Literature DB >> 28453430

H2B monoubiquitination: t'ub or not t'ub for inducible enhancers.

Gregory Segala1, Didier Picard1.   

Abstract

Recently, we reported the unexpected finding that the monoubiquitination of histone H2B (H2Bub1) regulates inducible enhancers. Here, we propose a conceptual framework to reconcile the apparently discrepant roles of H2Bub1 in transcription initiation and elongation, and we discuss how H2Bub1 could regulate cellular processes linked to non-coding transcription.

Entities:  

Keywords:  H2B ubiquitylation; breast cancer; chromatin mark; chromatin remodeler; epigenetics; estrogen receptor; histone variant; transcription initiation

Mesh：

Substances：

Year:  2017        PMID： 28453430      PMCID： PMC5423472          DOI： 10.1080/21541264.2017.1285852

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  38 in total

1.  A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.

Authors:  Yue Zhao; Guillaume Lang; Saya Ito; Jacques Bonnet; Eric Metzger; Shun Sawatsubashi; Eriko Suzuki; Xavier Le Guezennec; Hendrik G Stunnenberg; Aleksey Krasnov; Sofia G Georgieva; Roland Schüle; Ken-Ichi Takeyama; Shigeaki Kato; László Tora; Didier Devys
Journal:  Mol Cell       Date:  2008-01-18       Impact factor: 17.970

Review 2.  Transcription-associated histone modifications and cryptic transcription.

Authors:  Michaela Smolle; Jerry L Workman
Journal:  Biochim Biophys Acta       Date:  2012-09-07

3.  The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.

Authors:  Efrat Shema; Itay Tirosh; Yael Aylon; Jing Huang; Chaoyang Ye; Neta Moskovits; Nina Raver-Shapira; Neri Minsky; Judith Pirngruber; Gabi Tarcic; Pavla Hublarova; Lilach Moyal; Mali Gana-Weisz; Yosef Shiloh; Yossef Yarden; Steven A Johnsen; Borivoj Vojtesek; Shelley L Berger; Moshe Oren
Journal:  Genes Dev       Date:  2008-10-01       Impact factor: 11.361

4.  Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

Authors:  Minna U Kaikkonen; Nathanael J Spann; Sven Heinz; Casey E Romanoski; Karmel A Allison; Joshua D Stender; Hyun B Chun; David F Tough; Rab K Prinjha; Christopher Benner; Christopher K Glass
Journal:  Mol Cell       Date:  2013-08-08       Impact factor: 17.970

Review 5.  The enigmatic role of H2Bub1 in cancer.

Authors:  Steven A Johnsen
Journal:  FEBS Lett       Date:  2012-04-13       Impact factor: 4.124

6.  The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations.

Authors:  Célia Jeronimo; Shinya Watanabe; Craig D Kaplan; Craig L Peterson; François Robert
Journal:  Mol Cell       Date:  2015-05-07       Impact factor: 17.970

7.  Site-specific DICER and DROSHA RNA products control the DNA-damage response.

Authors:  Sofia Francia; Flavia Michelini; Alka Saxena; Dave Tang; Michiel de Hoon; Viviana Anelli; Marina Mione; Piero Carninci; Fabrizio d'Adda di Fagagna
Journal:  Nature       Date:  2012-08-09       Impact factor: 49.962

8.  On the presence and role of human gene-body DNA methylation.

Authors:  Daudi Jjingo; Andrew B Conley; Soojin V Yi; Victoria V Lunyak; I King Jordan
Journal:  Oncotarget       Date:  2012-04

9.  Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription.

Authors:  Sankari Nagarajan; Tareq Hossan; Malik Alawi; Zeynab Najafova; Daniela Indenbirken; Upasana Bedi; Hanna Taipaleenmäki; Isabel Ben-Batalla; Marina Scheller; Sonja Loges; Stefan Knapp; Eric Hesse; Cheng-Ming Chiang; Adam Grundhoff; Steven A Johnsen
Journal:  Cell Rep       Date:  2014-07-10       Impact factor: 9.423

10.  INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.

Authors:  Bingying Zhou; Li Wang; Shu Zhang; Brian D Bennett; Fan He; Yan Zhang; Chengliang Xiong; Leng Han; Lixia Diao; Pishun Li; David C Fargo; Adrienne D Cox; Guang Hu
Journal:  Genes Dev       Date:  2016-06-15       Impact factor: 11.361
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  1 in total

1.  DOT1L complex regulates transcriptional initiation in human erythroleukemic cells.

Authors:  Aiwei Wu; Junhong Zhi; Tian Tian; Ali Cihan; Murat A Cevher; Ziling Liu; Yael David; Tom W Muir; Robert G Roeder; Ming Yu
Journal:  Proc Natl Acad Sci U S A       Date:  2021-07-06       Impact factor: 12.779
  1 in total

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