PURPOSE: To characterize the relationship between angle configuration measured by anterior segment optical coherence tomography (AS-OCT) and intraocular pressure (IOP). DESIGN: Cross-sectional study. PARTICIPANTS: Subjects aged 50 years or older were identified from the Chinese American Eye Study (CHES), a population-based epidemiological study in Los Angeles, CA. METHODS: Each subject underwent a complete ocular exam including Goldmann applanation tonometry, gonioscopy, and AS-OCT imaging. Four AS-OCT images were analyzed per eye and parameters describing angle configuration were measured, including angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), trabecular iris angle (TIA), and scleral spur angle (SSA). The relationship between AS-OCT measurements and IOP was assessed using locally-weighted scatterplot smoothing (LOWESS) regression and change-point analyses. MAIN OUTCOME MEASURES: Correlation between AS-OCT measurements and IOP. RESULTS: 702 eyes (382 closed angle and 320 open angle) from 555 subjects were analyzed. Mean IOP for angle closure eyes was 16.3 ± 3.9 mmHg and open angle eyes was 15.3 ± 2.7 mmHg. Mean IOP increased as AS-OCT measurements decreased for all parameters except TIA750. Once measurement values dropped below parameter-specific threshold values, AS-OCT measurements and IOP were significantly correlated (p < 0.05) for AOD500 (r = -0.416), AOD750 (r = -0.213), ARA500 (r = -0.669), ARA750 (r = -0.680), TISA500 (r = -0.655), TISA750 (r = -0.641), SSA500 (r = -0.538), and SSA750 (r = -0.208). There was no correlation between AS-OCT measurements and IOP in open angle eyes (p > 0.40). CONCLUSIONS: There is an anatomic threshold for angle configuration below which IOP is strongly related to the degree of angle closure. This finding suggests reconsideration of current definitions of angle closure and may be relevant for developing new OCT-based methods to identify patients at higher risk for elevated IOP and glaucoma.
PURPOSE: To characterize the relationship between angle configuration measured by anterior segment optical coherence tomography (AS-OCT) and intraocular pressure (IOP). DESIGN: Cross-sectional study. PARTICIPANTS: Subjects aged 50 years or older were identified from the Chinese American Eye Study (CHES), a population-based epidemiological study in Los Angeles, CA. METHODS: Each subject underwent a complete ocular exam including Goldmann applanation tonometry, gonioscopy, and AS-OCT imaging. Four AS-OCT images were analyzed per eye and parameters describing angle configuration were measured, including angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), trabecular iris angle (TIA), and scleral spur angle (SSA). The relationship between AS-OCT measurements and IOP was assessed using locally-weighted scatterplot smoothing (LOWESS) regression and change-point analyses. MAIN OUTCOME MEASURES: Correlation between AS-OCT measurements and IOP. RESULTS: 702 eyes (382 closed angle and 320 open angle) from 555 subjects were analyzed. Mean IOP for angle closure eyes was 16.3 ± 3.9 mmHg and open angle eyes was 15.3 ± 2.7 mmHg. Mean IOP increased as AS-OCT measurements decreased for all parameters except TIA750. Once measurement values dropped below parameter-specific threshold values, AS-OCT measurements and IOP were significantly correlated (p < 0.05) for AOD500 (r = -0.416), AOD750 (r = -0.213), ARA500 (r = -0.669), ARA750 (r = -0.680), TISA500 (r = -0.655), TISA750 (r = -0.641), SSA500 (r = -0.538), and SSA750 (r = -0.208). There was no correlation between AS-OCT measurements and IOP in open angle eyes (p > 0.40). CONCLUSIONS: There is an anatomic threshold for angle configuration below which IOP is strongly related to the degree of angle closure. This finding suggests reconsideration of current definitions of angle closure and may be relevant for developing new OCT-based methods to identify patients at higher risk for elevated IOP and glaucoma.
Authors: Mingguang He; Paul J Foster; Jian Ge; Wenyong Huang; Yingfeng Zheng; David S Friedman; Pak Sang Lee; Peng T Khaw Journal: Invest Ophthalmol Vis Sci Date: 2006-07 Impact factor: 4.799
Authors: Christopher Kai-shun Leung; Carol Yim Lui Cheung; Haitao Li; Syril Dorairaj; Cedric Ka Fai Yiu; Amy Lee Wong; Jeffrey Liebmann; Robert Ritch; Robert Weinreb; Dennis Shun Chiu Lam Journal: Invest Ophthalmol Vis Sci Date: 2007-09 Impact factor: 4.799
Authors: Mingguang He; David S Friedman; Jian Ge; Wenyong Huang; Chenjin Jin; Pak Sang Lee; Peng T Khaw; Paul J Foster Journal: Ophthalmology Date: 2006-11-21 Impact factor: 12.079
Authors: Paul J Foster; David Machin; Tien-Yin Wong; Tze-Pin Ng; Jim F Kirwan; Gordon J Johnson; Peng T Khaw; Steve K L Seah Journal: Invest Ophthalmol Vis Sci Date: 2003-09 Impact factor: 4.799
Authors: Benjamin Y Xu; Anmol A Pardeshi; Jing Shan; Charles DeBoer; Sasan Moghimi; Grace Richter; Roberta McKean-Cowdin; Rohit Varma Journal: Ophthalmol Glaucoma Date: 2019-12-27
Authors: Benjamin Y Xu; Michael Chiang; Shreyasi Chaudhary; Shraddha Kulkarni; Anmol A Pardeshi; Rohit Varma Journal: Am J Ophthalmol Date: 2019-08-22 Impact factor: 5.258
Authors: Alice Shen; Michael Chiang; Anmol A Pardeshi; Roberta McKean-Cowdin; Rohit Varma; Benjamin Y Xu Journal: Br J Ophthalmol Date: 2021-10-06 Impact factor: 4.638
Authors: Benjamin Y Xu; David S Friedman; Paul J Foster; Yu Jiang; Natalia Porporato; Anmol A Pardeshi; Yuzhen Jiang; Beatriz Munoz; Tin Aung; Mingguang He Journal: Ophthalmology Date: 2021-10-08 Impact factor: 12.079
Authors: Benjamin Y Xu; Jacob Lifton; Bruce Burkemper; Xuejuan Jiang; Anmol A Pardeshi; Sasan Moghimi; Grace M Richter; Roberta McKean-Cowdin; Rohit Varma Journal: Am J Ophthalmol Date: 2020-07-28 Impact factor: 5.258
Authors: Benjamin Y Xu; Siqi Liang; Anmol A Pardeshi; Jacob Lifton; Sasan Moghimi; Juan Pablo Lewinger; Rohit Varma Journal: Ophthalmol Glaucoma Date: 2020-09-14