Hossein Ahrar1, Kazem Aghili1, Mohammad Reza Sobhan2, Masoud Mahdinezhad-Yazdi2, Mohammad Javad Akbarian-Bafghi3, Hossein Neamatzadeh4,5. 1. Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2. Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 3. Department of Healthcare Management, Bam University of Medical Sciences, Bam, Iran. 4. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 5. Maternal and Neonatal Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
OBJECTIVE: To evaluate the association of ESR1 rs2234693 and rs9340799 polymorphisms with radiographic defined knee osteoarthritis (OA), a case-control and meta-analysis was performed. METHODS: A total of 25 case-control studies with 7,144 cases and 8,468 controls with were included. RESULTS: There was a significant association between rs2234693 polymorphism and radiographic knee OA under heterozygote model (CT vs. TT: OR = 1.164, 95% CI 1.053-1.286, p = 0.003). However, there was no association between rs9340799 and radiographic knee OA. In subgroup analysis by ethnicity, risk estimates were not augmented. CONCLUSIONS: Our results showed that the ESR1 rs2234693 polymorphism might be associated with radiographic defined knee OA, but not rs9340799.
OBJECTIVE: To evaluate the association of ESR1 rs2234693 and rs9340799 polymorphisms with radiographic defined knee osteoarthritis (OA), a case-control and meta-analysis was performed. METHODS: A total of 25 case-control studies with 7,144 cases and 8,468 controls with were included. RESULTS: There was a significant association between rs2234693 polymorphism and radiographic knee OA under heterozygote model (CT vs. TT: OR = 1.164, 95% CI 1.053-1.286, p = 0.003). However, there was no association between rs9340799 and radiographic knee OA. In subgroup analysis by ethnicity, risk estimates were not augmented. CONCLUSIONS: Our results showed that the ESR1 rs2234693 polymorphism might be associated with radiographic defined knee OA, but not rs9340799.
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Authors: J A Riancho; C García-Ibarbia; A Gravani; E V A Raine; C Rodríguez-Fontenla; A Soto-Hermida; I Rego-Perez; A W Dodd; J J Gómez-Reino; M T Zarrabeitia; C M Garcés; A Carr; F Blanco; A González; J Loughlin Journal: Osteoarthritis Cartilage Date: 2010-04-22 Impact factor: 6.576
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