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Literature DB >> 30911972

Functions of RNA N6-methyladenosine modification in cancer progression.

Bing Chen¹, Ya Li¹, Ruifeng Song¹, Chen Xue², Feng Xu³.

Abstract

N6-methyladenosine (m6A) serves as a major RNA methylation modification and impacts the initiation and progression of various human cancers through diverse mechanisms. It has been reported that m6A RNA methylation is involved in different physiological and pathological processes, including stem cell differentiation and motility, immune response, cellular stress, tissue renewal and viral infection. In this review, the m6A modification and its regulatory functions in a few major cancers is introduced. The detection approaches for the m6A sites identification are discussed. Additionally, the potential of the RNA m6A modification in clinical application is discussed.

Entities: Chemical Disease Gene Species

Keywords: Cancer progression; Clinical application; Detection approaches; Physiological and pathological processes; RNA N6-methyladenosine modification

Mesh：

Substances：

Year: 2019 PMID： 30911972 DOI： 10.1007/s11033-019-04655-4

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

108 in total

1. The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus.

Authors: R P Perry; D E Kelley; K Friderici; F Rottman
Journal: Cell Date: 1975-04 Impact factor: 41.582

2. Localization of N6-methyladenosine in the Rous sarcoma virus genome.

Authors: K Beemon; J Keith
Journal: J Mol Biol Date: 1977-06-15 Impact factor: 5.469

3. The YTH domain is a novel RNA binding domain.

Authors: Zhaiyi Zhang; Dominik Theler; Katarzyna H Kaminska; Michael Hiller; Pierre de la Grange; Rainer Pudimat; Ilona Rafalska; Bettina Heinrich; Janusz M Bujnicki; Frédéric H-T Allain; Stefan Stamm
Journal: J Biol Chem Date: 2010-02-18 Impact factor: 5.157

Review 4. Leukaemogenesis: more than mutant genes.

Authors: Jianjun Chen; Olatoyosi Odenike; Janet D Rowley
Journal: Nat Rev Cancer Date: 2010-01 Impact factor: 60.716

5. Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor.

Authors: Baoen Chen; Fei Ye; Lu Yu; Guifang Jia; Xiaotian Huang; Xueju Zhang; Shuying Peng; Kai Chen; Meining Wang; Shouze Gong; Ruihan Zhang; Jinya Yin; Haiyan Li; Yiming Yang; Hong Liu; Jiwen Zhang; Haiyan Zhang; Ao Zhang; Hualiang Jiang; Cheng Luo; Cai-Guang Yang
Journal: J Am Chem Soc Date: 2012-10-17 Impact factor: 15.419

Review 6. Spliceosomal snRNA modifications and their function.

Authors: John Karijolich; Yi-Tao Yu
Journal: RNA Biol Date: 2010-03-14 Impact factor: 4.652

7. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

Authors: Kate D Meyer; Yogesh Saletore; Paul Zumbo; Olivier Elemento; Christopher E Mason; Samie R Jaffrey
Journal: Cell Date: 2012-05-17 Impact factor: 41.582

8. Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA.

Authors: J M Adams; S Cory
Journal: Nature Date: 1975-05-01 Impact factor: 49.962

9. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

Authors: Guifang Jia; Ye Fu; Xu Zhao; Qing Dai; Guanqun Zheng; Ying Yang; Chengqi Yi; Tomas Lindahl; Tao Pan; Yun-Gui Yang; Chuan He
Journal: Nat Chem Biol Date: 2011-10-16 Impact factor: 15.040

10. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

Authors: Dan Dominissini; Sharon Moshitch-Moshkovitz; Schraga Schwartz; Mali Salmon-Divon; Lior Ungar; Sivan Osenberg; Karen Cesarkas; Jasmine Jacob-Hirsch; Ninette Amariglio; Martin Kupiec; Rotem Sorek; Gideon Rechavi
Journal: Nature Date: 2012-04-29 Impact factor: 49.962

16 in total

1. Gene signature and prognostic merit of M6a regulators in colorectal cancer.

Authors: Jinfeng Zhang; Xuedi Cheng; Junzheng Wang; Yongjie Huang; Junhui Yuan; Dawen Guo
Journal: Exp Biol Med (Maywood) Date: 2020-06-30

2. The m⁶A eraser FTO facilitates proliferation and migration of human cervical cancer cells.

Authors: Dongling Zou; Lei Dong; Chenying Li; Zhe Yin; Shuan Rao; Qi Zhou
Journal: Cancer Cell Int Date: 2019-12-02 Impact factor: 5.722

3. Transient Focal Ischemia Significantly Alters the m⁶A Epitranscriptomic Tagging of RNAs in the Brain.

Authors: Anil K Chokkalla; Suresh L Mehta; TaeHee Kim; Bharath Chelluboina; Jooyong Kim; Raghu Vemuganti
Journal: Stroke Date: 2019-08-22 Impact factor: 7.914

4. YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis.

Authors: Zhen Hua; Rongfang Wei; Mengjie Guo; Zigen Lin; Xichao Yu; Xinying Li; Chunyan Gu; Ye Yang
Journal: Oncogene Date: 2022-01-24 Impact factor: 8.756

5. m⁶A RNA Methylation Regulators Contribute to Malignant Progression and Have Clinical Prognostic Impact in Gastric Cancer.

Authors: Yunshu Su; Jinqi Huang; Jichang Hu
Journal: Front Oncol Date: 2019-10-18 Impact factor: 6.244

6. FTO (Fat-Mass and Obesity-Associated Protein) Participates in Hemorrhage-Induced Thalamic Pain by Stabilizing Toll-Like Receptor 4 Expression in Thalamic Neurons.

Authors: Ganglan Fu; Shibin Du; Tianfeng Huang; Minghui Cao; Xiaozhou Feng; Shaogen Wu; Sfian Albik; Alex Bekker; Yuan-Xiang Tao
Journal: Stroke Date: 2021-06-09 Impact factor: 10.170

Functions of RNA N6-methyladenosine modification in cancer progression.

1. The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus.

2. Localization of N6-methyladenosine in the Rous sarcoma virus genome.

3. The YTH domain is a novel RNA binding domain.

Review 4. Leukaemogenesis: more than mutant genes.

5. Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor.

Review 6. Spliceosomal snRNA modifications and their function.

7. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

8. Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA.

9. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

10. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

1. Gene signature and prognostic merit of M6a regulators in colorectal cancer.

2. The m⁶A eraser FTO facilitates proliferation and migration of human cervical cancer cells.

3. Transient Focal Ischemia Significantly Alters the m⁶A Epitranscriptomic Tagging of RNAs in the Brain.

4. YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis.

5. m⁶A RNA Methylation Regulators Contribute to Malignant Progression and Have Clinical Prognostic Impact in Gastric Cancer.

6. FTO (Fat-Mass and Obesity-Associated Protein) Participates in Hemorrhage-Induced Thalamic Pain by Stabilizing Toll-Like Receptor 4 Expression in Thalamic Neurons.

7. Prognostic Value of an m6A RNA Methylation Regulator-Based Signature in Patients with Hepatocellular Carcinoma.

8. A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.

Review 9. N⁶-Methyladenosine: A Potential Breakthrough for Human Cancer.

10. The m⁶A eraser FTO facilitates proliferation and migration of human cervical cancer cells.

Review 4. Leukaemogenesis: more than mutant genes.

Review 6. Spliceosomal snRNA modifications and their function.

Review 9. N6-Methyladenosine: A Potential Breakthrough for Human Cancer.

Review 9. N⁶-Methyladenosine: A Potential Breakthrough for Human Cancer.