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Literature DB >> 30637606

Understanding m⁶A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins.

Y L Zhao¹, Y H Liu¹, R F Wu¹, Z Bi¹, Y X Yao¹, Q Liu¹, Y Z Wang¹, X X Wang².

Abstract

N6-methyladenosine (m6A) is the most abundant-internal modification of eukaryotic mRNA. m6A can be installed and removed by specific enzymes. The "writer," "eraser," and "reader" of m6A modification have been reported. These discoveries facilitate our understanding of the functional significance of m6A. m6A plays an essential role in diverse biological processes by recruiting the corresponding YTH domain-containing proteins, as well as recruiting additional translation initiation factors. Here, we provide an update on the various aspects of YTH domain-containing proteins, including an introduction to the YTH domain, the categories, distribution in cells, and biological roles of YTH proteins. Then we focus on the mechanisms that YTH proteins recognize m6A and mediate the fate of methylated-RNAs in eukaryotic cells.

Entities: Chemical

Keywords: Epigenetics; RNA modifications; YTH domain; m6A; m6A binding proteins

Mesh：

Substances：

Year: 2019 PMID： 30637606 DOI： 10.1007/s12033-018-00149-z

Source DB: PubMed Journal: Mol Biotechnol ISSN： 1073-6085 Impact factor: 2.695

101 in total

1. The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn).

Authors: A M Hartmann; O Nayler; F W Schwaiger; A Obermeier; S Stamm
Journal: Mol Biol Cell Date: 1999-11 Impact factor: 4.138

2. Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures.

Authors: R M Krug; M A Morgan; A J Shatkin
Journal: J Virol Date: 1976-10 Impact factor: 5.103

3. Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus.

Authors: Ruth A Akhtar; Akhilesh B Reddy; Elizabeth S Maywood; Jonathan D Clayton; Verdun M King; Andrew G Smith; Timothy W Gant; Michael H Hastings; Charalambos P Kyriacou
Journal: Curr Biol Date: 2002-04-02 Impact factor: 10.834

4. Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA.

Authors: C M Wei; B Moss
Journal: Proc Natl Acad Sci U S A Date: 1975-01 Impact factor: 11.205

5. Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia.

Authors: TuDung T Nguyen; Lisa N Ma; Marilyn L Slovak; Charles D Bangs; Athena M Cherry; Daniel A Arber
Journal: Genes Chromosomes Cancer Date: 2006-10 Impact factor: 5.006

6. Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA.

Authors: J M Adams; S Cory
Journal: Nature Date: 1975-05-01 Impact factor: 49.962

Review 7. YTH: a new domain in nuclear proteins.

Authors: Peter Stoilov; Ilona Rafalska; Stefan Stamm
Journal: Trends Biochem Sci Date: 2002-10 Impact factor: 13.807

8. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

Authors: Timothy M Frayling; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Rachel M Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy
Journal: Science Date: 2007-04-12 Impact factor: 47.728

9. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

Authors: Angelo Scuteri; Serena Sanna; Wei-Min Chen; Manuela Uda; Giuseppe Albai; James Strait; Samer Najjar; Ramaiah Nagaraja; Marco Orrú; Gianluca Usala; Mariano Dei; Sandra Lai; Andrea Maschio; Fabio Busonero; Antonella Mulas; Georg B Ehret; Ashley A Fink; Alan B Weder; Richard S Cooper; Pilar Galan; Aravinda Chakravarti; David Schlessinger; Antonio Cao; Edward Lakatta; Gonçalo R Abecasis
Journal: PLoS Genet Date: 2007-07 Impact factor: 5.917

10. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Authors: Thomas Gerken; Christophe A Girard; Yi-Chun Loraine Tung; Celia J Webby; Vladimir Saudek; Kirsty S Hewitson; Giles S H Yeo; Michael A McDonough; Sharon Cunliffe; Luke A McNeill; Juris Galvanovskis; Patrik Rorsman; Peter Robins; Xavier Prieur; Anthony P Coll; Marcella Ma; Zorica Jovanovic; I Sadaf Farooqi; Barbara Sedgwick; Inês Barroso; Tomas Lindahl; Chris P Ponting; Frances M Ashcroft; Stephen O'Rahilly; Christopher J Schofield
Journal: Science Date: 2007-11-08 Impact factor: 47.728

