Literature DB >> 2109582

In vitro investigation of BK-218, a new oral and parenteral cephalosporin.

I Szabó1, J Barabás, A Tar, L Kiss, M Filep, T Schmidt, K Marossy, B Tóth-Martinez, G Barabás, F Hernádi.   

Abstract

The antibacterial activity of BK-218 was similar to that of cefamandole when it was tested against several laboratory strains. The inhibiting effect of BK-218 was greater than that of cephalexin and cefoxitin on penicillin-binding proteins of Escherichia coli HB101. This result was in close correlation with the relative inhibition of radiolabeled glucosamine incorporation (greatest with BK-218) and with the lytic effect (most intensive with BK-218). BK-218 proved to be a good inhibitor for all five of the beta-lactamases that were investigated, although two enzymes (Enterobacter cloacae P99 and Pseudomonas aeruginosa Cilote) hydrolyzed it to some extent.

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Year:  1990        PMID： 2109582      PMCID： PMC171585          DOI： 10.1128/AAC.34.2.349

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

1.  Layered distribution, according to age, within the cell wall of bacillus subtilis.

Authors:  H M Pooley
Journal:  J Bacteriol       Date:  1976-03       Impact factor: 3.490

2.  A direct spectrophotometric assay and determination of Michaelis constants for the beta-lactamase reaction.

Authors:  A Samuni
Journal:  Anal Biochem       Date:  1975-01       Impact factor: 3.365

3.  The classification and terminology of enzymes that hydrolyze beta-lactam antibiotics.

Authors:  R B Sykes
Journal:  J Infect Dis       Date:  1982-05       Impact factor: 5.226

4.  Properties of three carbenicillin-hydrolysing beta-lactamases (CARB) from Pseudomonas aeruginosa: identification of a new enzyme.

Authors:  R Labia; M Guionie; M Barthélémy
Journal:  J Antimicrob Chemother       Date:  1981-01       Impact factor: 5.790

5.  Triggering of autolytic cell wall degradation in Escherichia coli by beta-lactam antibiotics.

Authors:  K Kitano; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

6.  Properties of the penicillin-binding proteins of Escherichia coli K12,.

Authors:  B G Spratt
Journal:  Eur J Biochem       Date:  1977-01

7.  Cefatrizine activity compared with that of other cephalosporins.

Authors:  H C Neu; K P Fu
Journal:  Antimicrob Agents Chemother       Date:  1979-02       Impact factor: 5.191

8.  Reversible inhibitors of penicillinases.

Authors:  P A Kiener; S G Waley
Journal:  Biochem J       Date:  1978-01-01       Impact factor: 3.857

9.  Cell wall turnover in batch and chemostat cultures of Bacillus subtilis.

Authors:  W R De Boer; F J Kruyssen; J T Wouters
Journal:  J Bacteriol       Date:  1981-01       Impact factor: 3.490

10.  Identification of the lethal target of benzylpenicillin in Streptococcus faecalis by in vivo penicillin binding studies.

Authors:  R Fontana; P Canepari; G Satta; J Coyette
Journal:  Nature       Date:  1980-09-04       Impact factor: 49.962
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  1 in total

1.  Antibacterial activity of the investigational oral and parenteral cephalosporin BK-218.

Authors:  D M Johnson; R N Jones
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1992-02       Impact factor: 3.267
  1 in total

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