Literature DB >> 33530651

Phytochemicals in Gynecological Cancer Prevention.

Marta Woźniak1, Rafał Krajewski2, Sebastian Makuch1, Siddarth Agrawal1,2,3.   

Abstract

Gynecological cancer confers an enormous burden among women worldwide. Accumulating evidence points to the role of phytochemicals in preventing cervical, endometrial, and ovarian cancer. Experimental studies emphasize the chemopreventive and therapeutic potential of plant-derived substances by inhibiting the early stages of carcinogenesis or improving the efficacy of traditional chemotherapeutic agents. Moreover, a number of epidemiological studies have investigated associations between a plant-based diet and cancer risk. This literature review summarizes the current knowledge on the phytochemicals with proven antitumor activity, emphasizing their effectiveness and mechanism of action in gynecological cancer.

Entities:  

Keywords:  anticancer; gynecological cancers; phytochemicals

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Substances：

Year:  2021        PMID： 33530651      PMCID： PMC7865323          DOI： 10.3390/ijms22031219

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  189 in total

1.  Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling.

Authors:  Tsung-Han Lin; Wen-Hsien Hsu; Pei-Hsun Tsai; Ying-Tang Huang; Cheng-Wei Lin; Ku-Chung Chen; Inn-Ho Tsai; Chithan C Kandaswami; Chang-Jen Huang; Geen-Dong Chang; Ming-Ting Lee; Chia-Hsiung Cheng
Journal:  Food Funct       Date:  2017-04-19       Impact factor: 5.396

2.  Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study.

Authors:  Carlos A González; Noemie Travier; Leila Luján-Barroso; Xavier Castellsagué; F Xavier Bosch; Esther Roura; H Bas Bueno-de-Mesquita; Domenico Palli; Heiner Boeing; Valeria Pala; Carlotta Sacerdote; Rosario Tumino; Salvatore Panico; Jonas Manjer; Joakim Dillner; Göran Hallmans; Lennart Kjellberg; María-José Sanchez; Jone M Altzibar; Aurelio Barricarte; Carmen Navarro; Laudina Rodriguez; Naomi Allen; Timothy J Key; Rudolf Kaaks; Sabine Rohrmann; Kim Overvad; Anja Olsen; Anne Tjønneland; Christian Munk; Susanne Krüger Kjaer; Petra H M Peeters; Fränzel J B van Duijnhoven; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Antonia Trichopoulou; Vasiliki Benetou; Androniki Naska; Eiliv Lund; Dagrun Engeset; Guri Skeie; Silvia Franceschi; Nadia Slimani; Sabina Rinaldi; Elio Riboli
Journal:  Int J Cancer       Date:  2010-11-18       Impact factor: 7.396

3.  Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways.

Authors:  Elham Kashafi; Maliheh Moradzadeh; Ashraf Mohamadkhani; Saiedeh Erfanian
Journal:  Biomed Pharmacother       Date:  2017-03-01       Impact factor: 6.529

4.  Curcumin suppresses cisplatin resistance development partly via modulating extracellular vesicle-mediated transfer of MEG3 and miR-214 in ovarian cancer.

Authors:  Jing Zhang; Jinyu Liu; Xinyan Xu; Li Li
Journal:  Cancer Chemother Pharmacol       Date:  2017-02-08       Impact factor: 3.333

5.  Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells.

Authors:  Y Zhang; Y Ge; Y Chen; Q Li; J Chen; Y Dong; W Shi
Journal:  Cell Biochem Funct       Date:  2011-12-13       Impact factor: 3.685

6.  A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations.

Authors:  Giuseppe Grosso; Justyna Godos; Rosa Lamuela-Raventos; Sumantra Ray; Agnieszka Micek; Andrzej Pajak; Salvatore Sciacca; Nicolantonio D'Orazio; Daniele Del Rio; Fabio Galvano
Journal:  Mol Nutr Food Res       Date:  2017-02-07       Impact factor: 5.914

Review 7.  Endometrial Cancer: Obesity, Genetics, and Targeted Agents.

Authors:  Megan E McDonald; David P Bender
Journal:  Obstet Gynecol Clin North Am       Date:  2019-03       Impact factor: 2.844

Review 8.  Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence.

Authors:  Qiao Wang; Hongling Peng; Xiaorong Qi; Min Wu; Xia Zhao
Journal:  Signal Transduct Target Ther       Date:  2020-07-29

Review 9.  Cancer chemoprevention: a rapidly evolving field.

Authors:  W P Steward; K Brown
Journal:  Br J Cancer       Date:  2013-06-04       Impact factor: 7.640
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  3 in total

Review 1.  Role of NRF2 in Ovarian Cancer.

Authors:  Giovanni Tossetta; Sonia Fantone; Eva Montanari; Daniela Marzioni; Gaia Goteri
Journal:  Antioxidants (Basel)       Date:  2022-03-30

Review 2.  Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways.

Authors:  Zi-Wei Zhou; Hui-Zhi Long; Shuo-Guo Xu; Feng-Jiao Li; Yan Cheng; Hong-Yu Luo; Li-Chen Gao
Journal:  Front Pharmacol       Date:  2022-05-13       Impact factor: 5.988

Review 3.  Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention.

Authors:  Alejandra Rocío Pérez-Martín; Denisse Castro-Eguiluz; Lucely Cetina-Pérez; Yadira Velasco-Torres; Antonio Bahena-González; Edgar Montes-Servín; Ernesto González-Ibarra; Raquel Espinosa-Romero; Dolores Gallardo-Rincón
Journal:  Bosn J Basic Med Sci       Date:  2022-07-29       Impact factor: 3.759
  3 in total

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