Literature DB >> 1928102

Linkage disequilibrium between two highly polymorphic microsatellites.

R Sherrington1, G Melmer, M Dixon, D Curtis, B Mankoo, G Kalsi, H Gurling.   

Abstract

The PCR was used to amplify genomic DNA from two microsatellite (dC-dA)n.(dG-dT)n sequences found to be present in the same chromosome 5 genomic clone. Analysis of the haplotype frequencies of these two interspersed repeat sequences in individuals showed strong allelic association or linkage disequilibrium. Six alleles were found for p599 (CA)n with a PIC value of 0.71 and 8 alleles were seen for lambda 599 (CA)n with a PIC value of 0.74. The two microsatellites are separated by approximately 7 kb. Analysis of the length variations for the two microsatellites showed that they were positively correlated, a finding that has no obvious explanation. The strong linkage disequilibrium found demonstrates stability during evolution for these novel markers. Therefore they should be powerful new tools for studying genetic drift and admixture of populations. Furthermore, disequilibrium data from microsatellites can be used in the fine mapping and cloning of disease genes.

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Substances：

Year:  1991        PMID： 1928102      PMCID： PMC1683257     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  29 in total

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Authors:  P Vogt
Journal:  Hum Genet       Date:  1990-03       Impact factor: 4.132

2.  Approaches to localizing disease genes as applied to cystic fibrosis.

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Journal:  Nucleic Acids Res       Date:  1990-01-25       Impact factor: 16.971

3.  Linkage disequilibria between pairs of loci within a highly polymorphic region of chromosome 2Q.

Authors:  M Litt; L B Jorde
Journal:  Am J Hum Genet       Date:  1986-08       Impact factor: 11.025

4.  A high frequency of length polymorphisms in repeated sequences adjacent to Alu sequences.

Authors:  G Zuliani; H H Hobbs
Journal:  Am J Hum Genet       Date:  1990-05       Impact factor: 11.025

5.  Five polymorphic microsatellite VNTRs on the human X chromosome.

Authors:  J A Luty; Z Guo; H F Willard; D H Ledbetter; S Ledbetter; M Litt
Journal:  Am J Hum Genet       Date:  1990-04       Impact factor: 11.025

6.  A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands.

Authors:  X Estivill; M Farrall; P J Scambler; G M Bell; K M Hawley; N J Lench; G P Bates; H C Kruyer; P A Frederick; P Stanier
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7.  Nonuniform recombination within the human beta-globin gene cluster.

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Journal:  Am J Hum Genet       Date:  1984-11       Impact factor: 11.025

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Authors:  G Levinson; G A Gutman
Journal:  Mol Biol Evol       Date:  1987-05       Impact factor: 16.240

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Authors:  D Tautz; M Trick; G A Dover
Journal:  Nature       Date:  1986 Aug 14-20       Impact factor: 49.962

10.  Identification of the cystic fibrosis gene: chromosome walking and jumping.

Authors:  J M Rommens; M C Iannuzzi; B Kerem; M L Drumm; G Melmer; M Dean; R Rozmahel; J L Cole; D Kennedy; N Hidaka
Journal:  Science       Date:  1989-09-08       Impact factor: 47.728
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  16 in total

1.  Evidence for effective suppression of recombination in the chromosome 17q21 segment spanning RNU2-BRCA1.

Authors:  X Liu; D F Barker
Journal:  Am J Hum Genet       Date:  1999-05       Impact factor: 11.025

2.  Spectrum of nonrandom associations between microsatellite loci on human chromosome 11p15.

Authors:  C Zapata; S Rodríguez; G Visedo; F Sacristán
Journal:  Genetics       Date:  2001-07       Impact factor: 4.562

3.  Rapid diagnosis of infantile spinal muscular atrophy by direct amplification of amniocyte and CVS DNA.

Authors:  A MacKenzie; A Besner; N Roy
Journal:  J Med Genet       Date:  1993-02       Impact factor: 6.318

4.  Molecular and statistical approaches to the detection and correction of errors in genotype databases.

Authors:  L M Brzustowicz; C Mérette; X Xie; L Townsend; T C Gilliam; J Ott
Journal:  Am J Hum Genet       Date:  1993-11       Impact factor: 11.025

5.  Linkage disequilibrium patterns vary with chromosomal location: a case study from the von Willebrand factor region.

Authors:  W S Watkins; R Zenger; E O'Brien; D Nyman; A W Eriksson; M Renlund; L B Jorde
Journal:  Am J Hum Genet       Date:  1994-08       Impact factor: 11.025

6.  Linkage mapping of the spinal muscular atrophy gene.

Authors:  A H Burghes; S E Ingraham; Z Kóte-Jarai; S Rosenfeld; N Herta; N Nadkarni; C J DiDonato; J Carpten; O Hurko; J Florence
Journal:  Hum Genet       Date:  1994-03       Impact factor: 4.132

7.  Apparent SMA I unlinked to 5q.

Authors:  J M Cobben; H Scheffer; M de Visser; J H Begeer; W M Molenaar; G van der Steege; C H Buys; G J van Ommen; L P Ten Kate
Journal:  J Med Genet       Date:  1994-03       Impact factor: 6.318

8.  Dinucleotide repeat polymorphisms at the lipoprotein lipase (LPL) locus.

Authors:  T M Narcisi; M C Schotz; J Scott; C C Shoulders
Journal:  Hum Genet       Date:  1993-10-01       Impact factor: 4.132

9.  Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.

Authors:  L B Jorde; W S Watkins; M Carlson; J Groden; H Albertsen; A Thliveris; M Leppert
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

10.  Genetic linkage analysis of Canadian spinal muscular atrophy kindreds using flanking microsatellite 5q13 polymorphisms.

Authors:  A MacKenzie; N Roy; A Besner; G Mettler; P Jacob; R Korneluk; L Surh
Journal:  Hum Genet       Date:  1993-01       Impact factor: 4.132
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