Kazem Aghili1, Mohammad Reza Sobhan2, Masoud Mehdinezhad-Yazdi2, Mohammadali Jafari3, Seyed Mohsen Miresmaeili4, Shohreh Rastegar5, Mahta Mazaheri6, Hossein Neamatzadeh6. 1. Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2. Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 3. Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 4. Department of Biology, Science and Art University, Yazd, Iran. 5. Department of Anesthesiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 6. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
OBJECTIVE: To assess the association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis (OA), a systematic review and meta-analysis was conducted. METHODS: A total of 17 relevant case-control studies with 7424 cases and 11,310 controls was collected from several electronic databases up to June 2018. RESULTS: The pooled results showed that GDF-5 rs143383 polymorphism was significantly associated with radiographic defined knee OA in overall and stratified analysis by ethnicity, source of controls and genotyping techniques. CONCLUSIONS: The GDF-5 rs143383 polymorphism might be used as a relevant risk estimate for radiographic defined Knee OA.
OBJECTIVE: To assess the association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis (OA), a systematic review and meta-analysis was conducted. METHODS: A total of 17 relevant case-control studies with 7424 cases and 11,310 controls was collected from several electronic databases up to June 2018. RESULTS: The pooled results showed that GDF-5 rs143383 polymorphism was significantly associated with radiographic defined knee OA in overall and stratified analysis by ethnicity, source of controls and genotyping techniques. CONCLUSIONS: The GDF-5 rs143383 polymorphism might be used as a relevant risk estimate for radiographic defined Knee OA.
Authors: R B A Vaes; F Rivadeneira; J M Kerkhof; A Hofman; H A P Pols; A G Uitterlinden; J B J van Meurs Journal: Ann Rheum Dis Date: 2008-11-24 Impact factor: 19.103
Authors: Masoud Mahdinezhad Yazdi; Mohamad H Jamalaldini; Mohammad R Sobhan; Mohammadali Jafari; Mahta Mazaheri; Masoud Zare-Shehneh; Hossein Neamatzadeh Journal: Arch Bone Jt Surg Date: 2017-11
Authors: Vikram Swaminathan; Matthew J Parkes; Michael J Callaghan; Terence W O'Neill; Richard Hodgson; Andrew D Gait; David T Felson Journal: BMC Musculoskelet Disord Date: 2017-08-10 Impact factor: 2.362