Saeed Jerban1, Yajun Ma2, Hyungseok Jang2, Behnam Namiranian2, Nicole Le3, Hoda Shirazian2, Mark E Murphy4, Jiang Du2, Eric Y Chang5. 1. Department of Radiology, University of California, San Diego, La Jolla, CA, USA. Electronic address: sjerban@ucsd.edu. 2. Department of Radiology, University of California, San Diego, La Jolla, CA, USA. 3. Research Service, Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, CA, USA. 4. Orthopedic Surgery Service, Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, CA, USA. 5. Research Service, Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, CA, USA; Department of Radiology, University of California, San Diego, La Jolla, CA, USA. Electronic address: ericchang.2@va.gov.
Abstract
PURPOSE: To investigate the correlations between cortical bone microstructural properties and total water proton density (TWPD) obtained from three-dimensional ultrashort echo time Cones (3D-UTE-Cones) magnetic resonance imaging techniques. MATERIALS AND METHODS: 135 cortical bone samples were harvested from human tibial and femoral midshafts of 37 donors (61 ± 24 years old). Samples were scanned using 3D-UTE-Cones sequences on a clinical 3T MRI and on a high-resolution micro-computed tomography (μCT) scanner. TWPD was measured using 3D-UTE-Cones MR images. Average bone porosity, pore size, and bone mineral density (BMD) were measured from μCT images at 9 μm voxel size. Pearson's correlation coefficients between TWPD and μCT-based measures were calculated. RESULTS: TWPD showed significant moderate correlation with both average bone porosity (R = 0.66, p < 0.01) and pore size (R = 0.57, p < 0.01). TWPD also showed significant strong correction with BMD (R = 0.71, p < 0.01). CONCLUSIONS: The presented 3D-UTE-Cones imaging technique allows assessment of TWPD in human cortical bone. This quick UTE-MRI-based technique was capable of predicting bone microstructure differences with significant correlations. Such correlations highlight the potential of UTE-MRI-based measurement of bone water proton density to assess bone microstructure.
PURPOSE: To investigate the correlations between cortical bone microstructural properties and total water proton density (TWPD) obtained from three-dimensional ultrashort echo time Cones (3D-UTE-Cones) magnetic resonance imaging techniques. MATERIALS AND METHODS: 135 cortical bone samples were harvested from human tibial and femoral midshafts of 37 donors (61 ± 24 years old). Samples were scanned using 3D-UTE-Cones sequences on a clinical 3T MRI and on a high-resolution micro-computed tomography (μCT) scanner. TWPD was measured using 3D-UTE-Cones MR images. Average bone porosity, pore size, and bone mineral density (BMD) were measured from μCT images at 9 μm voxel size. Pearson's correlation coefficients between TWPD and μCT-based measures were calculated. RESULTS: TWPD showed significant moderate correlation with both average bone porosity (R = 0.66, p < 0.01) and pore size (R = 0.57, p < 0.01). TWPD also showed significant strong correction with BMD (R = 0.71, p < 0.01). CONCLUSIONS: The presented 3D-UTE-Cones imaging technique allows assessment of TWPD in human cortical bone. This quick UTE-MRI-based technique was capable of predicting bone microstructure differences with significant correlations. Such correlations highlight the potential of UTE-MRI-based measurement of bone water proton density to assess bone microstructure.
Authors: Hamidreza Saligheh Rad; Shing Chun Benny Lam; Jeremy F Magland; Henry Ong; Cheng Li; Hee Kwon Song; James Love; Felix W Wehrli Journal: NMR Biomed Date: 2011-01-28 Impact factor: 4.044
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