Literature DB >> 29260484

Breast Cancer Genetics Knowledge and Testing Intentions among Nigerian Professional Women.

Samuel O Ngene1, Babatunde Adedokun2, Prisca Adejumo3, Olufunmilayo Olopade4.   

Abstract

Genetic testing services for breast cancer are well established in developed countries compared to African populations that bear a disproportionate burden of breast cancer (BC). The objective of this study is to examine the knowledge of professional Nigerian women about BC genetics and their intentions to utilize genetic testing services when it is made available in Nigeria. In this study, 165 lecturers and 189 bankers were recruited and studied using a validated self-administered questionnaire. The respondents' mean age was 34.9 years (SD = 10.9), 6.5% had family history of BC, and 84.7% had limited knowledge of breast cancer genetics. The proportion of women with genetic testing intentions for breast cancer was 87.3%. Health care access (OR = 2.35, 95% CI, 1.07-5.13), religion (OR = 3.51, 95% CI, 1.03-11.92), and perceived personal risk if a close relative had breast cancer (OR = 2.31, 95% CI, 1.05-5.08) independently predicted testing intentions. The genetic testing intentions for BC were high despite limited knowledge about breast cancer genetics. Promotion of BC genetics education as well as efforts to make BC genetic testing services available in Nigeria at reduced cost remains essential.

Entities:  

Keywords:  BRCA 1; BRCA 2; Breast cancer; Genetic testing; Nigeria; Professional women; Willingness

Mesh:

Year:  2017        PMID: 29260484     DOI: 10.1007/s10897-017-0194-4

Source DB:  PubMed          Journal:  J Genet Couns        ISSN: 1059-7700            Impact factor:   2.537


  54 in total

1.  Complete allelic analysis of BRCA1 and BRCA2 variants in young Nigerian breast cancer patients.

Authors:  J D Fackenthal; L Sveen; Q Gao; E K Kohlmeir; C Adebamowo; T O Ogundiran; A A Adenipekun; R Oyesegun; O Campbell; C Rotimi; E E U Akang; S Das; O I Olopade
Journal:  J Med Genet       Date:  2005-03       Impact factor: 6.318

2.  Women's interest in genetic testing for breast cancer risk: the influence of sociodemographics and knowledge.

Authors:  Joan L Bottorff; Pamela A Ratner; Lynda G Balneaves; Chris G Richardson; Mary McCullum; Tom Hack; Karen Chalmers; Jane Buxton
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2002-01       Impact factor: 4.254

3.  Direct-to-consumer genetic testing: good, bad or benign?

Authors:  T Caulfield; N M Ries; P N Ray; C Shuman; B Wilson
Journal:  Clin Genet       Date:  2009-11-21       Impact factor: 4.438

4.  Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE.

Authors:  Nasim Mavaddat; Susan Peock; Debra Frost; Steve Ellis; Radka Platte; Elena Fineberg; D Gareth Evans; Louise Izatt; Rosalind A Eeles; Julian Adlard; Rosemarie Davidson; Diana Eccles; Trevor Cole; Jackie Cook; Carole Brewer; Marc Tischkowitz; Fiona Douglas; Shirley Hodgson; Lisa Walker; Mary E Porteous; Patrick J Morrison; Lucy E Side; M John Kennedy; Catherine Houghton; Alan Donaldson; Mark T Rogers; Huw Dorkins; Zosia Miedzybrodzka; Helen Gregory; Jacqueline Eason; Julian Barwell; Emma McCann; Alex Murray; Antonis C Antoniou; Douglas F Easton
Journal:  J Natl Cancer Inst       Date:  2013-04-29       Impact factor: 13.506

5.  Awareness and practice of breast screening and its impact on early detection and presentation among breast cancer patients attending a clinic in Lagos, Nigeria.

Authors:  T O Olajide; A O Ugburo; M O Habeebu; A O Lawal; M O Afolayan; M O Mofikoya
Journal:  Niger J Clin Pract       Date:  2014 Nov-Dec       Impact factor: 0.968

6.  Controlled trial of pretest education approaches to enhance informed decision-making for BRCA1 gene testing.

Authors:  C Lerman; B Biesecker; J L Benkendorf; J Kerner; A Gomez-Caminero; C Hughes; M M Reed
Journal:  J Natl Cancer Inst       Date:  1997-01-15       Impact factor: 13.506

7.  Public interest in genetic testing for susceptibility to heart disease and cancer: a population-based survey in the UK.

Authors:  Saskia C Sanderson; Jane Wardle; Martin J Jarvis; Steve E Humphries
Journal:  Prev Med       Date:  2004-09       Impact factor: 4.018

8.  Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force recommendation statement.

Authors:  Virginia A Moyer
Journal:  Ann Intern Med       Date:  2014-02-18       Impact factor: 25.391

9.  Attitude towards genetic testing for breast cancer susceptibility: a comparison of affected and unaffected women.

Authors:  M Bruno; M Digennaro; S Tommasi; B Stea; T Danese; F Schittulli; A Paradiso
Journal:  Eur J Cancer Care (Engl)       Date:  2009-11-13       Impact factor: 2.520

10.  Gene-panel sequencing and the prediction of breast-cancer risk.

Authors:  Douglas F Easton; Paul D P Pharoah; Antonis C Antoniou; Marc Tischkowitz; Sean V Tavtigian; Katherine L Nathanson; Peter Devilee; Alfons Meindl; Fergus J Couch; Melissa Southey; David E Goldgar; D Gareth R Evans; Georgia Chenevix-Trench; Nazneen Rahman; Mark Robson; Susan M Domchek; William D Foulkes
Journal:  N Engl J Med       Date:  2015-05-27       Impact factor: 91.245

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  2 in total

Review 1.  Familial/inherited cancer syndrome: a focus on the highly consanguineous Arab population.

Authors:  Fawz S AlHarthi; Alya Qari; Alaa Edress; Malak Abedalthagafi
Journal:  NPJ Genom Med       Date:  2020-02-03       Impact factor: 8.617

Review 2.  Familial/inherited cancer syndrome: a focus on the highly consanguineous Arab population.

Authors:  Fawz S AlHarthi; Alya Qari; Alaa Edress; Malak Abedalthagafi
Journal:  NPJ Genom Med       Date:  2020-02-03       Impact factor: 8.617

  2 in total

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