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Literature DB >> 28399407

Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.

Deobrat Dixit¹, Qi Xie¹, Jeremy N Rich², Jing Crystal Zhao³.

Abstract

Messenger RNA (mRNA) modification provides an additional layer of gene regulation in cells. In this issue of Cancer Cell, Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N6-methyladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
RNA, Messenger

Year: 2017 PMID： 28399407 PMCID： PMC6482444 DOI： 10.1016/j.ccell.2017.03.010

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

10 in total

1. FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells.

Authors: Ai-Hua Gong; Ping Wei; Sicong Zhang; Jun Yao; Ying Yuan; Ai-Dong Zhou; Frederick F Lang; Amy B Heimberger; Ganesh Rao; Suyun Huang
Journal: Cancer Res Date: 2015-04-01 Impact factor: 12.701

2. Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.

Authors: Shay Geula; Sharon Moshitch-Moshkovitz; Dan Dominissini; Abed AlFatah Mansour; Nitzan Kol; Mali Salmon-Divon; Vera Hershkovitz; Eyal Peer; Nofar Mor; Yair S Manor; Moshe Shay Ben-Haim; Eran Eyal; Sharon Yunger; Yishay Pinto; Diego Adhemar Jaitin; Sergey Viukov; Yoach Rais; Vladislav Krupalnik; Elad Chomsky; Mirie Zerbib; Itay Maza; Yoav Rechavi; Rada Massarwa; Suhair Hanna; Ido Amit; Erez Y Levanon; Ninette Amariglio; Noam Stern-Ginossar; Noa Novershtern; Gideon Rechavi; Jacob H Hanna
Journal: Science Date: 2015-01-01 Impact factor: 47.728

3. Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.

Authors: David L Schonberg; Tyler E Miller; Qiulian Wu; William A Flavahan; Nupur K Das; James S Hale; Christopher G Hubert; Stephen C Mack; Awad M Jarrar; Robert T Karl; Ann Mari Rosager; Anne M Nixon; Paul J Tesar; Petra Hamerlik; Bjarne W Kristensen; Craig Horbinski; James R Connor; Paul L Fox; Justin D Lathia; Jeremy N Rich
Journal: Cancer Cell Date: 2015-10-12 Impact factor: 31.743

4. Reversible methylation of m⁶A_m in the 5' cap controls mRNA stability.

Authors: Jan Mauer; Xiaobing Luo; Alexandre Blanjoie; Xinfu Jiao; Anya V Grozhik; Deepak P Patil; Bastian Linder; Brian F Pickering; Jean-Jacques Vasseur; Qiuying Chen; Steven S Gross; Olivier Elemento; Françoise Debart; Megerditch Kiledjian; Samie R Jaffrey
Journal: Nature Date: 2016-12-21 Impact factor: 49.962

Review 5. Update: Mechanisms Underlying N⁶-Methyladenosine Modification of Eukaryotic mRNA.

Authors: Yang Wang; Jing Crystal Zhao
Journal: Trends Genet Date: 2016-10-25 Impact factor: 11.639

6. Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.

Authors: Wen Xiao; Samir Adhikari; Ujwal Dahal; Yu-Sheng Chen; Ya-Juan Hao; Bao-Fa Sun; Hui-Ying Sun; Ang Li; Xiao-Li Ping; Wei-Yi Lai; Xing Wang; Hai-Li Ma; Chun-Min Huang; Ying Yang; Niu Huang; Gui-Bin Jiang; Hai-Lin Wang; Qi Zhou; Xiu-Jie Wang; Yong-Liang Zhao; Yun-Gui Yang
Journal: Mol Cell Date: 2016-02-11 Impact factor: 17.970

7. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells.

Authors: Yang Wang; Yue Li; Julia I Toth; Matthew D Petroski; Zhaolei Zhang; Jing Crystal Zhao
Journal: Nat Cell Biol Date: 2014-01-07 Impact factor: 28.824

8. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

Authors: Guanqun Zheng; John Arne Dahl; Yamei Niu; Peter Fedorcsak; Chun-Min Huang; Charles J Li; Cathrine B Vågbø; Yue Shi; Wen-Ling Wang; Shu-Hui Song; Zhike Lu; Ralph P G Bosmans; Qing Dai; Ya-Juan Hao; Xin Yang; Wen-Ming Zhao; Wei-Min Tong; Xiu-Jie Wang; Florian Bogdan; Kari Furu; Ye Fu; Guifang Jia; Xu Zhao; Jun Liu; Hans E Krokan; Arne Klungland; Yun-Gui Yang; Chuan He
Journal: Mol Cell Date: 2012-11-21 Impact factor: 17.970

9. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.

Authors: Chuanzhao Zhang; Debangshu Samanta; Haiquan Lu; John W Bullen; Huimin Zhang; Ivan Chen; Xiaoshun He; Gregg L Semenza
Journal: Proc Natl Acad Sci U S A Date: 2016-03-21 Impact factor: 11.205

10. m⁶A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.

