| Literature DB >> 24429633 |
Yvonne Tay1, John Rinn2, Pier Paolo Pandolfi1.
Abstract
Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.Entities:
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Year: 2014 PMID: 24429633 PMCID: PMC4113481 DOI: 10.1038/nature12986
Source DB: PubMed Journal: Nature ISSN: 0028-0836 Impact factor: 49.962