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Literature DB >> 3038534

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

G Matlashewski, J Schneider, L Banks, N Jones, A Murray, L Crawford.

Abstract

The close association of human papillomavirus type 16 DNA with a majority of cervical carcinomas implies some role for the virus in this type of cancer. To define the transforming properties of HPV-16 DNA in vitro we have now performed transfection experiments on baby rat kidney cells using HPV-16 DNA in conjunction with an activated ras gene. We have demonstrated that a 6.6-kb DNA fragment, containing the early genes of HPV-16 under the control of Moloney murine leukaemia virus long terminal repeats (MoMuLV-LTRs), cooperates with EJ-ras in transforming these cells. Both DNAs are required and neither alone is effective. The cooperating activity appears to reside in a protein or proteins derived from the E6/E7 region of the HPV-16 genome.

Entities: Chemical

Mesh：

Substances：
DNA, Viral

Year: 1987 PMID： 3038534 PMCID： PMC553550 DOI： 10.1002/j.1460-2075.1987.tb02426.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

28 in total

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Journal: Nature Date: 1983 Aug 18-24 Impact factor: 49.962

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Journal: Proc Natl Acad Sci U S A Date: 1979-03 Impact factor: 11.205

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Journal: Proc Natl Acad Sci U S A Date: 1983-01 Impact factor: 11.205

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Journal: Proc Natl Acad Sci U S A Date: 1983-06 Impact factor: 11.205

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Journal: Biochemistry Date: 1979-11-27 Impact factor: 3.162

10. Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.

Authors: A Schneider-Gädicke; E Schwarz
Journal: EMBO J Date: 1986-09 Impact factor: 11.598

110 in total

1. Ski interacts with the evolutionarily conserved SNW domain of Skip.

Authors: T Prathapam; C Kühne; M Hayman; L Banks
Journal: Nucleic Acids Res Date: 2001-09-01 Impact factor: 16.971

2. Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130.

Authors: K Smith-McCune; D Kalman; C Robbins; S Shivakumar; L Yuschenkoff; J M Bishop
Journal: Proc Natl Acad Sci U S A Date: 1999-06-08 Impact factor: 11.205

3. Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice.

Authors: G A Gulliver; R L Herber; A Liem; P F Lambert
Journal: J Virol Date: 1997-08 Impact factor: 5.103

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Authors: Oishee Chakrabarti; Sudhir Krishna
Journal: J Biosci Date: 2003-04 Impact factor: 1.826

5. Modulation of the cell division cycle by human papillomavirus type 18 E4.

Authors: Tomomi Nakahara; Akiko Nishimura; Masakazu Tanaka; Takaharu Ueno; Akinori Ishimoto; Hiroyuki Sakai
Journal: J Virol Date: 2002-11 Impact factor: 5.103

Review 6. Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses.

Authors: Aloysius J Klingelhutz; Ann Roman
Journal: Virology Date: 2012-01-27 Impact factor: 3.616

7. HUMAN PAPILLOMAVIRUS ASSOCIATION WITH HEAD AND NECK CANCERS: UNDERSTANDING VIRUS BIOLOGY AND USING IT IN THE DEVELOPMENT OF CANCER DIAGNOSTICS.

Authors: Katerina Strati; Paul F Lambert
Journal: Expert Opin Med Diagn Date: 2008-01-01

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Authors: Scott Balsitis; Fred Dick; Denis Lee; Linda Farrell; R Katherine Hyde; Anne E Griep; Nicholas Dyson; Paul F Lambert
Journal: J Virol Date: 2005-09 Impact factor: 5.103

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Journal: J Virol Date: 1993-06 Impact factor: 5.103