Literature DB >> 19251287

Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest.

Noureddine Allouche1, Cécile Apel, Marie-Thérèse Martin, Vincent Dumontet, Françoise Guéritte, Marc Litaudon.   

Abstract

One secobutanolide, two butanolides and six drimane sesquiterpenoids were isolated from the bark and leaves of Zygogynum pancheri and Zygogynum acsmithii (Winteraceae) along with six known drimanes, isodrimanial, 1beta-O-p-methoxy-E-cinnamoyl-bemadienolide, 7-ketoisodrimenin, drimenin, polygodial and 1beta-E-cinnamoyl-6alpha-hydroxypolygodial. Their structures were elucidated through analysis of spectroscopic data. Drimane sesquiterpenoids with a dialdehyde function exhibited significant inhibitory activities in the in vitro cytotoxic assays against KB, HL60 and HCT116 cancer cell lines.

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Year:  2009        PMID： 19251287     DOI： 10.1016/j.phytochem.2009.01.012

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  7 in total

1.  Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells.

Authors:  Ramesh Dasari; Annelise De Carvalho; Derek C Medellin; Kelsey N Middleton; Frédéric Hague; Marie N M Volmar; Liliya V Frolova; Mateus F Rossato; Jorge J De La Chapa; Nicholas F Dybdal-Hargreaves; Akshita Pillai; Véronique Mathieu; Snezna Rogelj; Cara B Gonzales; João B Calixto; Antonio Evidente; Mathieu Gautier; Gnanasekar Munirathinam; Rainer Glass; Patricia Burth; Stephen C Pelly; Willem A L van Otterlo; Robert Kiss; Alexander Kornienko
Journal:  ChemMedChem       Date:  2015-10-05       Impact factor: 3.466

2.  Growth inhibition of human colon carcinoma cells by sesquiterpenoids and tetralones of Zygogynum calothyrsum.

Authors:  Krishna P Devkota; David Covell; Tanya Ransom; James B McMahon; John A Beutler
Journal:  J Nat Prod       Date:  2013-03-21       Impact factor: 4.050

3.  Isolation of the New Antiplasmodial Butanolide, Malleastrumolide A, from Malleastrum sp. (Meliaceae) from Madagascar.

Authors:  Yongle Du; Alexander K Abedi; Ana Lisa Valenciano; Maria L Fernández-Murga; Maria B Cassera; Vincent E Rasamison; Wendy L Applequist; James S Miller; David G I Kingston
Journal:  Chem Biodivers       Date:  2017-12-15       Impact factor: 2.408

Review 4.  Anticancer Activity of Natural and Semi-Synthetic Drimane and Coloratane Sesquiterpenoids.

Authors:  Lorenz Beckmann; Uta Sandy Tretbar; Reni Kitte; Maik Tretbar
Journal:  Molecules       Date:  2022-04-13       Impact factor: 4.927

5.  Further drimane sesquiterpenes from Drimys brasiliensis stem barks with cytotoxic potential.

Authors:  Eduarda Fratoni; Vanessa Duarte Claudino; Rosendo Augusto Yunes; Gilberto C Franchi; Alexandre E Nowill; Valdir Cechinel Filho; Franco Delle Monache; Angela Malheiros
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-04-19       Impact factor: 3.000

6.  Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines.

Authors:  Ramesh Dasari; Annelise De Carvalho; Derek C Medellin; Kelsey N Middleton; Frédéric Hague; Marie N M Volmar; Liliya V Frolova; Mateus F Rossato; Jorge J De La Chapa; Nicholas F Dybdal-Hargreaves; Akshita Pillai; Roland E Kälin; Véronique Mathieu; Snezna Rogelj; Cara B Gonzales; João B Calixto; Antonio Evidente; Mathieu Gautier; Gnanasekar Munirathinam; Rainer Glass; Patricia Burth; Stephen C Pelly; Willem A L van Otterlo; Robert Kiss; Alexander Kornienko
Journal:  Eur J Med Chem       Date:  2015-08-29       Impact factor: 6.514

7.  Ugandenial A, a new drimane-type sesquiterpenoid from Warburgia ugandensis.

Authors:  Min Xu; Marc Litaudon; Sabrina Krief; Marie-Thérèse Martin; John Kasenene; Bernard Kiremire; Vincent Dumontet; Françoise Guéritte
Journal:  Molecules       Date:  2009-09-28       Impact factor: 4.411
  7 in total

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