| Literature DB >> 14528307 |
Emily Bernstein1, Sang Yong Kim, Michelle A Carmell, Elizabeth P Murchison, Heather Alcorn, Mamie Z Li, Alea A Mills, Stephen J Elledge, Kathryn V Anderson, Gregory J Hannon.
Abstract
To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.Entities:
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Year: 2003 PMID： 14528307 DOI： 10.1038/ng1253
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330