor: 10.057
Authors: Tania A Pawade; Timothy R G Cartlidge; William S A Jenkins; Philip D Adamson; Phillip Robson; Christophe Lucatelli; Edwin J R Van Beek; Bernard Prendergast; Alan R Denison; Laura Forsyth; James H F Rudd; Zahi A Fayad; Alison Fletcher; Sharon Tuck; David E Newby; Marc R Dweck Journal: Circ Cardiovasc Imaging Date: 2016-10 Impact factor: 7.792
Authors: Jason M Tarkin; Francis R Joshi; Nicholas R Evans; Mohammed M Chowdhury; Nichola L Figg; Aarti V Shah; Lakshi T Starks; Abel Martin-Garrido; Roido Manavaki; Emma Yu; Rhoda E Kuc; Luigi Grassi; Roman Kreuzhuber; Myrto A Kostadima; Mattia Frontini; Peter J Kirkpatrick; Patrick A Coughlin; Deepa Gopalan; Tim D Fryer; John R Buscombe; Ashley M Groves; Willem H Ouwehand; Martin R Bennett; Elizabeth A Warburton; Anthony P Davenport; James H F Rudd Journal: J Am Coll Cardiol Date: 2017-04-11 Impact factor: 24.094
Authors: Jan Bucerius; Venkatesh Mani; Colin Moncrieff; Josef Machac; Valentin Fuster; Michael E Farkouh; Ahmed Tawakol; James H F Rudd; Zahi A Fayad Journal: Eur J Nucl Med Mol Imaging Date: 2013-11-23 Impact factor: 9.236
Authors: Brett W Sperry; Timothy M Bateman; Esma A Akin; Paco E Bravo; Wengen Chen; Vasken Dilsizian; Fabien Hyafil; Yiu Ming Khor; Robert J H Miller; Riemer H J A Slart; Piotr Slomka; Hein Verberne; Edward J Miller; Chi Liu Journal: J Nucl Cardiol Date: 2022-07-21 Impact factor: 3.872
Authors: Jacek Kwiecinski; Evangelos Tzolos; Alexander J Fletcher; Jennifer Nash; Mohammed N Meah; Sebastien Cadet; Philip D Adamson; Kajetan Grodecki; Nikhil Joshi; Michelle C Williams; Edwin J R van Beek; Chi Lai; Adriana A S Tavares; Mark G MacAskill; Damini Dey; Andrew H Baker; Jonathon Leipsic; Daniel S Berman; Stephanie L Sellers; David E Newby; Marc R Dweck; Piotr J Slomka Journal: JACC Cardiovasc Imaging Date: 2022-02-16
Authors: Jacek Kwiecinski; Evangelos Tzolos; Philip D Adamson; Sebastien Cadet; Alastair J Moss; Nikhil Joshi; Michelle C Williams; Edwin J R van Beek; Damini Dey; Daniel S Berman; David E Newby; Piotr J Slomka; Marc R Dweck Journal: J Am Coll Cardiol Date: 2020-06-23 Impact factor: 24.094
Authors: Evangelos Tzolos; Martin Lyngby Lassen; Tinsu Pan; Jacek Kwiecinski; Sebastien Cadet; Damini Dey; Marc R Dweck; David E Newby; Daniel Berman; Piotr Slomka Journal: J Nucl Cardiol Date: 2020-07-02 Impact factor: 5.952
Authors: Piotr J Slomka; Jonathan B Moody; Robert J H Miller; Jennifer M Renaud; Edward P Ficaro; Ernest V Garcia Journal: J Nucl Cardiol Date: 2020-10-16 Impact factor: 5.952
Authors: Jacek Kwiecinski; Evangelos Tzolos; Mohammed N Meah; Sebastien Cadet; Philip D Adamson; Kajetan Grodecki; Nikhil V Joshi; Alastair J Moss; Michelle C Williams; Edwin J R van Beek; Daniel S Berman; David E Newby; Damini Dey; Marc R Dweck; Piotr J Slomka Journal: J Nucl Med Date: 2021-04-23 Impact factor: 11.082
Authors: Alexander J Fletcher; Yong Y Tew; Evangelos Tzolos; Shruti S Joshi; Jakub Kaczynski; Jennifer Nash; Samuel Debono; Maria Lembo; Jacek Kwiecinski; Rong Bing; Maaz B J Syed; Mhairi K Doris; Edwin J R van Beek; Alistair J Moss; William S Jenkins; Niki L Walker; Nikhil V Joshi; Tania A Pawade; Philip D Adamson; William N Whiteley; Joanna M Wardlaw; Piotr J Slomka; Michelle C Williams; David E Newby; Marc R Dweck Journal: JACC Cardiovasc Imaging Date: 2022-02-16
Authors: Evangelos Tzolos; Jacek Kwiecinski; Martin Lyngby Lassen; Sebastien Cadet; Philip D Adamson; Alastair J Moss; Nikhil Joshi; Michelle C Williams; Edwin J R van Beek; Damini Dey; Daniel S Berman; Marc R Dweck; David E Newby; Piotr J Slomka Journal: J Nucl Cardiol Date: 2020-06-11 Impact factor: 5.952