Masoud Mahdinejad-Yazdi1, Mohammad Reza Sobhan1, Seyed Alireza Dastgheib2, Reza Bahrami3, Seyed Hossein Shaker4, Hamid Mirjalili5, Jalal Sadeghizadeh-Yazdi6, Masoud Zare-Shehneh7, Hossein Neamatzadeh7,8. 1. Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 3. Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Department of Emergency Medicine, Iran University of Medical Sciences, Tehran, Iran. 5. Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 6. Department of Food Science and Technology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 7. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 8. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
OBJECTIVE: We performed a meta-analysis of all eligible studies on the association of TNF-α -308G>A polymorphism with risk of Ankylosing spondylitis (AS). METHODS: A comprehensive literature research was performed in online databases. RESULTS: A total of 28 studies with 4489 cases and 5919 controls were included. Pooled ORs showed a significant association between TNF-α -308G>A polymorphism and risk of AS. Moreover, stratified analysis by ethnicity showed a significant association between TNF-α -308G>A polymorphism and AS risk in Asians, Caucasians and Mixed populations, but not in Chinese population. CONCLUSION: This meta-analysis suggested that the TNF-α -308G>A polymorphism was associated with AS risk.
OBJECTIVE: We performed a meta-analysis of all eligible studies on the association of TNF-α -308G>A polymorphism with risk of Ankylosing spondylitis (AS). METHODS: A comprehensive literature research was performed in online databases. RESULTS: A total of 28 studies with 4489 cases and 5919 controls were included. Pooled ORs showed a significant association between TNF-α -308G>A polymorphism and risk of AS. Moreover, stratified analysis by ethnicity showed a significant association between TNF-α -308G>A polymorphism and AS risk in Asians, Caucasians and Mixed populations, but not in Chinese population. CONCLUSION: This meta-analysis suggested that the TNF-α -308G>A polymorphism was associated with AS risk.
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