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Literature DB >> 29795750

What Do You Get from DNA-Encoded Libraries?

Abstract

Use of DNA-encoded libraries (DELs) in the pharmaceutical industry has rapidly increased. We discuss what to expect when you run a DEL screen and contemplate guidelines for library design. Additionally, we consider some visionary work and extrapolate to the future.

Year: 2018 PMID： 29795750 PMCID： PMC5949729 DOI： 10.1021/acsmedchemlett.8b00128

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

12 in total

1. Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor.

Authors: Zining Wu; Todd L Graybill; Xin Zeng; Michael Platchek; Jean Zhang; Vera Q Bodmer; David D Wisnoski; Jianghe Deng; Frank T Coppo; Gang Yao; Alex Tamburino; Genaro Scavello; G Joseph Franklin; Sibongile Mataruse; Katie L Bedard; Yun Ding; Jing Chai; Jennifer Summerfield; Paolo A Centrella; Jeffrey A Messer; Andrew J Pope; David I Israel
Journal: ACS Comb Sci Date: 2015-12-03 Impact factor: 3.784

2. Design, synthesis and selection of DNA-encoded small-molecule libraries.

Authors: Matthew A Clark; Raksha A Acharya; Christopher C Arico-Muendel; Svetlana L Belyanskaya; Dennis R Benjamin; Neil R Carlson; Paolo A Centrella; Cynthia H Chiu; Steffen P Creaser; John W Cuozzo; Christopher P Davie; Yun Ding; G Joseph Franklin; Kurt D Franzen; Malcolm L Gefter; Steven P Hale; Nils J V Hansen; David I Israel; Jinwei Jiang; Malcolm J Kavarana; Michael S Kelley; Christopher S Kollmann; Fan Li; Kenneth Lind; Sibongile Mataruse; Patricia F Medeiros; Jeffrey A Messer; Paul Myers; Heather O'Keefe; Matthew C Oliff; Cecil E Rise; Alexander L Satz; Steven R Skinner; Jennifer L Svendsen; Lujia Tang; Kurt van Vloten; Richard W Wagner; Gang Yao; Baoguang Zhao; Barry A Morgan
Journal: Nat Chem Biol Date: 2009-08-02 Impact factor: 15.040

3. A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells.

Authors: A J You; R J Jackman; G M Whitesides; S L Schreiber
Journal: Chem Biol Date: 1997-12

4. DNA Encoded Library Selections and Insights Provided by Computational Simulations.

Authors: Alexander L Satz
Journal: ACS Chem Biol Date: 2015-07-27 Impact factor: 5.100

Review 5. DNA-encoded chemistry: enabling the deeper sampling of chemical space.

Authors: Robert A Goodnow; Christoph E Dumelin; Anthony D Keefe
Journal: Nat Rev Drug Discov Date: 2016-12-09 Impact factor: 84.694

6. Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

Authors: Seungkirl Ahn; Alem W Kahsai; Biswaranjan Pani; Qin-Ting Wang; Shuai Zhao; Alissa L Wall; Ryan T Strachan; Dean P Staus; Laura M Wingler; Lillian D Sun; Justine Sinnaeve; Minjung Choi; Ted Cho; Thomas T Xu; Gwenn M Hansen; Michael B Burnett; Jane E Lamerdin; Daniel L Bassoni; Bryant J Gavino; Gitte Husemoen; Eva K Olsen; Thomas Franch; Stefano Costanzi; Xin Chen; Robert J Lefkowitz
Journal: Proc Natl Acad Sci U S A Date: 2017-01-27 Impact factor: 11.205

7. DNA Compatible Multistep Synthesis and Applications to DNA Encoded Libraries.

Authors: Alexander Lee Satz; Jianping Cai; Yi Chen; Robert Goodnow; Felix Gruber; Agnieszka Kowalczyk; Ann Petersen; Goli Naderi-Oboodi; Lucja Orzechowski; Quentin Strebel
Journal: Bioconjug Chem Date: 2015-07-10 Impact factor: 4.774

8. Discovering Drugs with DNA-Encoded Library Technology: From Concept to Clinic with an Inhibitor of Soluble Epoxide Hydrolase.

