Nitin Shivappa1,2,3, James R Hébert1,2,3,4, Valentina Rosato5,6, Marta Rossi5, Maurizio Montella7, Diego Serraino8, Carlo La Vecchia5. 1. a Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA. 2. b Department of Epidemiology and Biostatistics , Arnold School of Public Health, University of South Carolina , Columbia , South Carolina , USA. 3. c Connecting Health Innovations LLC , Columbia , South Carolina , USA. 4. d Department of Family and Preventive Medicine , University of South Carolina School of Medicine , Columbia , South Carolina , USA. 5. e Department of Clinical Sciences and Community Health , Università degli Studi di Milano , Milan , Italy. 6. f Unit of Medical Statistics , Biometry and Bioinformatics, Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy. 7. g Unit of Epidemiology , 'Fondazione G. Pascale', Istituto Nazionale dei Tumori , Naples , Italy. 8. h Unit of Cancer Epidemiology , CRO Aviano National Cancer Institute , Aviano (PN) , Italy.
Abstract
BACKGROUND: The relation between diet-related inflammation and renal cell carcinoma (RCC) has not been investigated. METHODS: In this study, we explored the association between the dietary inflammatory index (DII) and RCC in an Italian case-control study conducted between 1992 and 2004. Cases were 767 patients with incident, histologically confirmed RCC. Controls were 1534 subjects admitted to the same hospitals as cases for various acute, nonneoplastic conditions. The DII was computed based on dietary intake assessed using a reproducible and valid 78-item food frequency questionnaire. Odds ratios (ORs) were estimated through logistic regression models conditioned on age, sex, and center, and adjusted for recognized confounding factors, including total energy intake. RESULTS: Subjects in the highest quartile of DII scores (i.e., with the most proinflammatory diets) had a higher risk of RCC compared to subjects in the lowest quartile [OR 1.41, 95% confidence interval (CI) 1.02, 1.97; p-trend = 0.04)]. Apparently stronger associations were observed among females (OR 1.68, 95% CI 0.93, 3.03), subjects aged <60 yr (OR 1.77, 95% CI 1.05, 2.98), body mass index ≥25 kg/m2 (OR 1.64, 95% CI 1.07, 2.51), and ever smokers (OR 1.66, 95% CI 1.08, 2.57), in the absence of significant heterogeneity. CONCLUSION: A proinflammatory diet is associated with increased RCC risk.
BACKGROUND: The relation between diet-related inflammation and renal cell carcinoma (RCC) has not been investigated. METHODS: In this study, we explored the association between the dietary inflammatory index (DII) and RCC in an Italian case-control study conducted between 1992 and 2004. Cases were 767 patients with incident, histologically confirmed RCC. Controls were 1534 subjects admitted to the same hospitals as cases for various acute, nonneoplastic conditions. The DII was computed based on dietary intake assessed using a reproducible and valid 78-item food frequency questionnaire. Odds ratios (ORs) were estimated through logistic regression models conditioned on age, sex, and center, and adjusted for recognized confounding factors, including total energy intake. RESULTS: Subjects in the highest quartile of DII scores (i.e., with the most proinflammatory diets) had a higher risk of RCC compared to subjects in the lowest quartile [OR 1.41, 95% confidence interval (CI) 1.02, 1.97; p-trend = 0.04)]. Apparently stronger associations were observed among females (OR 1.68, 95% CI 0.93, 3.03), subjects aged <60 yr (OR 1.77, 95% CI 1.05, 2.98), body mass index ≥25 kg/m2 (OR 1.64, 95% CI 1.07, 2.51), and ever smokers (OR 1.66, 95% CI 1.08, 2.57), in the absence of significant heterogeneity. CONCLUSION: A proinflammatory diet is associated with increased RCC risk.
Authors: Ramon Estruch; Miguel Angel Martínez-González; Dolores Corella; Jordi Salas-Salvadó; Valentina Ruiz-Gutiérrez; María Isabel Covas; Miguel Fiol; Enrique Gómez-Gracia; Mari Carmen López-Sabater; Ernest Vinyoles; Fernando Arós; Manuel Conde; Carlos Lahoz; José Lapetra; Guillermo Sáez; Emilio Ros Journal: Ann Intern Med Date: 2006-07-04 Impact factor: 25.391
Authors: Nitin Shivappa; Antonella Zucchetto; Diego Serraino; Marta Rossi; Carlo La Vecchia; James R Hébert Journal: Cancer Causes Control Date: 2015-07-25 Impact factor: 2.506
Authors: Nitin Shivappa; James R Hébert; Valentina Rosato; Marta Rossi; Massimo Libra; Maurizio Montella; Diego Serraino; Carlo La Vecchia Journal: Urology Date: 2016-09-29 Impact factor: 2.649
Authors: Nitin Shivappa; Antonella Zucchetto; Maurizio Montella; Diego Serraino; Susan E Steck; Carlo La Vecchia; James R Hébert Journal: Br J Nutr Date: 2015-06-08 Impact factor: 3.718
Authors: Nitin Shivappa; Susan E Steck; Thomas G Hurley; James R Hussey; Yunsheng Ma; Ira S Ockene; Fred Tabung; James R Hébert Journal: Public Health Nutr Date: 2013-10-10 Impact factor: 4.022
Authors: Melissa Lopez-Pentecost; Tracy E Crane; David O Garcia; Lindsay N Kohler; Betsy C Wertheim; James R Hebert; Susan E Steck; Nitin Shivappa; Margarita Santiago-Torres; Marian L Neuhouser; Irene E Hatsu; Linda Snetselaar; Mridul Datta; Candyce H Kroenke; Gloria E Sarto; Cynthia A Thomson Journal: Z Gesundh Wiss Date: 2020-07-14
Authors: Catherine M Phillips; Ling-Wei Chen; Barbara Heude; Jonathan Y Bernard; Nicholas C Harvey; Liesbeth Duijts; Sara M Mensink-Bout; Kinga Polanska; Giulia Mancano; Matthew Suderman; Nitin Shivappa; James R Hébert Journal: Nutrients Date: 2019-08-12 Impact factor: 5.717