10 in total

1. The structure of the Thermococcus gammatolerans McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs.

Authors: Christopher J Hosford; Anthony Q Bui; Joshua S Chappie
Journal: J Biol Chem Date: 2019-12-10 Impact factor: 5.157

Review 2. Role of m6A in osteoporosis, arthritis and osteosarcoma (Review).

Authors: Yibo Hu; Xiaohui Zhao
Journal: Exp Ther Med Date: 2021-06-30 Impact factor: 2.447

Review 3. Insights into the Regulatory Role of m⁶A Epitranscriptome in Glioblastoma.

Authors: Silvia Galardi; Alessandro Michienzi; Silvia Anna Ciafrè
Journal: Int J Mol Sci Date: 2020-04-17 Impact factor: 5.923

4. RNAmetasome network for macromolecule biogenesis in human cells.

Authors: Shiro Iuchi; Joao A Paulo
Journal: Commun Biol Date: 2021-12-15

5. YTH Domain Proteins Play an Essential Role in Rice Growth and Stress Response.

Authors: Weiwei Ma; Song Cui; Zhenfei Lu; Xiaofeng Yan; Long Cai; Yongfa Lu; Kefeng Cai; Huacheng Zhou; Rongrong Ma; Shirong Zhou; Xiaole Wang
Journal: Plants (Basel) Date: 2022-08-25

Review 6. Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology.

Authors: Xiao Yang; Ming Liu; Mengmeng Li; Sen Zhang; Hong Hiju; Jing Sun; Zhihai Mao; Minhua Zheng; Bo Feng
Journal: Mol Cancer Date: 2020-03-24 Impact factor: 27.401

7. Modified base-binding EVE and DCD domains: striking diversity of genomic contexts in prokaryotes and predicted involvement in a variety of cellular processes.

Authors: Ryan T Bell; Yuri I Wolf; Eugene V Koonin
Journal: BMC Biol Date: 2020-11-04 Impact factor: 7.431

Understanding m⁶A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins.

1. The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn).

2. Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures.

3. Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus.

4. Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA.

5. Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia.

6. Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA.

Review 7. YTH: a new domain in nuclear proteins.

8. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

9. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

10. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

1. The structure of the Thermococcus gammatolerans McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs.

Review 2. Role of m6A in osteoporosis, arthritis and osteosarcoma (Review).

Review 3. Insights into the Regulatory Role of m⁶A Epitranscriptome in Glioblastoma.

4. RNAmetasome network for macromolecule biogenesis in human cells.

5. YTH Domain Proteins Play an Essential Role in Rice Growth and Stress Response.

Review 6. Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology.

7. Modified base-binding EVE and DCD domains: striking diversity of genomic contexts in prokaryotes and predicted involvement in a variety of cellular processes.

Review 8. The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer.

Review 9. Epitranscriptomic signatures in stem cell differentiation to the neuronal lineage.

Review 10. N⁶ -methyladenosine (m⁶A) RNA modification in human cancer.

Review 7. YTH: a new domain in nuclear proteins.

Review 2. Role of m6A in osteoporosis, arthritis and osteosarcoma (Review).

Review 3. Insights into the Regulatory Role of m6A Epitranscriptome in Glioblastoma.

Review 6. Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology.

Review 8. The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer.

Review 9. Epitranscriptomic signatures in stem cell differentiation to the neuronal lineage.

Review 10. N6 -methyladenosine (m6A) RNA modification in human cancer.

Review 3. Insights into the Regulatory Role of m⁶A Epitranscriptome in Glioblastoma.

Review 10. N⁶ -methyladenosine (m⁶A) RNA modification in human cancer.