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Literature DB >> 3752084

The number of families required to detect or exclude linkage heterogeneity.

Abstract

Under the assumption of two family types, one with linkage and one without linkage, the number of phase-known double-backcross families required to detect heterogeneity is investigated. The case of testing for heterogeneity with two offspring per family is shown to be formally equivalent to testing for inbreeding effects in a sample of unrelated individuals.

Mesh：

Year: 1986 PMID： 3752084 PMCID： PMC1683933

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

2 in total

1. Detection of inbreeding effects by the chi-square test on genotypic and phenotypic frequencies.

Authors: M Haber
Journal: Am J Hum Genet Date: 1980-09 Impact factor: 11.025

2. Detecting linkage for genetically heterogeneous diseases and detecting heterogeneity with linkage data.

Authors: L L Cavalli-Sforza; M C King
Journal: Am J Hum Genet Date: 1986-05 Impact factor: 11.025

2 in total

10 in total

1. Paget disease of bone: mapping of two loci at 5q35-qter and 5q31.

Authors: N Laurin; J P Brown; A Lemainque; A Duchesne; D Huot; Y Lacourcière; G Drapeau; J Verreault; V Raymond; J Morissette
Journal: Am J Hum Genet Date: 2001-07-25 Impact factor: 11.025

2. Sampling strategies for linkage studies.

Authors: L R Goldin; M M Martinez; E S Gershon
Journal: Eur Arch Psychiatry Clin Neurosci Date: 1991 Impact factor: 5.270

3. The detection of linkage and heterogeneity in nuclear families for complex disorders: one versus two marker loci.

Authors: M M Martinez; L R Goldin
Journal: Am J Hum Genet Date: 1989-04 Impact factor: 11.025

4. Heterogeneity in the map distance between X-linked agammaglobulinemia and a map of nine RFLP loci.

Authors: J Ott; E J Mensink; A Thompson; J D Schot; R K Schuurman
Journal: Hum Genet Date: 1986-11 Impact factor: 4.132

5. A second-generation genomic screen for multiple sclerosis.

Authors: S J Kenealy; M-C Babron; Y Bradford; N Schnetz-Boutaud; J L Haines; J B Rimmler; S Schmidt; M A Pericak-Vance; L F Barcellos; R R Lincoln; J R Oksenberg; S L Hauser; M Clanet; D Brassat; G Edan; J Yaouanq; G Semana; I Cournu-Rebeix; O Lyon-Caen; B Fontaine
Journal: Am J Hum Genet Date: 2004-10-19 Impact factor: 11.025

The number of families required to detect or exclude linkage heterogeneity.

1. Detection of inbreeding effects by the chi-square test on genotypic and phenotypic frequencies.

2. Detecting linkage for genetically heterogeneous diseases and detecting heterogeneity with linkage data.

1. Paget disease of bone: mapping of two loci at 5q35-qter and 5q31.

2. Sampling strategies for linkage studies.

3. The detection of linkage and heterogeneity in nuclear families for complex disorders: one versus two marker loci.

4. Heterogeneity in the map distance between X-linked agammaglobulinemia and a map of nine RFLP loci.

5. A second-generation genomic screen for multiple sclerosis.

6. Prenatal prediction of osteogenesis imperfecta (OI type IV): exclusion of inheritance using a collagen gene probe.

7. Autosomal dominant retinitis pigmentosa: no evidence for nonallelic genetic heterogeneity on 3q.

8. Consistent linkage of dominantly inherited osteogenesis imperfecta to the type I collagen loci: COL1A1 and COL1A2.

Review 9. Genetic studies of IgA nephropathy: past, present, and future.

10. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.