Literature DB >> 2877937

Heterogeneity in the map distance between X-linked agammaglobulinemia and a map of nine RFLP loci.

J Ott, E J Mensink, A Thompson, J D Schot, R K Schuurman.   

Abstract

In nine family pedigrees in which X-linked agammaglobulinemia (XLA) is segregating, a multi-point linkage analysis has been carried out. In each family, the map distance, d, between XLA and a fixed point in a known map of nine RFLP loci on the X chromosome was estimated by calculating the log likelihoods, L(d). Using a new method, the 10-point likelihood was approximated by appropriately combining three 4-point likelihoods. Homogeneity tests (admixture tests) were performed showing clear evidence for heterogeneity of XLA.

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Year:  1986        PMID： 2877937     DOI： 10.1007/bf00282549

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  9 in total

1.  Linkage probability and its approximate confidence interval under possible heterogeneity.

Authors:  J Ott
Journal:  Genet Epidemiol Suppl       Date:  1986

2.  The number of families required to detect or exclude linkage heterogeneity.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1986-08       Impact factor: 11.025

3.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

4.  Report of the Committee on the Genetic Constitution of the X and Y Chromosomes.

Authors:  P N Goodfellow; K E Davies; H H Ropers
Journal:  Cytogenet Cell Genet       Date:  1985

5.  The genetic linkage map of the human X chromosome.

Authors:  D Drayna; R White
Journal:  Science       Date:  1985-11-15       Impact factor: 47.728

6.  Easy calculations of lod scores and genetic risks on small computers.

Authors:  G M Lathrop; J M Lalouel
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

7.  X-linked agammaglobulinemia and the red blood cell determinants Xg and 12E7 are not closely linked.

Authors:  E J Mensink; J D Schot; P Tippett; J Ott; R K Schuurman
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

8.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

9.  Mapping of a gene for X-linked agammaglobulinemia and evidence for genetic heterogeneity.

Authors:  E J Mensink; A Thompson; J D Schot; W M van de Greef; L A Sandkuyl; R K Schuurman
Journal:  Hum Genet       Date:  1986-08       Impact factor: 4.132
  9 in total
  14 in total

Review 1.  Genetics of human X-linked immunodeficiency diseases.

Authors:  R W Hendriks; R K Schuurman
Journal:  Clin Exp Immunol       Date:  1991-08       Impact factor: 4.330

2.  Localization of the Aland Island eye disease locus to the pericentromeric region of the X chromosome by linkage analysis.

Authors:  T Alitalo; T A Kruse; H Forsius; A W Eriksson; A de la Chapelle
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

3.  BTKbase, mutation database for X-linked agammaglobulinemia (XLA)

Authors:  M Vihinen; B H Belohradsky; R N Haire; E Holinski-Feder; S P Kwan; I Lappalainen; H Lehväslaiho; T Lester; A Meindl; H D Ochs; J Ollila; I Vorechovsky; M Weiss; C I Smith
Journal:  Nucleic Acids Res       Date:  1997-01-01       Impact factor: 16.971

4.  Close linkage of probe p212 (DXS178) to X-linked agammaglobulinemia.

Authors:  S Guioli; B Arveiler; B Bardoni; L D Notarangelo; P Panina; M Duse; A Ugazio; I Oberlé; G de Saint Basile; J L Mandel
Journal:  Hum Genet       Date:  1989-12       Impact factor: 4.132

5.  Linkage heterogeneity between X-linked retinitis pigmentosa and a map of 10 RFLP loci.

Authors:  J D Chen; F Halliday; G Keith; L Sheffield; P Dickinson; R Gray; I Constable; M Denton
Journal:  Am J Hum Genet       Date:  1989-09       Impact factor: 11.025

6.  Evidence for male X chromosomal mosaicism in X-linked agammaglobulinemia.

Authors:  R W Hendriks; E J Mensink; M E Kraakman; A Thompson; R K Schuurman
Journal:  Hum Genet       Date:  1989-10       Impact factor: 4.132

7.  Early diagnosis in X-linked agammaglobulinaemia.

Authors:  R K Schuurman; E J Mensink; L A Sandkuyl; E D Post; H van Velzen-Blad
Journal:  Eur J Pediatr       Date:  1988-01       Impact factor: 3.183

8.  X-linked immunodeficiency with hyperimmunoglobulinemia M appears to be linked to the DXS42 restriction fragment length polymorphism locus.

Authors:  E J Mensink; A Thompson; L A Sandkuyl; M E Kraakman; J D Schot; T Espanol; R K Schuurman
Journal:  Hum Genet       Date:  1987-05       Impact factor: 4.132

Review 9.  Diagnosis of genetic disease using recombinant DNA. Supplement.

Authors:  D N Cooper; J Schmidtke
Journal:  Hum Genet       Date:  1987-09       Impact factor: 4.132

10.  Close linkage of random DNA fragments from Xq 21.3-22 to X-linked agammaglobulinaemia (XLA).

Authors:  S Malcolm; G de Saint Basile; B Arveiler; Y L Lau; P Szabo; A Fischer; C Griscelli; M Debre; J L Mandel; R E Callard
Journal:  Hum Genet       Date:  1987-10       Impact factor: 4.132
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