OBJECTIVE: : To investigate whether the Mevion S250i with HYPERSCAN clinical proton system could be used for pre-clinical research with millimetric beams. METHODS: : The nozzle of the proton beam line, consisting of an energy modulation system (EMS) and an adaptive aperture (AA), was modelled with the TOPAS Monte Carlo Simulation Toolkit. With the EMS, the 230 MeV beam nominal range can be decreased in multiples of 2.1 mm. Monte Carlo dose calculations were performed in a mouse lung tumour CT image. The AA allows fields as small as 5 × 1 mm2 to be used for irradiation. The best plans to give 2 Gy to the tumour were derived from a set of discrete energies allowed by the EMS, different field sizes and beam directions. The final proton plans were compared to a precision photon irradiation plan. Treatment times were also assessed. RESULTS: : Seven different proton beam plans were investigated, with a good coverage to the tumour (D95 > 1.95 Gy, D5 < 2.3 Gy) and with potentially less damage to the organs at risk than the photon plan. For very small fields and low energies, the number of protons arriving to the target drops to 1-3%, nevertheless the treatment times would be below 5 s. CONCLUSION: : The proton plans made in this study, collimated by an AA, could be used for animal irradiation. ADVANCES IN KNOWLEDGE:: This is one of the first study to demonstrate the feasibility of pre-clinical research with a clinical proton beam with an adaptive aperture used to create small fields.
OBJECTIVE: : To investigate whether the Mevion S250i with HYPERSCAN clinical proton system could be used for pre-clinical research with millimetric beams. METHODS: : The nozzle of the proton beam line, consisting of an energy modulation system (EMS) and an adaptive aperture (AA), was modelled with the TOPAS Monte Carlo Simulation Toolkit. With the EMS, the 230 MeV beam nominal range can be decreased in multiples of 2.1 mm. Monte Carlo dose calculations were performed in a mouselung tumour CT image. The AA allows fields as small as 5 × 1 mm2 to be used for irradiation. The best plans to give 2 Gy to the tumour were derived from a set of discrete energies allowed by the EMS, different field sizes and beam directions. The final proton plans were compared to a precision photon irradiation plan. Treatment times were also assessed. RESULTS: : Seven different proton beam plans were investigated, with a good coverage to the tumour (D95 > 1.95 Gy, D5 < 2.3 Gy) and with potentially less damage to the organs at risk than the photon plan. For very small fields and low energies, the number of protons arriving to the target drops to 1-3%, nevertheless the treatment times would be below 5 s. CONCLUSION: : The proton plans made in this study, collimated by an AA, could be used for animal irradiation. ADVANCES IN KNOWLEDGE:: This is one of the first study to demonstrate the feasibility of pre-clinical research with a clinical proton beam with an adaptive aperture used to create small fields.
Authors: Christoph Greubel; Walter Assmann; Christian Burgdorf; Günther Dollinger; Guanghua Du; Volker Hable; Alexander Hapfelmeier; Ralf Hertenberger; Peter Kneschaurek; Dörte Michalski; Michael Molls; Sabine Reinhardt; Barbara Röper; Stefan Schell; Thomas E Schmid; Christian Siebenwirth; Tatiana Wenzl; Olga Zlobinskaya; Jan J Wilkens Journal: Radiat Environ Biophys Date: 2011-05-10 Impact factor: 1.925
Authors: Robert P Coppes; Christina T Muijs; Hette Faber; Sascha Gross; Jacobus M Schippers; Sytze Brandenburg; Johannes A Langendijk; Peter van Luijk Journal: Int J Radiat Oncol Biol Phys Date: 2011-05-24 Impact factor: 7.038
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Authors: John Wong; Elwood Armour; Peter Kazanzides; Iulian Iordachita; Erik Tryggestad; Hua Deng; Mohammad Matinfar; Christopher Kennedy; Zejian Liu; Timothy Chan; Owen Gray; Frank Verhaegen; Todd McNutt; Eric Ford; Theodore L DeWeese Journal: Int J Radiat Oncol Biol Phys Date: 2008-08-01 Impact factor: 7.038