Literature DB >> 3039350

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

J L Imler, C Lemaire, C Wasylyk, B Wasylyk.   

Abstract

We have identified in and around the immunoglobulin heavy-chain enhancer two apparently distinct negative regulatory elements which repress immunoglobulin H enhancer, simian virus 40 enhancer, and heterologous promoter activity in fibroblasts but not in myeloma cells. We propose that in nonlymphoid cells, negative regulatory elements prevent activation of the immunoglobulin H enhancer by ubiquitous stimulatory trans-acting factors.

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Year:  1987        PMID： 3039350      PMCID： PMC365391          DOI： 10.1128/mcb.7.7.2558-2567.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  50 in total

1.  Extinction of expression of immunoglobulin genes in myeloma X fibroblast somatic cell hybrids.

Authors:  A Greenberg; R Ber; Z Kra-Oz; R Laskov
Journal:  Mol Cell Biol       Date:  1987-02       Impact factor: 4.272

2.  Phenotype and hybrids between lymphoid cells and rat hepatoma cells.

Authors:  S Junker
Journal:  Exp Cell Res       Date:  1982-05       Impact factor: 3.905

3.  A new dominant hybrid selective marker for higher eukaryotic cells.

Authors:  F Colbère-Garapin; F Horodniceanu; P Kourilsky; A C Garapin
Journal:  J Mol Biol       Date:  1981-07-25       Impact factor: 5.469

4.  A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

Authors:  S D Gillies; S L Morrison; V T Oi; S Tonegawa
Journal:  Cell       Date:  1983-07       Impact factor: 41.582

5.  A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.

Authors:  J Banerji; L Olson; W Schaffner
Journal:  Cell       Date:  1983-07       Impact factor: 41.582

6.  Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit beta-globin gene in mouse 3T6 cells.

Authors:  P Dierks; A van Ooyen; M D Cochran; C Dobkin; J Reiser; C Weissmann
Journal:  Cell       Date:  1983-03       Impact factor: 41.582

7.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

8.  Expression of immunoglobulin synthesis in human myeloma x non-lymphoid cell heterokaryons: evidence for negative control.

Authors:  J Zeuthen; S Stenman; H A Fabricius; K Nilsson
Journal:  Cell Differ       Date:  1976-03

9.  Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.

Authors:  M Mercola; X F Wang; J Olsen; K Calame
Journal:  Science       Date:  1983-08-12       Impact factor: 47.728

10.  Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

Authors:  M S Neuberger
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  47 in total

1.  Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination.

Authors:  X P Zhong; J Carabaña; M S Krangel
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

2.  The SV40 early transcriptional regulatory element is unable to direct gene expression in pituitary GH-3 cells.

Authors:  T A Coleman; Y T Hou; J J Kopchick
Journal:  Gene Expr       Date:  1992

3.  The transcriptional tissue specificity of the human pro alpha 1 (I) collagen gene is determined by a negative cis-regulatory element in the promoter.

Authors:  C P Simkevich; J P Thompson; H Poppleton; R Raghow
Journal:  Biochem J       Date:  1992-08-15       Impact factor: 3.857

4.  Octamer-binding proteins in diverse hemopoietic cells.

Authors:  P N Cockerill; S P Klinken
Journal:  Mol Cell Biol       Date:  1990-03       Impact factor: 4.272

5.  Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2.

Authors:  B K Yoza; R G Roeder
Journal:  Mol Cell Biol       Date:  1990-05       Impact factor: 4.272

6.  Mutagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cells.

Authors:  D T Crowe; M J Tsai
Journal:  Mol Cell Biol       Date:  1989-04       Impact factor: 4.272

7.  Identification of a matrix-associated region 5' of an immunoglobulin heavy chain variable region gene.

Authors:  C F Webb; C Das; K L Eneff; P W Tucker
Journal:  Mol Cell Biol       Date:  1991-10       Impact factor: 4.272

8.  Silencing of the expression of the immunoglobulin kappa gene in non-B cells.

Authors:  J W Pierce; A M Gifford; D Baltimore
Journal:  Mol Cell Biol       Date:  1991-03       Impact factor: 4.272

9.  The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein.

Authors:  R S Herbst; E M Boczko; J E Darnell; L E Babiss
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

10.  A negative regulatory element in the promoter of the human alpha 1-antitrypsin gene.

Authors:  V De Simone; R Cortese
Journal:  Nucleic Acids Res       Date:  1989-11-25       Impact factor: 16.971
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