Literature DB >> 2988335

Melanesians and Polynesians share a unique alpha-thalassemia mutation.

A V Hill, D K Bowden, R J Trent, D R Higgs, S J Oppenheimer, S L Thein, K N Mickleson, D J Weatherall, J B Clegg.   

Abstract

Several genetic markers that provide information on population migrations and affinities have been detected by studies of proteins and cellular antigens in blood. Analysis of DNA polymorphisms promises to yield many further population markers, and we report here the distribution of a new alpha-globin gene deletion (-alpha 3.7 III) detected by a restriction enzyme mapping. This is found frequently in Melanesians and Polynesians but not in five other populations in which alpha-thalassemia is prevalent. We used restriction enzyme haplotype analysis to support a single origin for this mutation and propose that it is a useful population marker. Its geographical distribution supports a route through Island Melanesia for the colonizers of Polynesia.

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Year:  1985        PMID： 2988335      PMCID： PMC1684581     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  30 in total

1.  Independent recombination events between the duplicated human alpha globin genes; implications for their concerted evolution.

Authors:  D R Higgs; A V Hill; D K Bowden; D J Weatherall; J B Clegg
Journal:  Nucleic Acids Res       Date:  1984-09-25       Impact factor: 16.971

2.  Highly variable regions of DNA flank the human alpha globin genes.

Authors:  D R Higgs; S E Goodbourn; J S Wainscoat; J B Clegg; D J Weatherall
Journal:  Nucleic Acids Res       Date:  1981-09-11       Impact factor: 16.971

Review 3.  Polymorphism and molecular pathology of the human beta-globin gene.

Authors:  S H Orkin; S E Antonarakis; H H Kazazian
Journal:  Prog Hematol       Date:  1983

Review 4.  Alpha-thalassemia.

Authors:  D R Higgs; D J Weatherall
Journal:  Curr Top Hematol       Date:  1983

5.  Population and genetic studies suggest a single origin for the Indian deletion beta thalassaemia.

Authors:  S L Thein; J M Old; J S Wainscoat; M Petrou; B Modell; D J Weatherall
Journal:  Br J Haematol       Date:  1984-06       Impact factor: 6.998

6.  Gamma thalassemia resulting from the deletion of a gamma-globin gene.

Authors:  P K Sukumaran; T Nakatsuji; M B Gardiner; A L Reese; J G Gilman; T H Huisman
Journal:  Nucleic Acids Res       Date:  1983-07-11       Impact factor: 16.971

7.  Origin of the beta S-globin gene in blacks: the contribution of recurrent mutation or gene conversion or both.

Authors:  S E Antonarakis; C D Boehm; G R Serjeant; C E Theisen; G J Dover; H H Kazazian
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

8.  The rare alpha-thalassemia-1 of blacks is a zeta alpha-thalassemia-1 associated with deletion of all alpha- and zeta-globin genes.

Authors:  A E Felice; M P Cleek; K McKie; V McKie; T H Huisman
Journal:  Blood       Date:  1984-05       Impact factor: 22.113

9.  GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY, THALASSAEMIA, AND ABNORMAL HAEMOGLOBINS IN THE PHILIPPINES.

Authors:  A G MOTULSKY; E STRANSKY; G R FRASER
Journal:  J Med Genet       Date:  1964-12       Impact factor: 6.318

10.  The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.

Authors:  J Lauer; C K Shen; T Maniatis
Journal:  Cell       Date:  1980-05       Impact factor: 41.582
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  32 in total

1.  The molecular basis of thalassemias.

Authors:  S Fucharoen; P Winichagoon
Journal:  Indian J Pediatr       Date:  1989 Nov-Dec       Impact factor: 1.967

Review 2.  Out-of-Africa, the peopling of continents and islands: tracing uniparental gene trees across the map.

Authors:  Stephen Oppenheimer
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2012-03-19       Impact factor: 6.237

3.  Globin genes in Micronesia: origins and affinities of Pacific Island peoples.

Authors:  D F O'Shaughnessy; A V Hill; D K Bowden; D J Weatherall; J B Clegg
Journal:  Am J Hum Genet       Date:  1990-01       Impact factor: 11.025

4.  Extremely high frequencies of alpha-globin gene deletion in Madang and on Kar Kar Island, Papua New Guinea.

Authors:  P T Yenchitsomanus; K M Summers; K K Bhatia; J Cattani; P G Board
Journal:  Am J Hum Genet       Date:  1985-07       Impact factor: 11.025

5.  Frequency and molecular types of deletional alpha-thalassemia in Egypt.

Authors:  A Novelletto; M Hafez; A Di Rienzo; L Felicetti; G Deidda; Z el Morsi; Y al-Tonbary; M el-Ziny; N Abd-el-Gelil; L Terrenato
Journal:  Hum Genet       Date:  1989-02       Impact factor: 4.132

6.  Alpha-thalassemia haplotypes in the Algerian population.

Authors:  T Henni; F Morlé; B Lopez; P Colonna; J Godet
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

Review 7.  The molecular pathology of the alpha globin genes.

Authors:  D J Weatherall; D R Higgs; J B Clegg
Journal:  Br J Cancer Suppl       Date:  1988-12

8.  A population genetic survey of the haptoglobin polymorphism in Melanesians by DNA analysis.

Authors:  A V Hill; D K Bowden; J Flint; D B Whitehouse; D A Hopkinson; S J Oppenheimer; S W Serjeantson; J B Clegg
Journal:  Am J Hum Genet       Date:  1986-03       Impact factor: 11.025

9.  Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.

Authors:  D R Higgs; J S Wainscoat; J Flint; A V Hill; S L Thein; R D Nicholls; H Teal; H Ayyub; T E Peto; A G Falusi
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

Review 10.  Alpha-thalassaemia.

Authors:  Cornelis L Harteveld; Douglas R Higgs
Journal:  Orphanet J Rare Dis       Date:  2010-05-28       Impact factor: 4.123
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