Evangelos Tzolos1,2, Jacek Kwiecinski1,3, Martin Lyngby Lassen1, Sebastien Cadet1, Philip D Adamson2,4, Alastair J Moss2,5, Nikhil Joshi2,5, Michelle C Williams2,6, Edwin J R van Beek2,6, Damini Dey1, Daniel S Berman1, Marc R Dweck2, David E Newby2,5, Piotr J Slomka7. 1. Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Artificial Intelligence in Medicine Program, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Ste A047N, Los Angeles, CA, 90048, USA. 2. BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK. 3. Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland. 4. Christchurch Heart Institute, University of Otago, Christchurch, New Zealand. 5. BHF Cardiovascular Research Centre, University of Leicester, Leicester, UK. 6. Edinburgh Imaging, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK. 7. Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Artificial Intelligence in Medicine Program, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Ste A047N, Los Angeles, CA, 90048, USA. piotr.slomka@cshs.org.
Abstract
BACKGROUND: We aimed to establish the observer repeatability and interscan reproducibility of coronary 18F-sodium-fluoride positron emission tomography (PET) uptake using a novel semi-automated approach, coronary microcalcification activity (CMA). METHODS: Patients with multivessel coronary artery disease underwent repeated hybrid PET and computed tomography angiography (CTA) imaging (PET/CTA). CMA was defined as the integrated standardized uptake values (SUV) in the entire coronary tree exceeding 2 standard deviations above the background SUV. Coefficients of repeatability between the same observer (intraobserver repeatability), between 2 observers (interobserver repeatability) and coefficient of reproducibility between 2 scans (interscan reproducibility), were determined at vessel and patient level. RESULTS: In 19 patients, CMA was assessed twice in 43 coronary vessels on two PET/CT scans performed 12 ± 5 days apart. There was excellent intraclass correlation for intraobserver and interobserver repeatability as well as interscan reproducibility (all ≥ 0.991). There was 100% intraobserver, interobserver and interscan agreement for the presence (CMA > 0) or absence (CMA = 0) of coronary18F-NaF uptake. Mean CMA was 3.12 ± 0.62 with coefficients of repeatability of ≤ 10% for all measures: intraobserver 0.24 and 0.22, interobserver 0.30 and 0.29 and interscan 0.33 and 0.32 at a per-vessel and per-patient level, respectively. CONCLUSIONS: CMA is a repeatable and reproducible global measure of coronary atherosclerotic activity.
BACKGROUND: We aimed to establish the observer repeatability and interscan reproducibility of coronary 18F-sodium-fluoride positron emission tomography (PET) uptake using a novel semi-automated approach, coronary microcalcification activity (CMA). METHODS: Patients with multivessel coronary artery disease underwent repeated hybrid PET and computed tomography angiography (CTA) imaging (PET/CTA). CMA was defined as the integrated standardized uptake values (SUV) in the entire coronary tree exceeding 2 standard deviations above the background SUV. Coefficients of repeatability between the same observer (intraobserver repeatability), between 2 observers (interobserver repeatability) and coefficient of reproducibility between 2 scans (interscan reproducibility), were determined at vessel and patient level. RESULTS: In 19 patients, CMA was assessed twice in 43 coronary vessels on two PET/CT scans performed 12 ± 5 days apart. There was excellent intraclass correlation for intraobserver and interobserver repeatability as well as interscan reproducibility (all ≥ 0.991). There was 100% intraobserver, interobserver and interscan agreement for the presence (CMA > 0) or absence (CMA = 0) of coronary18F-NaF uptake. Mean CMA was 3.12 ± 0.62 with coefficients of repeatability of ≤ 10% for all measures: intraobserver 0.24 and 0.22, interobserver 0.30 and 0.29 and interscan 0.33 and 0.32 at a per-vessel and per-patient level, respectively. CONCLUSIONS: CMA is a repeatable and reproducible global measure of coronary atherosclerotic activity.
