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Literature DB >> 30753065

Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis.

James P Phelan¹, Simon B Lang¹, Jaehoon Sim¹, Simon Berritt¹, Andrew J Peat², Katelyn Billings³, Lijun Fan³, Gary A Molander¹.

Abstract

DNA-encoded library (DEL) technology is a powerful tool commonly used by the pharmaceutical industry for the identification of compounds with affinity to biomolecular targets. Success in this endeavor lies in sampling diverse chemical libraries. However, current DELs tend to be deficient in C(sp3) carbon counts. We report unique solutions to the challenge of increasing both the chemical diversity of these libraries and their C(sp3) carbon counts by merging Ni/photoredox dual catalytic C(sp2)-C(sp3) cross-coupling as well as photoredox-catalyzed radical/polar crossover alkylation protocols with DELs. The successful integration of multiple classes of radical sources enables the rapid incorporation of a diverse set of alkyl fragments.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2019 PMID： 30753065 PMCID： PMC6393171 DOI： 10.1021/jacs.9b00669

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

76 in total

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Review 9. Advances in transition metal (Pd, Ni, Fe)-catalyzed cross-coupling reactions using alkyl-organometallics as reaction partners.

Authors: Ranjan Jana; Tejas P Pathak; Matthew S Sigman
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2. Considerations for Achieving Maximized DNA Recovery in Solid-Phase DNA-Encoded Library Synthesis.

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3. DNA Barcoding a Complete Matrix of Stereoisomeric Small Molecules.

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5. RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis.

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