Literature DB >> 28817228

Isolation of the New Antiplasmodial Butanolide, Malleastrumolide A, from Malleastrum sp. (Meliaceae) from Madagascar.

Yongle Du1, Alexander K Abedi1, Ana Lisa Valenciano2, Maria L Fernández-Murga3, Maria B Cassera2,3, Vincent E Rasamison4, Wendy L Applequist5, James S Miller5, David G I Kingston1.   

Abstract

An extract of Malleastrum sp. (Meliaceae) collected in Madagascar by the Madagascar International Cooperative Biodiversity Group was found to have antimalarial activity, with an IC50 value between 2.5 and 5 μg ml-1 . After purification by liquid-liquid partition, chromatography on a Diaion open column, C18 SPE and C18 reversed phase HPLC, the new butanolide, malleastrumolide A, was isolated. The structure of malleastrumolide A was determined by mass spectrometry, NMR, and ECD. The double bond position was determined by cross-metathesis and mass spectrometry. The compound has antiproliferative activity against the A2780 ovarian cancer cell line with an IC50 value of 17.4 μm and antiplasmodial activity against the drug-resistant Dd2 strain of Plasmodium falciparum with an IC50 value of 2.74 μm.
© 2017 Wiley-VHCA AG, Zurich, Switzerland.

Entities:  

Keywords:  zzm321990Malleastrumzzm321990; Antiplasmodial activity; Butanolide; Madagascar; Meliaceae

Mesh：

Substances：

Year:  2017        PMID： 28817228      PMCID： PMC5739943          DOI： 10.1002/cbdv.201700331

Source DB:  PubMed          Journal:  Chem Biodivers        ISSN： 1612-1872            Impact factor:   2.408


  15 in total

1.  Simple determination of double-bond positions in long-chain olefins by cross-metathesis.

Authors:  Yongseok Kwon; Seonwoo Lee; Dong-Chan Oh; Sanghee Kim
Journal:  Angew Chem Int Ed Engl       Date:  2011-06-24       Impact factor: 15.336

Review 2.  Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.

Authors:  Richard T Eastman; David A Fidock
Journal:  Nat Rev Microbiol       Date:  2009-11-02       Impact factor: 60.633

Review 3.  Artemisinin and its derivatives: an important new class of antimalarial agents.

Authors:  G A Balint
Journal:  Pharmacol Ther       Date:  2001 May-Jun       Impact factor: 12.310

4.  Four diphenylpropanes and a cycloheptadibenzofuran from Bussea sakalava from the Madagascar dry forest.

Authors:  Ende Pan; Liva Harinantenaina; Peggy J Brodie; James S Miller; Martin W Callmander; Stephan Rakotonandrasana; Etienne Rakotobe; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2010-10-13       Impact factor: 4.050

5.  Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy.

Authors:  Tyler N Bennett; Michelle Paguio; Bojana Gligorijevic; Clement Seudieu; Andrew D Kosar; Eugene Davidson; Paul D Roepe
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

6.  Antiproliferative limonoids of a Malleastrum sp. from the Madagascar rainforest.

Authors:  Brian T Murphy; Peggie Brodie; Carla Slebodnick; James S Miller; Chris Birkinshaw; Lucien M Randrianjanaka; Rabodo Andriantsiferana; Vincent E Rasamison; Karen TenDyke; Edward M Suh; David G I Kingston
Journal:  J Nat Prod       Date:  2008-01-05       Impact factor: 4.050

7.  Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.

Authors:  K G Louie; B C Behrens; T J Kinsella; T C Hamilton; K R Grotzinger; W M McKoy; M A Winker; R F Ozols
Journal:  Cancer Res       Date:  1985-05       Impact factor: 12.701

8.  Spread of artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Elizabeth A Ashley; Mehul Dhorda; Rick M Fairhurst; Chanaki Amaratunga; Parath Lim; Seila Suon; Sokunthea Sreng; Jennifer M Anderson; Sivanna Mao; Baramey Sam; Chantha Sopha; Char Meng Chuor; Chea Nguon; Siv Sovannaroth; Sasithon Pukrittayakamee; Podjanee Jittamala; Kesinee Chotivanich; Kitipumi Chutasmit; Chaiyaporn Suchatsoonthorn; Ratchadaporn Runcharoen; Tran Tinh Hien; Nguyen Thanh Thuy-Nhien; Ngo Viet Thanh; Nguyen Hoan Phu; Ye Htut; Kay-Thwe Han; Kyin Hla Aye; Olugbenga A Mokuolu; Rasaq R Olaosebikan; Olaleke O Folaranmi; Mayfong Mayxay; Maniphone Khanthavong; Bouasy Hongvanthong; Paul N Newton; Marie A Onyamboko; Caterina I Fanello; Antoinette K Tshefu; Neelima Mishra; Neena Valecha; Aung Pyae Phyo; Francois Nosten; Poravuth Yi; Rupam Tripura; Steffen Borrmann; Mahfudh Bashraheil; Judy Peshu; M Abul Faiz; Aniruddha Ghose; M Amir Hossain; Rasheda Samad; M Ridwanur Rahman; M Mahtabuddin Hasan; Akhterul Islam; Olivo Miotto; Roberto Amato; Bronwyn MacInnis; Jim Stalker; Dominic P Kwiatkowski; Zbynek Bozdech; Atthanee Jeeyapant; Phaik Yeong Cheah; Tharisara Sakulthaew; Jeremy Chalk; Benjamas Intharabut; Kamolrat Silamut; Sue J Lee; Benchawan Vihokhern; Chanon Kunasol; Mallika Imwong; Joel Tarning; Walter J Taylor; Shunmay Yeung; Charles J Woodrow; Jennifer A Flegg; Debashish Das; Jeffery Smith; Meera Venkatesan; Christopher V Plowe; Kasia Stepniewska; Philippe J Guerin; Arjen M Dondorp; Nicholas P Day; Nicholas J White
Journal:  N Engl J Med       Date:  2014-07-31       Impact factor: 91.245

9.  Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest.

Authors:  Noureddine Allouche; Cécile Apel; Marie-Thérèse Martin; Vincent Dumontet; Françoise Guéritte; Marc Litaudon
Journal:  Phytochemistry       Date:  2009-02-27       Impact factor: 4.072

Review 10.  Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products.

Authors:  Ronan Batista; Ademir de Jesus Silva; Alaíde Braga de Oliveira
Journal:  Molecules       Date:  2009-08-13       Impact factor: 4.411
View more
  2 in total

Review 1.  Antiplasmodial natural products: an update.

Authors:  Nasir Tajuddeen; Fanie R Van Heerden
Journal:  Malar J       Date:  2019-12-05       Impact factor: 2.979

2.  Phytochemical Investigation and Anti-Inflammatory Activity of the Leaves of Machilus japonica var. kusanoi.

Authors:  Shiou-Ling Li; Ho-Cheng Wu; Tsong-Long Hwang; Chu-Hung Lin; Shuen-Shin Yang; Hsun-Shuo Chang
Journal:  Molecules       Date:  2020-09-10       Impact factor: 4.411
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.