Nasir Tajuddeen1, Fanie R Van Heerden2. 1. School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg, 3209, South Africa. 2. School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg, 3209, South Africa. vanheerdenf@ukzn.ac.za.
Abstract
BACKGROUND: Malaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria incidences was recorded during the last decade due to the availability of effective control interventions, such as the deployment of artemisinin-based combination therapy and insecticide-treated nets. However, according to the World Health Organization, malaria is staging a comeback, in part due to the development of drug resistance. Therefore, there is an urgent need to discover new anti-malarial drugs. This article reviews the literature on natural products with antiplasmodial activity that was reported between 2010 and 2017. METHODS: Relevant literature was sourced by searching the major scientific databases, including Web of Science, ScienceDirect, Scopus, SciFinder, Pubmed, and Google Scholar, using appropriate keyword combinations. RESULTS AND DISCUSSION: A total of 1524 compounds from 397 relevant references, assayed against at least one strain of Plasmodium, were reported in the period under review. Out of these, 39% were described as new natural products, and 29% of the compounds had IC50 ≤ 3.0 µM against at least one strain of Plasmodium. Several of these compounds have the potential to be developed into viable anti-malarial drugs. Also, some of these compounds could play a role in malaria eradication by targeting gametocytes. However, the research into natural products with potential for blocking the transmission of malaria is still in its infancy stage and needs to be vigorously pursued.
BACKGROUND: <span class="Disease">Malaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria incidences was recorded during the last decade due to the availability of effective control interventions, such as the deployment of artemisinin-based combination therapy and insecticide-treated nets. However, according to the World Health Organization, malaria is staging a comeback, in part due to the development of drug resistance. Therefore, there is an urgent need to discover new anti-malarial drugs. This article reviews the literature on natural products with antiplasmodial activity that was reported between 2010 and 2017. METHODS: Relevant literature was sourced by searching the major scientific databases, including Web of Science, ScienceDirect, Scopus, SciFinder, Pubmed, and Google Scholar, using appropriate keyword combinations. RESULTS AND DISCUSSION: A total of 1524 compounds from 397 relevant references, assayed against at least one strain of Plasmodium, were reported in the period under review. Out of these, 39% were described as new natural products, and 29% of the compounds had IC50 ≤ 3.0 µM against at least one strain of Plasmodium. Several of these compounds have the potential to be developed into viable anti-malarial drugs. Also, some of these compounds could play a role in malaria eradication by targeting gametocytes. However, the research into natural products with potential for blocking the transmission of malaria is still in its infancy stage and needs to be vigorously pursued.
Authors: Minkyun Na; Yuanqing Ding; Bin Wang; Babu L Tekwani; Raymond F Schinazi; Scott Franzblau; Michelle Kelly; Robert Stone; Xing-Cong Li; Daneel Ferreira; Mark T Hamann Journal: J Nat Prod Date: 2010-03-26 Impact factor: 4.050
Authors: Emmanuelle Gros; Ali Al-Mourabit; Marie-Thérèse Martin; Jonathan Sorres; Jean Vacelet; Michel Frederich; Maurice Aknin; Yoel Kashman; Anne Gauvin-Bialecki Journal: J Nat Prod Date: 2014-03-06 Impact factor: 4.050
Authors: Andrew M White; Kathy Dao; Darius Vrubliauskas; Zef A Könst; Gregory K Pierens; Attila Mándi; Katherine T Andrews; Tina S Skinner-Adams; Mary E Clarke; Patrick T Narbutas; Desmond C-M Sim; Karen L Cheney; Tibor Kurtán; Mary J Garson; Christopher D Vanderwal Journal: J Org Chem Date: 2017-11-28 Impact factor: 4.354
Authors: Raceline G Kamkumo; Alvine M Ngoutane; Lauve R Y Tchokouaha; Patrick V T Fokou; Eugénie A K Madiesse; Jennifer Legac; Jean J B Kezetas; Bruno N Lenta; Fabrice F Boyom; Theophile Dimo; Wilfred F Mbacham; Jiri Gut; Philip J Rosenthal Journal: Malar J Date: 2012-11-21 Impact factor: 2.979
Authors: Beatrice N Irungu; Nicholas Adipo; Jennifer A Orwa; Francis Kimani; Matthias Heydenreich; Jacob O Midiwo; Per Martin Björemark; Mikael Håkansson; Abiy Yenesew; Máté Erdélyi Journal: J Ethnopharmacol Date: 2015-08-28 Impact factor: 4.360
Authors: Selorme Adukpo; Doris Elewosi; Richard Harry Asmah; Alexander K Nyarko; Patrick Kwaku Ekpe; Dominic Adotei Edoh; Michael Fokua Ofori Journal: Evid Based Complement Alternat Med Date: 2020-09-23 Impact factor: 2.629
Authors: Susiany P Lopes; Lina M Yepes; Yunierkis Pérez-Castillo; Sara M Robledo; Damião P de Sousa Journal: Molecules Date: 2020-07-11 Impact factor: 4.411
Authors: Boris D Bekono; Fidele Ntie-Kang; Pascal Amoa Onguéné; Lydia L Lifongo; Wolfgang Sippl; Karin Fester; Luc C O Owono Journal: Malar J Date: 2020-05-18 Impact factor: 2.979
Authors: James Knockleby; Bruno Pradines; Mathieu Gendrot; Joel Mosnier; Thanh Tam Nguyen; Thi Thuy Trinh; Hoyun Lee; Phuong Mai Le Journal: Molecules Date: 2020-08-18 Impact factor: 4.411