Mary Kate Manhard1,2, Kevin D Harkins1,2, Daniel F Gochberg2,3,4, Jeffry S Nyman1,2,5,6,7, Mark D Does1,2,3,8. 1. Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA. 2. Vanderbilt University Institute of Imaging Science, Nashville, Tennessee, USA. 3. Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA. 4. Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA. 5. Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee, USA. 6. Orthopaedic Surgery and Rehabilitation, Vanderbilt University, Nashville, Tennessee, USA. 7. Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. 8. Electrical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Abstract
PURPOSE: MRI of cortical bone has the potential to offer new information about fracture risk. Current methods are typically performed with 3D acquisitions, which suffer from long scan times and are generally limited to extremities. This work proposes using 2D UTE with half pulses for quantitatively mapping bound and pore water in cortical bone. METHODS: Half-pulse 2D UTE methods were implemented on a 3T Philips Achieva scanner using an optimized slice-select gradient waveform, with preparation pulses to selectively image bound or pore water. The 2D methods were quantitatively compared with previously implemented 3D methods in the tibia in five volunteers. RESULTS: The mean difference between bound and pore water concentration acquired from 3D and 2D sequences was 0.6 and 0.9 mol 1 H/Lbone (3 and 12%, respectively). While 2D pore water methods tended to slightly overestimate concentrations relative to 3D methods, differences were less than scan-rescan uncertainty and expected differences between healthy and fracture-prone bones. CONCLUSION: Quantitative bound and pore water concentration mapping in cortical bone can be accelerated by 2 orders of magnitude using 2D protocols with optimized half-pulse excitation. Magn Reson Med 77:945-950, 2017.
PURPOSE: MRI of cortical bone has the potential to offer new information about fracture risk. Current methods are typically performed with 3D acquisitions, which suffer from long scan times and are generally limited to extremities. This work proposes using 2D UTE with half pulses for quantitatively mapping bound and pore water in cortical bone. METHODS: Half-pulse 2D UTE methods were implemented on a 3T Philips Achieva scanner using an optimized slice-select gradient waveform, with preparation pulses to selectively image bound or pore water. The 2D methods were quantitatively compared with previously implemented 3D methods in the tibia in five volunteers. RESULTS: The mean difference between bound and pore water concentration acquired from 3D and 2D sequences was 0.6 and 0.9 mol 1 H/Lbone (3 and 12%, respectively). While 2D pore water methods tended to slightly overestimate concentrations relative to 3D methods, differences were less than scan-rescan uncertainty and expected differences between healthy and fracture-prone bones. CONCLUSION: Quantitative bound and pore water concentration mapping in cortical bone can be accelerated by 2 orders of magnitude using 2D protocols with optimized half-pulse excitation. Magn Reson Med 77:945-950, 2017.
Authors: Won C Bae; Peter C Chen; Christine B Chung; Koichi Masuda; Darryl D'Lima; Jiang Du Journal: J Bone Miner Res Date: 2012-04 Impact factor: 6.741
Authors: Mary Kate Manhard; Sasidhar Uppuganti; Mathilde Granke; Daniel F Gochberg; Jeffry S Nyman; Mark D Does Journal: Bone Date: 2016-03-16 Impact factor: 4.398
Authors: Saeed Jerban; Yajun Ma; Liang Li; Hyungseok Jang; Lidi Wan; Tan Guo; Adam Searleman; Eric Y Chang; Jiang Du Journal: Bone Date: 2019-06-05 Impact factor: 4.398