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Literature DB >> 28255179

Design and Feasibility Study of a Single Photon Emission Microscope System for Small Animal I-125 Imaging.

L J Meng¹, N H Clinthorne², S Skinner³, R V Hay⁴, M Gross³.

Abstract

This paper presents a design study of a single photon emission microscope (SPEM) system for small animal imaging using I-125 labelled radiotracers. This system is based on the use of a very-high resolution gamma camera coupled to a converging non-multiplexing multiple pinhole collimator. This enables one to "zoom" into a small local region inside the object to extract imaging information with a very high spatial resolution and a reasonable sensitivity for gamma rays emitted from this local region. The SPEM system also includes a pinhole (or multiple pinhole) gamma camera that has a full angular coverage of the entire object. The designed imaging spatial resolution for the SPEM system is between 250 μm to 500 μm FWHM.

Entities: Chemical Species

Keywords: Converging non-multiplexing multiple pinhole aperture; microscope; very-high spatial resolution gamma camera

Year: 2006 PMID： 28255179 PMCID： PMC5330363 DOI： 10.1109/TNS.2006.871405

Source DB: PubMed Journal: IEEE Trans Nucl Sci ISSN： 0018-9499 Impact factor: 1.679

15 in total

1. A theoretical study of the contrast recovery and variance of MAP reconstructions from PET data.

Authors: J Qi; R M Leahy
Journal: IEEE Trans Med Imaging Date: 1999-04 Impact factor: 10.048

2. A modified uniform Cramer-Rao bound for multiple pinhole aperture design.

Authors: L J Meng; N H Clinthorne
Journal: IEEE Trans Med Imaging Date: 2004-07 Impact factor: 10.048

3. Design and simulation of a high-resolution stationary SPECT system for small animals.

Authors: Freek J Beekman; Brendan Vastenhouw
Journal: Phys Med Biol Date: 2004-10-07 Impact factor: 3.609

4. Photon-counting versus an integrating CCD-based gamma camera: important consequences for spatial resolution.

Authors: Freek J Beekman; Gerralt A de Vree
Journal: Phys Med Biol Date: 2005-05-25 Impact factor: 3.609

5. Mean and variance of implicitly defined biased estimators (such as penalized maximum likelihood): applications to tomography.

Authors: J A Fessler
Journal: IEEE Trans Image Process Date: 1996 Impact factor: 10.856

3. Evaluation of image reconstruction for mouse brain imaging with synthetic collimation from highly multiplexed SiliSPECT projections.

Authors: S Shokouhi; D W Wilson; S D Metzler; T E Peterson
Journal: Phys Med Biol Date: 2010-08-16 Impact factor: 3.609

4. SPECT system optimization against a discrete parameter space.

Authors: L J Meng; N Li
Journal: Phys Med Biol Date: 2013-04-15 Impact factor: 3.609

4 in total

Design and Feasibility Study of a Single Photon Emission Microscope System for Small Animal I-125 Imaging.

1. A theoretical study of the contrast recovery and variance of MAP reconstructions from PET data.

2. A modified uniform Cramer-Rao bound for multiple pinhole aperture design.

3. Design and simulation of a high-resolution stationary SPECT system for small animals.

4. Photon-counting versus an integrating CCD-based gamma camera: important consequences for spatial resolution.

5. Mean and variance of implicitly defined biased estimators (such as penalized maximum likelihood): applications to tomography.

6. Conjugate-gradient preconditioning methods for shift-variant PET image reconstruction.

7. Spatial resolution and noise tradeoffs in pinhole imaging system design: a density estimation approach.

8. Aperture optimization for emission imaging: effect of a spatially varying background.

9. Radioimmunoscintigraphy of human met-expressing tumor xenografts using met3, a new monoclonal antibody.

10. Performance evaluation of a pinhole SPECT system for myocardial perfusion imaging of mice.

Review 1. The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging.

2. Multi-pinhole SPECT Imaging with Silicon Strip Detectors.

3. Evaluation of image reconstruction for mouse brain imaging with synthetic collimation from highly multiplexed SiliSPECT projections.

4. SPECT system optimization against a discrete parameter space.