Literature DB >> 2570529

Linkage heterogeneity between X-linked retinitis pigmentosa and a map of 10 RFLP loci.

J D Chen1, F Halliday, G Keith, L Sheffield, P Dickinson, R Gray, I Constable, M Denton.   

Abstract

In nine families in which X-linked retinitis pigmentosa (XLRP) is segregating, the lod scores of XLRP in a map of 10 RFLP loci were obtained by multipoint linkage analysis. The XLRP locus was located telomeric to DXS7 in seven of the families and centromeric to DXS7 in two of the families. Under the hypothesis of two XLRP loci, a heterogeneity (admixture) test was performed, providing significant evidence of heterogeneity in XLRP (P less than .01). No correlation was detected between the clinical manifestations of XLRP and the two different disease loci.

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Year:  1989        PMID： 2570529      PMCID： PMC1683416     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  20 in total

1.  TESTING FOR HETEROGENEITY OF RECOMBINATION FRACTION VALUES IN HUMAN GENETICS.

Authors:  C A SMITH
Journal:  Ann Hum Genet       Date:  1963-11       Impact factor: 1.670

2.  X-linked retinitis pigmentosa.

Authors:  A C Bird
Journal:  Br J Ophthalmol       Date:  1975-04       Impact factor: 4.638

3.  Localization of the gene for X-linked recessive type of retinitis pigmentosa (XLRP) to Xp21 by linkage analysis.

Authors:  M A Musarella; A Burghes; L Anson-Cartwright; M M Mahtani; R Argonza; L C Tsui; R Worton
Journal:  Am J Hum Genet       Date:  1988-10       Impact factor: 11.025

4.  Analysis of linkage relationships of X-linked retinitis pigmentosa with the following Xp loci: L1.28, OTC, 754, XJ-1.1, pERT87, and C7.

Authors:  M J Denton; J D Chen; S Serravalle; P Colley; F B Halliday; J Donald
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

5.  Localization of the X-linked retinitis pigmentosa locus between DXS7 and DXS84 in a family showing tapetal reflex in heterozygotes.

Authors:  J D Chen; F Halliday; S Serravalle; M Denton
Journal:  Ophthalmic Paediatr Genet       Date:  1988-11

6.  Heterogeneity in the map distance between X-linked agammaglobulinemia and a map of nine RFLP loci.

Authors:  J Ott; E J Mensink; A Thompson; J D Schot; R K Schuurman
Journal:  Hum Genet       Date:  1986-11       Impact factor: 4.132

7.  A genetic linkage map of five marker loci in and around the Duchenne muscular dystrophy locus.

Authors:  J D Chen; J F Hejtmancik; G Romeo; M Lindlof; C Boehm; C T Caskey; W Kress; K H Fischbeck; M Dreier; S Serravalle
Journal:  Genomics       Date:  1989-01       Impact factor: 5.736

8.  Congenital adrenal hypoplasia, myopathy, and glycerol kinase deficiency: molecular genetic evidence for deletions.

Authors:  U Francke; J F Harper; B T Darras; J M Cowan; E R McCabe; A Kohlschütter; W K Seltzer; F Saito; J Goto; J P Harpey
Journal:  Am J Hum Genet       Date:  1987-03       Impact factor: 11.025

9.  Xp21 DNA microdeletion in a patient with chronic granulomatous disease, retinitis pigmentosa, and McLeod phenotype.

Authors:  G de Saint-Basile; M C Bohler; A Fischer; J Cartron; J L Dufier; C Griscelli; S H Orkin
Journal:  Hum Genet       Date:  1988-09       Impact factor: 4.132

10.  Two different genes for X-linked retinitis pigmentosa.

Authors:  B Wirth; M J Denton; J D Chen; M Neugebauer; F B Halliday; M van Schooneveld; J Donald; E M Bleeker-Wagemakers; P L Pearson; A Gal
Journal:  Genomics       Date:  1988-04       Impact factor: 5.736
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  10 in total

1.  Linkage analysis of Norrie disease with X-chromosomal ornithine aminotransferase.

Authors:  J B Bateman
Journal:  Trans Am Ophthalmol Soc       Date:  1992

2.  Genetic localisation of the RP2 type of X linked retinitis pigmentosa in a large kindred.

Authors:  A F Wright; S S Bhattacharya; M A Aldred; M Jay; A D Carothers; N S Thomas; A C Bird; B Jay; H J Evans
Journal:  J Med Genet       Date:  1991-07       Impact factor: 6.318

3.  Multipoint linkage analysis and heterogeneity testing in 20 X-linked retinitis pigmentosa families.

Authors:  M A Musarella; L Anson-Cartwright; S M Leal; L D Gilbert; R G Worton; G A Fishman; J Ott
Journal:  Genomics       Date:  1990-10       Impact factor: 5.736

4.  Genetic features of retinitis pigmentosa in Turkey.

Authors:  L S Atmaca; B S Sayli; N Akarsu; K Gündüz
Journal:  Doc Ophthalmol       Date:  1995       Impact factor: 2.379

5.  Heterogeneity analysis in 40 X-linked retinitis pigmentosa families.

Authors:  P W Teague; M A Aldred; M Jay; M Dempster; C Harrison; A D Carothers; L J Hardwick; H J Evans; L Strain; D J Brock
Journal:  Am J Hum Genet       Date:  1994-07       Impact factor: 11.025

Review 6.  Ocular findings in a form of retinitis pigmentosa with a rhodopsin gene defect.

Authors:  E L Berson
Journal:  Trans Am Ophthalmol Soc       Date:  1990

7.  Juvenile glaucoma linked to GLCIA in a Panamanian family.

Authors:  P R Lichter; J E Richards; M Boehnke; M Othman; B D Cameron; H M Stringham; C A Downs; S B Lewis; B F Boyd
Journal:  Trans Am Ophthalmol Soc       Date:  1996

8.  Linkage analysis of X-linked cone-rod dystrophy: localization to Xp11.4 and definition of a locus distinct from RP2 and RP3.

Authors:  A B Seymour; A Dash-Modi; J R O'Connell; M Shaffer-Gordon; T S Mah; S T Stefko; R Nagaraja; J Brown; A E Kimura; R E Ferrell; M B Gorin
Journal:  Am J Hum Genet       Date:  1998-01       Impact factor: 11.025

9.  Localization of DNA sequences to a region within Xp11.21 between incontinentia pigmenti (IP1) X-chromosomal translocation breakpoints.

Authors:  J L Gorski; E N Burright; C E Harnden; C K Stein; T W Glover; E L Reyner
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

10.  Optic atrophy in Leber hereditary optic neuroretinopathy is probably determined by an X-chromosomal gene closely linked to DXS7.

Authors:  J Vilkki; J Ott; M L Savontaus; P Aula; E K Nikoskelainen
Journal:  Am J Hum Genet       Date:  1991-03       Impact factor: 11.025
  10 in total

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