Authors: Svetlana L Belyanskaya; Yun Ding; James F Callahan; Aili L Lazaar; David I Israel
Journal: Chembiochem Date: 2017-03-24 Impact factor: 3.164

9. ChEMBL: a large-scale bioactivity database for drug discovery.

Authors: Anna Gaulton; Louisa J Bellis; A Patricia Bento; Jon Chambers; Mark Davies; Anne Hersey; Yvonne Light; Shaun McGlinchey; David Michalovich; Bissan Al-Lazikani; John P Overington
Journal: Nucleic Acids Res Date: 2011-09-23 Impact factor: 16.971

10. An Integrated Microfluidic Processor for DNA-Encoded Combinatorial Library Functional Screening.

Authors: Andrew B MacConnell; Alexander K Price; Brian M Paegel
Journal: ACS Comb Sci Date: 2017-02-22 Impact factor: 3.784

16 in total

1. Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.

Authors: Pei-Pei Kung; Patrick Bingham; Benjamin J Burke; Qiuxia Chen; Xuemin Cheng; Ya-Li Deng; Dengfeng Dou; Junli Feng; Gary M Gallego; Michael R Gehring; Stephan K Grant; Samantha Greasley; Anthony R Harris; Karen A Maegley; Jordan Meier; Xiaoyun Meng; Jose L Montano; Barry A Morgan; Brigitte S Naughton; Prakash B Palde; Thomas A Paul; Paul Richardson; Sylvie Sakata; Alex Shaginian; William K Sonnenburg; Chakrapani Subramanyam; Sergei Timofeevski; Jinqiao Wan; Wen Yan; Albert E Stewart
Journal: ACS Med Chem Lett Date: 2020-04-10 Impact factor: 4.345

2. A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis.

Authors: Anokha S Ratnayake; Mark E Flanagan; Timothy L Foley; Justin D Smith; Jillian G Johnson; Justin Bellenger; Justin I Montgomery; Brian M Paegel
Journal: ACS Comb Sci Date: 2019-09-06 Impact factor: 3.784

3. Kinetically guided radical-based synthesis of C(sp³)-C(sp³) linkages on DNA.

Authors: Jie Wang; Helena Lundberg; Shota Asai; Pedro Martín-Acosta; Jason S Chen; Stephen Brown; William Farrell; Russell G Dushin; Christopher J O'Donnell; Anokha S Ratnayake; Paul Richardson; Zhiqing Liu; Tian Qin; Donna G Blackmond; Phil S Baran
Journal: Proc Natl Acad Sci U S A Date: 2018-06-26 Impact factor: 11.205

4. RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis.

Authors: Dillon T Flood; Xuejing Zhang; Xiang Fu; Zhenxiang Zhao; Shota Asai; Brittany B Sanchez; Emily J Sturgell; Julien C Vantourout; Paul Richardson; Mark E Flanagan; David W Piotrowski; Dominik K Kölmel; Jinqiao Wan; Mei-Hsuan Tsai; Jason S Chen; Phil S Baran; Philip E Dawson
Journal: Angew Chem Int Ed Engl Date: 2020-03-11 Impact factor: 15.336

5. Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis.

Authors: James P Phelan; Simon B Lang; Jaehoon Sim; Simon Berritt; Andrew J Peat; Katelyn Billings; Lijun Fan; Gary A Molander
Journal: J Am Chem Soc Date: 2019-02-12 Impact factor: 15.419

Review 6. DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges.

Authors: Adrián Gironda-Martínez; Etienne J Donckele; Florent Samain; Dario Neri
Journal: ACS Pharmacol Transl Sci Date: 2021-06-14

7. Analysis of DNA-Encoded Library Screening Data: Selection of Molecules for Synthesis.

Authors: Alexander L Satz; Weiren Cui
Journal: Methods Mol Biol Date: 2022

8. Water-Compatible Cycloadditions of Oligonucleotide-Conjugated Strained Allenes for DNA-Encoded Library Synthesis.

Authors: Matthias V Westphal; Liam Hudson; Jeremy W Mason; Johan A Pradeilles; Frédéric J Zécri; Karin Briner; Stuart L Schreiber
Journal: J Am Chem Soc Date: 2020-04-16 Impact factor: 15.419

9. Trends in Hit-to-Lead Optimization Following DNA-Encoded Library Screens.

Authors: Christopher A Reiher; David P Schuman; Nicholas Simmons; Scott E Wolkenberg
Journal: ACS Med Chem Lett Date: 2021-02-11 Impact factor: 4.345

10. Merging C(sp³)-H activation with DNA-encoding.

Authors: Zhoulong Fan; Shuai Zhao; Tao Liu; Peng-Xiang Shen; Zi-Ning Cui; Zhe Zhuang; Qian Shao; Jason S Chen; Anokha S Ratnayake; Mark E Flanagan; Dominik K Kölmel; David W Piotrowski; Paul Richardson; Jin-Quan Yu
Journal: Chem Sci Date: 2020-09-07 Impact factor: 9.825