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Literature DB >> 6585139

Easy calculations of lod scores and genetic risks on small computers.

Abstract

A computer program that calculates lod scores and genetic risks for a wide variety of both qualitative and quantitative genetic traits is discussed. An illustration is given of the joint use of a genetic marker, affection status, and quantitative information in counseling situations regarding Duchenne muscular dystrophy.

Entities: Disease

Mesh：

Substances：

Year: 1984 PMID： 6585139 PMCID： PMC1684427

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

8 in total

1. Extensions to pedigree analysis I. Likehood calculations for simple and complex pedigrees.

Authors: K Lange; R C Elston
Journal: Hum Hered Date: 1975 Impact factor: 0.444

2. Sequential tests for the detection of linkage.

Authors: N E MORTON
Journal: Am J Hum Genet Date: 1955-09 Impact factor: 11.025

3. Regular two-allele and three-allele phenotype systems. I.

Authors: C W COTTERMAN
Journal: Am J Hum Genet Date: 1953-09 Impact factor: 11.025

4. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors: J Ott
Journal: Am J Hum Genet Date: 1974-09 Impact factor: 11.025

5. A general model for the genetic analysis of pedigree data.

Authors: R C Elston; J Stewart
Journal: Hum Hered Date: 1971 Impact factor: 0.444

6. Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.

Authors: J M Murray; K E Davies; P S Harper; L Meredith; C R Mueller; R Williamson
Journal: Nature Date: 1982-11-04 Impact factor: 49.962

7. Resolution of linkage for irregular phenotype systems.

Authors: N E Morton; J M Lalouel
Journal: Hum Hered Date: 1981 Impact factor: 0.444

Review 8. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Authors: D Botstein; R L White; M Skolnick; R W Davis
Journal: Am J Hum Genet Date: 1980-05 Impact factor: 11.025

8 in total

546 in total

1. Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops.

Authors: C S Jensen; A Kong
Journal: Am J Hum Genet Date: 1999-09 Impact factor: 11.025

2. Diaphragmatic spinal muscular atrophy with respiratory distress is heterogeneous, and one form Is linked to chromosome 11q13-q21.

Authors: K Grohmann; T F Wienker; K Saar; S Rudnik-Schöneborn; G Stoltenburg-Didinger; R Rossi; G Novelli; G Nürnberg; A Pfeufer; B Wirth; A Reis; K Zerres; C Hübner
Journal: Am J Hum Genet Date: 1999-11 Impact factor: 11.025

3. Assessment of parent-of-origin effects in linkage analysis of quantitative traits.

Authors: R L Hanson; S Kobes; R S Lindsay; W C Knowler
Journal: Am J Hum Genet Date: 2001-03-13 Impact factor: 11.025

4. Autosomal dominant cerebellar ataxia type III: linkage in a large British family to a 7.6-cM region on chromosome 15q14-21.3.

Authors: P F Worth; P Giunti; C Gardner-Thorpe; P H Dixon; M B Davis; N W Wood
Journal: Am J Hum Genet Date: 1999-08 Impact factor: 11.025

Easy calculations of lod scores and genetic risks on small computers.

1. Extensions to pedigree analysis I. Likehood calculations for simple and complex pedigrees.

2. Sequential tests for the detection of linkage.

3. Regular two-allele and three-allele phenotype systems. I.

4. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

5. A general model for the genetic analysis of pedigree data.

6. Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.

7. Resolution of linkage for irregular phenotype systems.

Review 8. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1. Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops.

2. Diaphragmatic spinal muscular atrophy with respiratory distress is heterogeneous, and one form Is linked to chromosome 11q13-q21.

3. Assessment of parent-of-origin effects in linkage analysis of quantitative traits.

4. Autosomal dominant cerebellar ataxia type III: linkage in a large British family to a 7.6-cM region on chromosome 15q14-21.3.

5. A locus for brachydactyly type A-1 maps to chromosome 2q35-q36.

6. A new locus for generalized epilepsy with febrile seizures plus maps to chromosome 2.

7. Computer support for genetic advice in primary care.

8. Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method.

Review 9. Gene mapping by linkage and association analysis.

10. Linkage of tuberculosis to chromosome 2q35 loci, including NRAMP1, in a large aboriginal Canadian family.