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Literature DB >> 3025633

The mouse immunoglobulin heavy-chain gene enhancer contains sequences that inhibit transcription in vitro in HeLa cell extracts.

Abstract

The effect of the cell-specific mouse immunoglobulin heavy-chain gene (IgH) enhancer on transcription from heterologous promoter elements was studied in vitro with a HeLa whole-cell extract. No stimulation of transcription could be seen under conditions in which an activation was observed with the simian virus 40 enhancer. We found, however, that a specific segment of the IgH enhancer region contains sequences which inhibit transcription in vitro.

Entities: Gene Species

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Year: 1986 PMID： 3025633 PMCID： PMC367181 DOI： 10.1128/mcb.6.11.4117-4121.1986

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

20 in total

1. The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants.

Authors: P Moreau; R Hen; B Wasylyk; R Everett; M P Gaub; P Chambon
Journal: Nucleic Acids Res Date: 1981-11-25 Impact factor: 16.971

2. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

Authors: S D Gillies; S L Morrison; V T Oi; S Tonegawa
Journal: Cell Date: 1983-07 Impact factor: 41.582

3. Immunoglobulin gene transcription is activated by downstream sequence elements.

Authors: C Queen; D Baltimore
Journal: Cell Date: 1983-07 Impact factor: 41.582

4. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.

Authors: J Banerji; L Olson; W Schaffner
Journal: Cell Date: 1983-07 Impact factor: 41.582

5. The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements.

Authors: B Wasylyk; C Wasylyk; P Augereau; P Chambon
Journal: Cell Date: 1983-02 Impact factor: 41.582

3. One cell-specific and three ubiquitous nuclear proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer.

Authors: J H Xiao; I Davidson; D Ferrandon; R Rosales; M Vigneron; M Macchi; F Ruffenach; P Chambon
Journal: EMBO J Date: 1987-10 Impact factor: 11.598

3 in total

The mouse immunoglobulin heavy-chain gene enhancer contains sequences that inhibit transcription in vitro in HeLa cell extracts.

1. The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants.

2. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

3. Immunoglobulin gene transcription is activated by downstream sequence elements.

4. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.

5. The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements.

6. A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene.

Review 7. Somatic generation of antibody diversity.

Review 8. Viral and cellular transcription enhancers.

9. DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.

10. Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1. Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

2. In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer.

3. One cell-specific and three ubiquitous nuclear proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer.