Literature DB >> 2939459

The immunoglobulin heavy chain enhancer is stimulated by the adenovirus type 2 E1A products in mouse fibroblasts.

E Borrelli, R Hen, C Wasylyk, B Wasylyk, P Chambon.   

Abstract

In contrast with our previous results (Hen, R., Borrelli, E. & Chambon, P. (1985) Science 230, 1391-1394), which demonstrated that the mouse immunoglobulin heavy chain transcriptional enhancer is repressed in lymphoid cells by the products of the adenovirus type 2 E1A transcription unit, we show here that these products activate the same enhancer in mouse fibroblast L cell lines that contain stably integrated copies of a recombinant in which the enhancer is inserted upstream from the chicken conalbumin promoter. In addition, competition experiments suggest that the activity of the heavy chain enhancer may be repressed by a trans-acting factor in mouse L cells. We speculate that the E1A products may prevent the action of this cellular repressor in these cells.

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Year:  1986        PMID： 2939459      PMCID： PMC323403          DOI： 10.1073/pnas.83.9.2846

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  A trans-acting factor is responsible for the simian virus 40 enhancer activity in vitro.

Authors:  P Sassone-Corsi; A Wildeman; P Chambon
Journal:  Nature       Date:  1985 Feb 7-13       Impact factor: 49.962

2.  Adenovirus E1a proteins repress transcription from the SV40 early promoter.

Authors:  A Velcich; E Ziff
Journal:  Cell       Date:  1985-03       Impact factor: 41.582

3.  Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eucaryotic cells.

Authors:  K Blochlinger; H Diggelmann
Journal:  Mol Cell Biol       Date:  1984-12       Impact factor: 4.272

4.  Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription.

Authors:  E Borrelli; R Hen; P Chambon
Journal:  Nature       Date:  1984 Dec 13-19       Impact factor: 49.962

5.  Epidermal growth factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes.

Authors:  L M Matrisian; G Rautmann; B E Magun; R Breathnach
Journal:  Nucleic Acids Res       Date:  1985-02-11       Impact factor: 16.971

6.  HeLa cell beta-tubulin gene transcription is stimulated by adenovirus 5 in parallel with viral early genes by an E1a-dependent mechanism.

Authors:  R Stein; E B Ziff
Journal:  Mol Cell Biol       Date:  1984-12       Impact factor: 4.272

7.  Repression of the immunoglobulin heavy chain enhancer by the adenovirus-2 E1A products.

Authors:  R Hen; E Borrelli; P Chambon
Journal:  Science       Date:  1985-12-20       Impact factor: 47.728

8.  Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors.

Authors:  H R Schöler; P Gruss
Journal:  EMBO J       Date:  1985-11       Impact factor: 11.598

9.  Mouse histocompatibility genes: structure and organisation of a Kd gene.

Authors:  S Kvist; L Roberts; B Dobberstein
Journal:  EMBO J       Date:  1983       Impact factor: 11.598

10.  Induction of immunoglobulin gene expression in mouse fibroblasts by cycloheximide treatment.

Authors:  T Ishihara; A Kudo; T Watanabe
Journal:  J Exp Med       Date:  1984-12-01       Impact factor: 14.307
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  26 in total

1.  Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A trans-activation.

Authors:  P Sassone-Corsi
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

2.  E1A-dependent trans-activation of the c-fos promoter requires the TATAA sequence.

Authors:  M C Simon; R J Rooney; T M Fisch; N Heintz; J R Nevins
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

3.  DNA octamer element can confer E1A trans-activation, and adenovirus infection results in a stimulation of the DNA-binding activity of OTF-1/NFIII factor.

Authors:  S P Chellappan; J R Nevins
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

4.  Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

Authors:  J L Imler; C Lemaire; C Wasylyk; B Wasylyk
Journal:  Mol Cell Biol       Date:  1987-07       Impact factor: 4.272

5.  The mouse immunoglobulin heavy-chain gene enhancer contains sequences that inhibit transcription in vitro in HeLa cell extracts.

Authors:  J P Dougherty; P Augereau; P Chambon
Journal:  Mol Cell Biol       Date:  1986-11       Impact factor: 4.272

6.  In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer.

Authors:  B P Tsao; X F Wang; C L Peterson; K Calame
Journal:  Nucleic Acids Res       Date:  1988-04-25       Impact factor: 16.971

7.  Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer.

Authors:  J Weinberger; P S Jat; P A Sharp
Journal:  Mol Cell Biol       Date:  1988-02       Impact factor: 4.272

Review 8.  Regulation of early adenovirus gene expression.

Authors:  J R Nevins
Journal:  Microbiol Rev       Date:  1987-12

9.  Use of recombinant retroviruses to study the regulation of integrated adenovirus early promoters.

Authors:  R K Strair; J S Miller; B E Roberts
Journal:  J Virol       Date:  1988-06       Impact factor: 5.103

10.  Nuclear factors binding to the human immunoglobulin heavy-chain gene enhancer.

Authors:  H Maeda; K Araki; D Kitamura; J Wang; T Watanabe
Journal:  Nucleic Acids Res       Date:  1987-04-10       Impact factor: 16.971
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