Authors: Philip Greenland; Robert O Bonow; Bruce H Brundage; Matthew J Budoff; Mark J Eisenberg; Scott M Grundy; Michael S Lauer; Wendy S Post; Paolo Raggi; Rita F Redberg; George P Rodgers; Leslee J Shaw; Allen J Taylor; William S Weintraub Journal: J Am Coll Cardiol Date: 2007-01-23 Impact factor: 24.094
Authors: Philip Greenland; Michael J Blaha; Matthew J Budoff; Raimund Erbel; Karol E Watson Journal: J Am Coll Cardiol Date: 2018-07-24 Impact factor: 24.094
Authors: Jacek Kwiecinski; Damini Dey; Sebastien Cadet; Sang-Eun Lee; Balaji Tamarappoo; Yuka Otaki; Phi T Huynh; John D Friedman; Mark R Dweck; David E Newby; Mijin Yun; Hyuk-Jae Chang; Piotr J Slomka; Daniel S Berman Journal: Eur Heart J Cardiovasc Imaging Date: 2020-01-01 Impact factor: 6.875
Authors: Mathieu Rubeaux; Nikhil V Joshi; Marc R Dweck; Alison Fletcher; Manish Motwani; Louise E Thomson; Guido Germano; Damini Dey; Debiao Li; Daniel S Berman; David E Newby; Piotr J Slomka Journal: J Nucl Med Date: 2015-10-15 Impact factor: 10.057
Authors: Matthew J Budoff; Rebekah Young; Gregory Burke; J Jeffrey Carr; Robert C Detrano; Aaron R Folsom; Richard Kronmal; Joao A C Lima; Kiang J Liu; Robyn L McClelland; Erin Michos; Wendy S Post; Steven Shea; Karol E Watson; Nathan D Wong Journal: Eur Heart J Date: 2018-07-01 Impact factor: 35.855
Authors: Jacek Kwiecinski; Evangelos Tzolos; Alexander J Fletcher; Jennifer Nash; Mohammed N Meah; Sebastien Cadet; Philip D Adamson; Kajetan Grodecki; Nikhil Joshi; Michelle C Williams; Edwin J R van Beek; Chi Lai; Adriana A S Tavares; Mark G MacAskill; Damini Dey; Andrew H Baker; Jonathon Leipsic; Daniel S Berman; Stephanie L Sellers; David E Newby; Marc R Dweck; Piotr J Slomka Journal: JACC Cardiovasc Imaging Date: 2022-02-16
Authors: Evangelos Tzolos; Martin Lyngby Lassen; Tinsu Pan; Jacek Kwiecinski; Sebastien Cadet; Damini Dey; Marc R Dweck; David E Newby; Daniel Berman; Piotr Slomka Journal: J Nucl Cardiol Date: 2020-07-02 Impact factor: 5.952
Authors: Jacek Kwiecinski; Evangelos Tzolos; Mohammed N Meah; Sebastien Cadet; Philip D Adamson; Kajetan Grodecki; Nikhil V Joshi; Alastair J Moss; Michelle C Williams; Edwin J R van Beek; Daniel S Berman; David E Newby; Damini Dey; Marc R Dweck; Piotr J Slomka Journal: J Nucl Med Date: 2021-04-23 Impact factor: 11.082
Authors: Alexander J Fletcher; Yong Y Tew; Evangelos Tzolos; Shruti S Joshi; Jakub Kaczynski; Jennifer Nash; Samuel Debono; Maria Lembo; Jacek Kwiecinski; Rong Bing; Maaz B J Syed; Mhairi K Doris; Edwin J R van Beek; Alistair J Moss; William S Jenkins; Niki L Walker; Nikhil V Joshi; Tania A Pawade; Philip D Adamson; William N Whiteley; Joanna M Wardlaw; Piotr J Slomka; Michelle C Williams; David E Newby; Marc R Dweck Journal: JACC Cardiovasc Imaging Date: 2022-02-16