Mohammad Reza Sobhan1, Masoud Mahdinezhad-Yazdi2, Kazem Aghili3, Masoud Zare-Shehneh4, Shohreh Rastegar5, Jalal Sadeghizadeh-Yazdi6, Hossein Neamatzadeh4. 1. Department of Orthopedics, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2. Department of Orthopedics, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 3. Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 4. Department of Medical Genetics, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 5. Department of Anesthesiology, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 6. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
OBJECTIVE: A comprehensive search on electronic databases was conducted to identify all eligible studies of TNF-α polymorphisms and knee osteoarthritis (OA). METHODS: Eight studies on TNF-α -308 G > A and three on TNF-α -238G > A polymorphism were identified. RESULTS: Overall, the pooled ORs indicated that neither TNF-α -238G > A nor -238G > A polymorphism was associated with knee OA risk. Similarly, in the stratified analysis by ethnicity, no significant association was found. CONCLUSION: This meta-analysis results inconsistent with the previous meta-analyses showed that the TNF-α -308 G > A and -238G > A polymorphisms may not be associated with the susceptibility to knee OA.
OBJECTIVE: A comprehensive search on electronic databases was conducted to identify all eligible studies of TNF-α polymorphisms and knee osteoarthritis (OA). METHODS: Eight studies on TNF-α -308 G > A and three on TNF-α -238G > A polymorphism were identified. RESULTS: Overall, the pooled ORs indicated that neither TNF-α -238G > A nor -238G > A polymorphism was associated with knee OA risk. Similarly, in the stratified analysis by ethnicity, no significant association was found. CONCLUSION: This meta-analysis results inconsistent with the previous meta-analyses showed that the TNF-α -308 G > A and -238G > A polymorphisms may not be associated with the susceptibility to knee OA.
Authors: José Francisco Muñoz-Valle; Edith Oregón-Romero; Héctor Rangel-Villalobos; Gloria Esther Martínez-Bonilla; Eduardo Castañeda-Saucedo; Lorenzo Salgado-Goytia; Marco Antonio Leyva-Vázquez; Berenice Illades-Aguiar; Luz del Carmen Alarcón-Romero; Mónica Espinoza-Rojo; Isela Parra-Rojas Journal: Clin Exp Med Date: 2012-10-30 Impact factor: 3.984
Authors: Masoud Mahdinezhad Yazdi; Mohamad H Jamalaldini; Mohammad R Sobhan; Mohammadali Jafari; Mahta Mazaheri; Masoud Zare-Shehneh; Hossein Neamatzadeh Journal: Arch Bone Jt Surg Date: 2017-11