Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 X-linked agammaglobulinemia and the red blood cell determinants Xg and 12E7 are not closely linked.

Literature DB >> 6595200

X-linked agammaglobulinemia and the red blood cell determinants Xg and 12E7 are not closely linked.

E J Mensink, J D Schot, P Tippett, J Ott, R K Schuurman.

Abstract

Studies on the segregation of the red blood cell determinant Xg in 12 families with X-linked inheritance of agammaglobulinemia (XLA) in 3-4 generations suggested linkage of Xg with XLA. One extensive pedigree of a Dutch family with XLA in eight generations was investigated for Xg and the quantitative polymorphism 12E7. LIPED analysis indicated linkage disproven up to 25cM distance within this pedigree. Taken together with data obtained from two other informative XLA pedigrees and with published data, the results indicate no close linkage between XLA and Xg: 12E7, the distance between XLA and Xg being more than 20cM.

Entities: Disease

Mesh：

Substances：

Year: 1984 PMID： 6595200 DOI： 10.1007/bf00292589

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

16 in total

1. A sex-linked blood group.

Authors: J D MANN; A CAHAN; A G GELB; N FISHER; J HAMPER; P TIPPETT; R SANGER; R R RACE
Journal: Lancet Date: 1962-01-06 Impact factor: 79.321

2. Agammaglobulinemia.

Authors: O C BRUTON
Journal: Pediatrics Date: 1952-06 Impact factor: 7.124

3. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors: J Ott
Journal: Am J Hum Genet Date: 1974-09 Impact factor: 11.025

4. Linkage studies in a family with X-linked recessive ichthyosis employing a cloned DNA sequence from the distal short arm of the X chromosome.

Authors: P Wieacker; K E Davies; B Mevorah; H H Ropers
Journal: Hum Genet Date: 1983 Impact factor: 4.132

5. B lymphocyte precursors in human bone marrow: an analysis of normal individuals and patients with antibody-deficiency states.

Authors: E R Pearl; L B Vogler; A J Okos; W M Crist; A R Lawton; M D Cooper
Journal: J Immunol Date: 1978-04 Impact factor: 5.422

6. Linkage relationships between Retinoschisis, Xg, and a cloned DNA sequence from the distal short arm of the X chromosome.

Authors: P Wieacker; T F Wienker; B Dallapiccola; K Bender; K E Davies; H H Ropers
Journal: Hum Genet Date: 1983 Impact factor: 4.132

X-linked agammaglobulinemia and the red blood cell determinants Xg and 12E7 are not closely linked.

1. A sex-linked blood group.

2. Agammaglobulinemia.

3. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

4. Linkage studies in a family with X-linked recessive ichthyosis employing a cloned DNA sequence from the distal short arm of the X chromosome.

5. B lymphocyte precursors in human bone marrow: an analysis of normal individuals and patients with antibody-deficiency states.

6. Linkage relationships between Retinoschisis, Xg, and a cloned DNA sequence from the distal short arm of the X chromosome.

7. Human X chromosome carries quantitative genes for immunoglobulin M.

8. Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome.

9. A human quantitative polymorphism related to Xg blood groups.

10. Immunodeficiency associated with a deletion in the short arm of the X-chromosome.

1. Differential methylation at the 5' and the 3' CCGG sites flanking the X chromosomal hypervariable DXS255 locus.

2. Evidence for male X chromosomal mosaicism in X-linked agammaglobulinemia.

3. Early diagnosis in X-linked agammaglobulinaemia.

4. Heterogeneity in the map distance between X-linked agammaglobulinemia and a map of nine RFLP loci.

5. Mapping of a gene for X-linked agammaglobulinemia and evidence for genetic heterogeneity.