Literature DB >> 24429633

The multilayered complexity of ceRNA crosstalk and competition.

Yvonne Tay1, John Rinn2, Pier Paolo Pandolfi1.   

Abstract

Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.

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Year:  2014        PMID: 24429633      PMCID: PMC4113481          DOI: 10.1038/nature12986

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  100 in total

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6.  Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments.

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Journal:  Nature       Date:  2013-05-12       Impact factor: 49.962

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Review 6.  Long noncoding RNA turnover.

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9.  LncRNA Rian ameliorates sevoflurane anesthesia-induced cognitive dysfunction through regulation of miR-143-3p/LIMK1 axis.

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10.  LncRNA TATDN1 contributes to the cisplatin resistance of non-small cell lung cancer through TATDN1/miR-451/TRIM66 axis.

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