Nitin Shivappa1,2, Antonella Zucchetto3,4, Diego Serraino3, Marta Rossi4, Carlo La Vecchia4, James R Hébert5,6. 1. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, 29208, USA. shivappa@email.sc.edu. 2. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA. shivappa@email.sc.edu. 3. SOC di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, PN, Italy. 4. Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. 5. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, 29208, USA. 6. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA.
Abstract
PURPOSE: Diet and inflammation have been suggested to be important risk factors for esophageal squamous cell cancer (ESCC). In this study, we examined the association between the dietary inflammatory index (DII) and ESCC in a case-control study conducted between 1992 and 1997 in Italy. METHODS: This study included 304 ESCC cases and 743 controls hospitalized for acute non-neoplastic diseases. The DII was computed based on dietary intake assessed by a reproducible and valid 78-item food frequency questionnaire. Logistic regression models were used to estimate odds ratios (ORs) conditioned on age, sex, year of interview, and area of residence and adjusted for education, smoking, alcohol drinking, BMI, physical activity, and aspirin use. Energy adjustment was performed using the residual method. RESULTS: Subjects with higher DII scores (i.e., with a more pro-inflammatory diet) had a higher risk of ESCC, with the DII being used as both a continuous variable (ORcontinuous 1.39, 95 % confidence interval, CI, 1.25-1.54; one-unit increase corresponding to ≈12 % of its range in the current study) and a categorical variable (ORquintile5vs1 2.46, 95 % CI 1.40-4.36; p trend < 0.001). CONCLUSION: These results indicate that a pro-inflammatory diet is associated with a higher risk of ESCC, even after controlling for alcohol and tobacco exposure.
PURPOSE: Diet and inflammation have been suggested to be important risk factors for esophageal squamous cell cancer (ESCC). In this study, we examined the association between the dietary inflammatory index (DII) and ESCC in a case-control study conducted between 1992 and 1997 in Italy. METHODS: This study included 304 ESCC cases and 743 controls hospitalized for acute non-neoplastic diseases. The DII was computed based on dietary intake assessed by a reproducible and valid 78-item food frequency questionnaire. Logistic regression models were used to estimate odds ratios (ORs) conditioned on age, sex, year of interview, and area of residence and adjusted for education, smoking, alcohol drinking, BMI, physical activity, and aspirin use. Energy adjustment was performed using the residual method. RESULTS: Subjects with higher DII scores (i.e., with a more pro-inflammatory diet) had a higher risk of ESCC, with the DII being used as both a continuous variable (ORcontinuous 1.39, 95 % confidence interval, CI, 1.25-1.54; one-unit increase corresponding to ≈12 % of its range in the current study) and a categorical variable (ORquintile5vs1 2.46, 95 % CI 1.40-4.36; p trend < 0.001). CONCLUSION: These results indicate that a pro-inflammatory diet is associated with a higher risk of ESCC, even after controlling for alcohol and tobacco exposure.
Authors: Daria M McMahon; James B Burch; James R Hébert; James W Hardin; Jiajia Zhang; Michael D Wirth; Shawn D Youngstedt; Nitin Shivappa; Steven J Jacobsen; Bette Caan; Stephen K Van Den Eeden Journal: Ann Epidemiol Date: 2018-11-02 Impact factor: 3.797
Authors: Nitin Shivappa; James R Hébert; Valentina Rosato; Marta Rossi; Maurizio Montella; Diego Serraino; Carlo La Vecchia Journal: Nutr Cancer Date: 2017-07-18 Impact factor: 2.900
Authors: Samuel O Antwi; Ann L Oberg; Nitin Shivappa; William R Bamlet; Kari G Chaffee; Susan E Steck; James R Hébert; Gloria M Petersen Journal: Carcinogenesis Date: 2016-02-12 Impact factor: 4.944
Authors: Amelie G Ramirez; Dorothy Long Parma; Edgar Muñoz; Kristin D Mendoza; Crystel Harb; Alan E C Holden; Michael Wargovich Journal: Contemp Clin Trials Date: 2017-03-22 Impact factor: 2.226
Authors: M D Wirth; N Shivappa; L Davis; T G Hurley; A Ortaglia; R Drayton; S N Blair; J R Hébert Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Nitin Shivappa; James R Hébert; Valentina Rosato; Marta Rossi; Massimo Libra; Maurizio Montella; Diego Serraino; Carlo La Vecchia Journal: Urology Date: 2016-09-29 Impact factor: 2.649
Authors: Nitin Shivappa; James R Hébert; Antonella Zucchetto; Maurizio Montella; Massimo Libra; Werner Garavello; Marta Rossi; Carlo La Vecchia; Diego Serraino Journal: Nutr Cancer Date: 2016-08-26 Impact factor: 2.900