Literature DB >> 6512493

Induction of immunoglobulin gene expression in mouse fibroblasts by cycloheximide treatment.

T Ishihara, A Kudo, T Watanabe.   

Abstract

A complete set of a rearranged human gamma 1-heavy chain gene, HIG1, was cloned from human plasma cell leukemia line, ARH-77, and transferred into mouse cells. It was strongly expressed in mouse myeloma cells but not in mouse L cells, indicating that immunoglobulin gene expression is not species-specific but cell-specific. However, a remarkable production of human gamma 1 chain was induced in mouse L cells containing HIG1 gene when the cells were treated with cycloheximide for a short period. The role of a labile repressor molecule in the expression of the immunoglobulin gene is proposed.

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Year:  1984        PMID： 6512493      PMCID： PMC2187535          DOI： 10.1084/jem.160.6.1937

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  22 in total

1.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

2.  Fusion of T and B cells.

Authors:  G Köhler; T Pearson; C Milstein
Journal:  Somatic Cell Genet       Date:  1977-05

3.  Inhibition of protein synthesis stimulates the transcription of human beta-interferon genes in Chinese hamster ovary cells.

Authors:  G M Ringold; B Dieckmann; J L Vannice; M Trahey; F McCormick
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

4.  High frequency of gene transfer after fusion between bacteria and eukaryotic cells.

Authors:  M Rassoulzadegan; B Binetruy; F Cuzin
Journal:  Nature       Date:  1982-01-21       Impact factor: 49.962

5.  Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways.

Authors:  P Early; J Rogers; M Davis; K Calame; M Bond; R Wall; L Hood
Journal:  Cell       Date:  1980-06       Impact factor: 41.582

6.  Purification to apparent homogeneity of murine interleukin 1.

Authors:  S B Mizel; D Mizel
Journal:  J Immunol       Date:  1981-03       Impact factor: 5.422

7.  Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

Authors:  R C Mulligan; P Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

8.  Immunoglobulin gene expression in transformed lymphoid cells.

Authors:  V T Oi; S L Morrison; L A Herzenberg; P Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

9.  Cycloheximide induces expression of the human interferon beta 1 gene in mouse cells transformed by bovine papillomavirus-interferon beta 1 recombinants.

Authors:  L Maroteaux; L Chen; S Mitrani-Rosenbaum; P M Howley; M Revel
Journal:  J Virol       Date:  1983-07       Impact factor: 5.103

10.  Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

Authors:  M S Neuberger
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  23 in total

1.  Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity.

Authors:  T Kadesch; P Zervos; D Ruezinsky
Journal:  Nucleic Acids Res       Date:  1986-10-24       Impact factor: 16.971

2.  Posttranscriptional control of human gamma interferon gene expression in transfected mouse fibroblasts.

Authors:  H A Young; L Varesio; P Hwu
Journal:  Mol Cell Biol       Date:  1986-06       Impact factor: 4.272

3.  Positive and negative regulation of immunoglobulin gene expression by a novel B-cell-specific enhancer element.

Authors:  J Wang; M Oketani; T Watanabe
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

4.  Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

Authors:  J L Imler; C Lemaire; C Wasylyk; B Wasylyk
Journal:  Mol Cell Biol       Date:  1987-07       Impact factor: 4.272

5.  A labile inhibitor blocks immunoglobulin kappa-light-chain-gene transcription in a pre-B leukemic cell line.

Authors:  R Wall; M Briskin; C Carter; H Govan; A Taylor; P Kincade
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

6.  The mouse immunoglobulin heavy-chain gene enhancer contains sequences that inhibit transcription in vitro in HeLa cell extracts.

Authors:  J P Dougherty; P Augereau; P Chambon
Journal:  Mol Cell Biol       Date:  1986-11       Impact factor: 4.272

7.  Cell-type-specific and regulated expression of a human gamma 1 heavy-chain immunoglobulin gene in transgenic mice.

Authors:  K Yamamura; A Kudo; T Ebihara; K Kamino; K Araki; Y Kumahara; T Watanabe
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

8.  Transcriptional and posttranscriptional control of c-fos gene expression in human monocytes.

Authors:  E Sariban; R Luebbers; D Kufe
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

9.  The immunoglobulin heavy chain enhancer is stimulated by the adenovirus type 2 E1A products in mouse fibroblasts.

Authors:  E Borrelli; R Hen; C Wasylyk; B Wasylyk; P Chambon
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

10.  Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line.

Authors:  D M Zaller; H Yu; L A Eckhardt
Journal:  Mol Cell Biol       Date:  1988-05       Impact factor: 4.272
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