Authors: Sicong Zhang; Boxuan Simen Zhao; Aidong Zhou; Kangyu Lin; Shaoping Zheng; Zhike Lu; Yaohui Chen; Erik P Sulman; Keping Xie; Oliver Bögler; Sadhan Majumder; Chuan He; Suyun Huang
Journal: Cancer Cell Date: 2017-03-23 Impact factor: 31.743

10 in total

19 in total

1. Multivalent m⁶A motifs promote phase separation of YTHDF proteins.

Authors: Yifei Gao; Gaofeng Pei; Dongxue Li; Ru Li; Yanqiu Shao; Qiangfeng Cliff Zhang; Pilong Li
Journal: Cell Res Date: 2019-08-06 Impact factor: 25.617

Review 2. Understanding m⁶A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins.

Authors: Y L Zhao; Y H Liu; R F Wu; Z Bi; Y X Yao; Q Liu; Y Z Wang; X X Wang
Journal: Mol Biotechnol Date: 2019-05 Impact factor: 2.695

Review 3. Functions of RNA N6-methyladenosine modification in cancer progression.

Authors: Bing Chen; Ya Li; Ruifeng Song; Chen Xue; Feng Xu
Journal: Mol Biol Rep Date: 2019-02-20 Impact factor: 2.316

Review 4. Functions of RNA N6-methyladenosine modification in cancer progression.

Authors: Bing Chen; Ya Li; Ruifeng Song; Chen Xue; Feng Xu
Journal: Mol Biol Rep Date: 2019-03-25 Impact factor: 2.316

5. Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA.

Authors: Hui Xian Poh; Aashiq H Mirza; Brian F Pickering; Samie R Jaffrey
Journal: PLoS Biol Date: 2022-07-19 Impact factor: 9.593

Review 6. Systematic Review of Epigenetic Therapies for Treatment of IDH-mutant Glioma.

Authors: Vaidya Govindarajan; Ashish H Shah; Long Di; Sarah Rivas; Robert K Suter; Daniel G Eichberg; Evan Luther; Victor Lu; Alexis A Morell; Michael E Ivan; Ricardo J Komotar; Nagi Ayad; Macarena De La Fuente
Journal: World Neurosurg Date: 2022-03-18 Impact factor: 2.210

10. Large-scale transcriptome analysis identified RNA methylation regulators as novel prognostic signatures for lung adenocarcinoma.

Authors: Lei Sun; Wen-Ke Liu; Xiao-Wei Du; Xiang-Li Liu; Gao Li; Yao Yao; Tao Han; Wen-Ya Li; Jia Gu
Journal: Ann Transl Med Date: 2020-06

Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.

1. FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells.

2. Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.

3. Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.

4. Reversible methylation of m⁶A_m in the 5' cap controls mRNA stability.

Review 5. Update: Mechanisms Underlying N⁶-Methyladenosine Modification of Eukaryotic mRNA.

6. Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.

7. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells.

8. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

9. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.

10. m⁶A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.

1. Multivalent m⁶A motifs promote phase separation of YTHDF proteins.

Review 2. Understanding m⁶A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins.

Review 3. Functions of RNA N6-methyladenosine modification in cancer progression.

Review 4. Functions of RNA N6-methyladenosine modification in cancer progression.

5. Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA.

Review 6. Systematic Review of Epigenetic Therapies for Treatment of IDH-mutant Glioma.

Review 7. Reading m⁶A in the Transcriptome: m⁶A-Binding Proteins.

Review 8. The role of mRNA in the development, diagnosis, treatment and prognosis of neural tumors.

Review 9. New insights into long noncoding RNAs and their roles in glioma.

10. Large-scale transcriptome analysis identified RNA methylation regulators as novel prognostic signatures for lung adenocarcinoma.

Review 5. Update: Mechanisms Underlying N6-Methyladenosine Modification of Eukaryotic mRNA.

Review 2. Understanding m6A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins.

Review 3. Functions of RNA N6-methyladenosine modification in cancer progression.

Review 4. Functions of RNA N6-methyladenosine modification in cancer progression.

Review 6. Systematic Review of Epigenetic Therapies for Treatment of IDH-mutant Glioma.

Review 7. Reading m6A in the Transcriptome: m6A-Binding Proteins.

Review 8. The role of mRNA in the development, diagnosis, treatment and prognosis of neural tumors.

Review 9. New insights into long noncoding RNAs and their roles in glioma.

Review 5. Update: Mechanisms Underlying N⁶-Methyladenosine Modification of Eukaryotic mRNA.

Review 2. Understanding m⁶A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins.

Review 7. Reading m⁶A in the Transcriptome: m⁶A-Binding Proteins.