Literature DB >> 15105139

Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy.

Tyler N Bennett1, Michelle Paguio, Bojana Gligorijevic, Clement Seudieu, Andrew D Kosar, Eugene Davidson, Paul D Roepe.   

Abstract

We report on the development of a new SYBR Green I-based plate assay for analyzing the activities of antimalarial drugs against intraerythrocytic Plasmodium falciparum. This assay is considerably faster, less labor-intensive, and less expensive than conventional radiotracer (e.g., [3H]hypoxanthine and [3H]ethanolamine)-based assays or P. falciparum lactate dehydrogenase activity-based assays. The assay significantly improves the pace at which antimalarial drug discovery efforts may proceed.

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Year:  2004        PMID： 15105139      PMCID： PMC400551          DOI： 10.1128/AAC.48.5.1807-1810.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

Review 1.  Medical need, scientific opportunity and the drive for antimalarial drugs.

Authors:  Robert G Ridley
Journal:  Nature       Date:  2002-02-07       Impact factor: 49.962

2.  A sensitive two-color electrophoretic mobility shift assay for detecting both nucleic acids and protein in gels.

Authors:  Debra Jing; Jakyoung Agnew; Wayne F Patton; Jill Hendrickson; Joseph M Beechem
Journal:  Proteomics       Date:  2003-07       Impact factor: 3.984

3.  Rapid staining and enumeration of small numbers of total bacteria in water by solid-phase laser cytometry.

Authors:  Susan C Broadaway; Stephanie A Barton; Barry H Pyle
Journal:  Appl Environ Microbiol       Date:  2003-07       Impact factor: 4.792

4.  Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa.

Authors:  X Su; L A Kirkman; H Fujioka; T E Wellems
Journal:  Cell       Date:  1997-11-28       Impact factor: 41.582

5.  Detection and genotyping by real-time PCR/RFLP analyses of Giardia duodenalis from human faeces.

Authors:  Corinne F L Amar; Paul H Dear; Jim McLauchlin
Journal:  J Med Microbiol       Date:  2003-08       Impact factor: 2.472

6.  Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues.

Authors:  George M Yousef; Carsten Stephan; Andreas Scorilas; Mohamed Abd Ellatif; Klaus Jung; Glen Kristiansen; Monika Jung; Mary-Ellen Polymeris; Eleftherios P Diamandis
Journal:  Prostate       Date:  2003-09-01       Impact factor: 4.104

7.  Development of a rapid, small-scale DNA repair assay for use on clinical samples.

Authors:  Christine P Diggle; Johanne Bentley; Anne E Kiltie
Journal:  Nucleic Acids Res       Date:  2003-08-01       Impact factor: 16.971

8.  Real-time PCR detection of Brucella abortus: a comparative study of SYBR green I, 5'-exonuclease, and hybridization probe assays.

Authors:  D T Newby; T L Hadfield; F F Roberto
Journal:  Appl Environ Microbiol       Date:  2003-08       Impact factor: 4.792
  8 in total
  135 in total

1.  Automated high-throughput system to fractionate plant natural products for drug discovery.

Authors:  Ying Tu; Cynthia Jeffries; Hong Ruan; Cynthia Nelson; David Smithson; Anang A Shelat; Kristin M Brown; Xing-Cong Li; John P Hester; Troy Smillie; Ikhlas A Khan; Larry Walker; Kip Guy; Bing Yan
Journal:  J Nat Prod       Date:  2010-04-23       Impact factor: 4.050

2.  Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening.

Authors:  Jacob D Johnson; Richard A Dennull; Lucia Gerena; Miriam Lopez-Sanchez; Norma E Roncal; Norman C Waters
Journal:  Antimicrob Agents Chemother       Date:  2007-03-19       Impact factor: 5.191

3.  Comparison of a SYBR green I-based assay with a histidine-rich protein II enzyme-linked immunosorbent assay for in vitro antimalarial drug efficacy testing and application to clinical isolates.

Authors:  David J Bacon; Christine Latour; Carmen Lucas; Olga Colina; Pascal Ringwald; Stéphane Picot
Journal:  Antimicrob Agents Chemother       Date:  2007-01-12       Impact factor: 5.191

4.  Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas.

Authors:  Kekeli Ekoue-Kovi; Kimberly Yearick; Daniel P Iwaniuk; Jayakumar K Natarajan; John Alumasa; Angel C de Dios; Paul D Roepe; Christian Wolf
Journal:  Bioorg Med Chem       Date:  2008-11-12       Impact factor: 3.641

5.  Plasmodium falciparum: development of a transgenic line for screening antimalarials using firefly luciferase as the reporter.

Authors:  Long Cui; Jun Miao; Jiaxu Wang; Qianjun Li; Liwang Cui
Journal:  Exp Parasitol       Date:  2008-05-29       Impact factor: 2.011

6.  Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure-activity relationships of related compounds.

Authors:  Yumin Dai; Liva Harinantenaina; Jessica D Bowman; Isabel Osorio Da Fonseca; Peggy J Brodie; Michael Goetz; Maria B Cassera; David G I Kingston
Journal:  Bioorg Med Chem       Date:  2013-11-26       Impact factor: 3.641

7.  Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.

Authors:  Amy L Lane; Elizabeth P Stout; Mark E Hay; Anne C Prusak; Kenneth Hardcastle; Craig R Fairchild; Scott G Franzblau; Karine Le Roch; Jacques Prudhomme; William Aalbersberg; Julia Kubanek
Journal:  J Org Chem       Date:  2007-08-23       Impact factor: 4.354

8.  Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.

Authors:  Sreekanth Kokkonda; Xiaoyi Deng; Karen L White; Farah El Mazouni; John White; David M Shackleford; Kasiram Katneni; Francis C K Chiu; Helena Barker; Jenna McLaren; Elly Crighton; Gong Chen; Inigo Angulo-Barturen; Maria Belen Jimenez-Diaz; Santiago Ferrer; Leticia Huertas-Valentin; Maria Santos Martinez-Martinez; Maria Jose Lafuente-Monasterio; Rajesh Chittimalla; Shatrughan P Shahi; Sergio Wittlin; David Waterson; Jeremy N Burrows; Dave Matthews; Diana Tomchick; Pradipsinh K Rathod; Michael J Palmer; Susan A Charman; Margaret A Phillips
Journal:  J Med Chem       Date:  2020-04-16       Impact factor: 7.446

9.  New potently bioactive alkaloids from Crinum erubescens.

Authors:  Christopher C Presley; Priscilla Krai; Seema Dalal; Qingxi Su; Maria Cassera; Michael Goetz; David G I Kingston
Journal:  Bioorg Med Chem       Date:  2016-08-30       Impact factor: 3.641

10.  Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy.

Authors:  Bojana Gligorijevic; Kyle Purdy; David A Elliott; Roland A Cooper; Paul D Roepe
Journal:  Mol Biochem Parasitol       Date:  2008-01-09       Impact factor: 1.759
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