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Literature DB >> 907337

In vitro activity of cefaclor, a new orally administered cephalosporin antibiotic.

Abstract

The in vitro antibacterial activity of cefaclor, cephalothin, and cephalexin against 261 clinical isolates of Staphylococcus aureus and Enterobacteriaceae was compared. Cefaclor and cephalexin were about equally active against S. aureus. Cefaclor was the most active cephalosporin against Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae. The effect on the antimicrobial activity using a relatively high and low inoculum was pronounced for cefaclor when compared with that of cephalothin.

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Year: 1977 PMID： 907337 PMCID： PMC429936 DOI： 10.1128/AAC.12.3.442

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

1 in total

1. Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.

Authors: N J Bill; J A Washington
Journal: Antimicrob Agents Chemother Date: 1977-03 Impact factor: 5.191

1 in total

11 in total

10. [Experience with cefaclor in the treatment of ear, nose and throat infections. Indications for cefaclor therapy (author's transl)].

Authors: P Federspil; R Bach; C Weich; H J Wilhelm; E Tiesler; W Schätzle
Journal: Infection Date: 1979 Impact factor: 3.553

In vitro activity of cefaclor, a new orally administered cephalosporin antibiotic.

1. Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.

1. Cefaclor: summary of clinical experience.

2. Summary of laboratory studies on the antibacterial activity of cefaclor.

3. Concentration relationships of cefaclor in serum, interstitial fluid, bile, and urine of dogs.

4. Pharmacokinetics of cefaclor in patients with end stage renal disease and during hemodialysis.

Review 5. The cephalosporin antibiotics in pediatric therapy.

6. Pharmacology of cefaclor in normal volunteers and patients with renal failure.

7. Susceptibility of Staphylococcus aureus to cefaclor and cephalothin: laboratory and clinical studies.

8. Cefaclor versus amoxicillin in the treatment of bacterial pneumonia: a comparative double-blind study.

9. Pharmacological evaluation of cefaclor in volunteers.

10. [Experience with cefaclor in the treatment of ear, nose and throat infections. Indications for cefaclor therapy (author's transl)].