Literature DB >> 10359828

Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130.

K Smith-McCune1, D Kalman, C Robbins, S Shivakumar, L Yuschenkoff, J M Bishop.   

Abstract

To study intracellular pathways by which the human papillomavirus 16 oncogene E7 participates in carcinogenesis, we expressed an inducible chimera of E7 by fusion to the hormone-binding domain of the estrogen receptor. The chimeric protein (E7ER) transformed rodent fibroblast cell lines and induced DNA synthesis on addition of estradiol. In coimmunoprecipitation experiments, E7ER preferentially bound p130 when compared to p107 and pRb. After estradiol addition, E7ER localization changed to a more intense intranuclear staining. Induction of E7 function was not correlated with binding to p130 or pRb but rather with intranuclear localization and modest induction of binding to p107.

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Year:  1999        PMID： 10359828      PMCID： PMC22035          DOI： 10.1073/pnas.96.12.6999

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  54 in total

1.  Identification of human papillomavirus type 16 E7 protein by monoclonal antibodies.

Authors:  T Oltersdorf; K Seedorf; W Röwekamp; L Gissmann
Journal:  J Gen Virol       Date:  1987-11       Impact factor: 3.891

2.  G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4.

Authors:  X Mayol; J Garriga; X Graña
Journal:  Oncogene       Date:  1996-07-18       Impact factor: 9.867

3.  A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor.

Authors:  D Picard; S J Salser; K R Yamamoto
Journal:  Cell       Date:  1988-09-23       Impact factor: 41.582

4.  The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function.

Authors:  N J Webster; S Green; J R Jin; P Chambon
Journal:  Cell       Date:  1988-07-15       Impact factor: 41.582

5.  The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein.

Authors:  D Smotkin; F O Wettstein
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

6.  Identification of a transforming gene of human papillomavirus type 16.

Authors:  A Tanaka; T Noda; H Yajima; M Hatanaka; Y Ito
Journal:  J Virol       Date:  1989-03       Impact factor: 5.103

7.  Expression of human papillomavirus type 16 E7 gene induces DNA synthesis of rat 3Y1 cells.

Authors:  H Sato; A Furuno; K Yoshiike
Journal:  Virology       Date:  1989-01       Impact factor: 3.616

8.  The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene.

Authors:  K H Vousden; J Doniger; J A DiPaolo; D R Lowy
Journal:  Oncogene Res       Date:  1988-09

9.  Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

Authors:  G Matlashewski; J Schneider; L Banks; N Jones; A Murray; L Crawford
Journal:  EMBO J       Date:  1987-06       Impact factor: 11.598

10.  Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor.

Authors:  V Kumar; S Green; A Staub; P Chambon
Journal:  EMBO J       Date:  1986-09       Impact factor: 11.598
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  22 in total

1.  Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization.

Authors:  J Sage; G J Mulligan; L D Attardi; A Miller; S Chen; B Williams; E Theodorou; T Jacks
Journal:  Genes Dev       Date:  2000-12-01       Impact factor: 11.361

Review 2.  Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses.

Authors:  Aloysius J Klingelhutz; Ann Roman
Journal:  Virology       Date:  2012-01-27       Impact factor: 3.616

3.  Low- and high-risk human papillomavirus E7 proteins regulate p130 differently.

Authors:  Lisa Barrow-Laing; Wei Chen; Ann Roman
Journal:  Virology       Date:  2010-02-26       Impact factor: 3.616

4.  Conditionally activated E7 proteins of high-risk and low-risk human papillomaviruses induce S phase in postmitotic, differentiated human keratinocytes.

Authors:  N Sanjib Banerjee; Nicholas J Genovese; Francisco Noya; Wei-Ming Chien; Thomas R Broker; Louise T Chow
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

5.  Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle Arrest.

Authors:  M Giarrè; S Caldeira; I Malanchi; F Ciccolini; M J Leão; M Tommasino
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

6.  Nonconserved lysine residues attenuate the biological function of the low-risk human papillomavirus E7 protein.

Authors:  Nicholas J Genovese; Thomas R Broker; Louise T Chow
Journal:  J Virol       Date:  2011-03-16       Impact factor: 5.103

7.  Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways.

Authors:  E C Goodwin; D DiMaio
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

8.  Down regulation of the interleukin-8 promoter by human papillomavirus type 16 E6 and E7 through effects on CREB binding protein/p300 and P/CAF.

Authors:  Shih-Min Huang; D J McCance
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

9.  Study of viral integration of HPV-16 in young patients with LSIL.

Authors:  G Gallo; M Bibbo; L Bagella; A Zamparelli; F Sanseverino; M R Giovagnoli; A Vecchione; A Giordano
Journal:  J Clin Pathol       Date:  2003-07       Impact factor: 3.411

Review 10.  The papillomavirus E7 proteins.

Authors:  Ann Roman; Karl Munger
Journal:  Virology       Date:  2013-05-31       Impact factor: 3.616
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