Literature DB >> 27865128

The pleiotropic role of non-coding genes in development and cancer.

Alessandra Pasut1, Akinobu Matsumoto1, John G Clohessy1, Pier Paolo Pandolfi2.   

Abstract

The expansive dimension of non-coding genes is by now a well-recognized feature of eukaryotes genomes. Over the past decades, in vitro functional studies and in vivo manipulation of non-coding genes through Genetically Engineered Mouse Models (GEMMs) have provided compelling evidence that almost every biological phenomenon is regulated, at some level, by non-coding RNA transcripts or by coding RNAs with non-coding functions. In this opinion article, we will discuss how recent discoveries in the field of non-coding RNAs are contributing to advance our understanding of evolution and organismal complexity and its relevance to human diseases.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27865128      PMCID： PMC6010204          DOI： 10.1016/j.ceb.2016.10.005

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  81 in total

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Journal:  Dev Biol       Date:  2007-08-25       Impact factor: 3.582

2.  Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed.

Authors:  Agnieszka Rybak-Wolf; Christin Stottmeister; Petar Glažar; Marvin Jens; Natalia Pino; Sebastian Giusti; Mor Hanan; Mikaela Behm; Osnat Bartok; Reut Ashwal-Fluss; Margareta Herzog; Luisa Schreyer; Panagiotis Papavasileiou; Andranik Ivanov; Marie Öhman; Damian Refojo; Sebastian Kadener; Nikolaus Rajewsky
Journal:  Mol Cell       Date:  2015-04-23       Impact factor: 17.970

Review 3.  Role of non-coding sequence variants in cancer.

Authors:  Ekta Khurana; Yao Fu; Dimple Chakravarty; Francesca Demichelis; Mark A Rubin; Mark Gerstein
Journal:  Nat Rev Genet       Date:  2016-01-19       Impact factor: 53.242

Review 4.  lincRNAs: genomics, evolution, and mechanisms.

Authors:  Igor Ulitsky; David P Bartel
Journal:  Cell       Date:  2013-07-03       Impact factor: 41.582

Review 5.  MicroRNA control of signal transduction.

Authors:  Masafumi Inui; Graziano Martello; Stefano Piccolo
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Review 6.  The biological functions of miRNAs: lessons from in vivo studies.

Authors:  Joana A Vidigal; Andrea Ventura
Journal:  Trends Cell Biol       Date:  2014-12-04       Impact factor: 20.808

Review 7.  The multilayered complexity of ceRNA crosstalk and competition.

Authors:  Yvonne Tay; John Rinn; Pier Paolo Pandolfi
Journal:  Nature       Date:  2014-01-16       Impact factor: 49.962

8.  Dicer is essential for mouse development.

Authors:  Emily Bernstein; Sang Yong Kim; Michelle A Carmell; Elizabeth P Murchison; Heather Alcorn; Mamie Z Li; Alea A Mills; Stephen J Elledge; Kathryn V Anderson; Gregory J Hannon
Journal:  Nat Genet       Date:  2003-10-05       Impact factor: 38.330

9.  The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.

Authors:  Thomas Derrien; Rory Johnson; Giovanni Bussotti; Andrea Tanzer; Sarah Djebali; Hagen Tilgner; Gregory Guernec; David Martin; Angelika Merkel; David G Knowles; Julien Lagarde; Lavanya Veeravalli; Xiaoan Ruan; Yijun Ruan; Timo Lassmann; Piero Carninci; James B Brown; Leonard Lipovich; Jose M Gonzalez; Mark Thomas; Carrie A Davis; Ramin Shiekhattar; Thomas R Gingeras; Tim J Hubbard; Cedric Notredame; Jennifer Harrow; Roderic Guigó
Journal:  Genome Res       Date:  2012-09       Impact factor: 9.043

10.  Genome-wide analysis of noncoding regulatory mutations in cancer.

Authors:  Nils Weinhold; Anders Jacobsen; Nikolaus Schultz; Chris Sander; William Lee
Journal:  Nat Genet       Date:  2014-09-28       Impact factor: 38.330
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  11 in total

Review 1.  The functional roles of exosomes-derived long non-coding RNA in human cancer.

Authors:  Feiyu Chen; Ning Wang; Hor-Yue Tan; Wei Guo; Cheng Zhang; Yibin Feng
Journal:  Cancer Biol Ther       Date:  2019-02-11       Impact factor: 4.742

2.  H2B monoubiquitination: t'ub or not t'ub for inducible enhancers.

Authors:  Gregory Segala; Didier Picard
Journal:  Transcription       Date:  2017-02-08

3.  Integrated analysis of dosage effect lncRNAs in lung adenocarcinoma based on comprehensive network.

Authors:  Yunzhen Wei; Zichuang Yan; Cheng Wu; Qiang Zhang; Yinling Zhu; Kun Li; Yan Xu
Journal:  Oncotarget       Date:  2017-08-03

4.  Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse.

Authors:  Sara Carmela Credendino; Nicole Lewin; Miriane de Oliveira; Swaraj Basu; Barbara D'Andrea; Elena Amendola; Luigi Di Guida; Antonio Nardone; Remo Sanges; Mario De Felice; Gabriella De Vita
Journal:  Int J Genomics       Date:  2017-09-10       Impact factor: 2.326

5.  CiRS-7 targeting miR-7 modulates the progression of non-small cell lung cancer in a manner dependent on NF-κB signalling.

Authors:  Chongyu Su; Yi Han; Hongtao Zhang; Yunsong Li; Ling Yi; Xiaojue Wang; Shijie Zhou; Daping Yu; Xiaoyun Song; Ning Xiao; Xiaoqing Cao; Zhidong Liu
Journal:  J Cell Mol Med       Date:  2018-03-13       Impact factor: 5.310

Review 6.  Mass Spectrometry-Based Proteomics to Unveil the Non-coding RNA World.

Authors:  Roberto Giambruno; Marija Mihailovich; Tiziana Bonaldi
Journal:  Front Mol Biosci       Date:  2018-11-08

Review 7.  Microbial Agents as Putative Inducers of B Cell Lymphoma in Sjögren's Syndrome through an Impaired Epigenetic Control: The State-of-The-Art.

Authors:  Rossella Talotta; Piercarlo Sarzi-Puttini; Fabiola Atzeni
Journal:  J Immunol Res       Date:  2019-01-06       Impact factor: 4.818

8.  Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers.

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Journal:  Sci Rep       Date:  2021-04-02       Impact factor: 4.379

9.  The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element.

Authors:  Oskar Marín-Béjar; Aina M Mas; Jovanna González; Dannys Martinez; Alejandro Athie; Xabier Morales; Mikel Galduroz; Ivan Raimondi; Elena Grossi; Shuling Guo; Ana Rouzaut; Igor Ulitsky; Maite Huarte
Journal:  Genome Biol       Date:  2017-10-27       Impact factor: 13.583

10.  Analysis of copy number alterations reveals the lncRNA ALAL-1 as a regulator of lung cancer immune evasion.

Authors:  Alejandro Athie; Francesco P Marchese; Jovanna González; Teresa Lozano; Ivan Raimondi; Prasanna Kumar Juvvuna; Amaya Abad; Oskar Marin-Bejar; Jacques Serizay; Dannys Martínez; Daniel Ajona; Maria Jose Pajares; Juan Sandoval; Luis M Montuenga; Chandrasekhar Kanduri; Juan J Lasarte; Maite Huarte
Journal:  J Cell Biol       Date:  2020-09-07       Impact factor: 10.539
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